HUANG, WENLONG

Release date:2016-05-25  Release:

HUANG, WENLONG

Professor of Medicinal Chemistry

School of Institute of Pharmaceutical Research

Phone: 86-25-832171302

Email: ydhuangwenlong@126.com

Research Summary

Professor Huang mainly engaged in medicinal chemistry teaching and new drug molecular design, synthesis and structure-activity relationship study. His research area covers small molecular and peptide drugs in diabetes, antitumor and cardiovascular drugs. His team has successively carried out hundreds of compounds of different types of structures’ design and synthesis, biological activity and structure-activity relationship research.

Education

1985-1988  Ph.D., Medicinal Chemistry, China Pharmaceutical University

1982-1985  M.S., Medicinal Chemistry,Nanjing College of Pharmacy

1973-1977  B.S., PharmNanjing College of Pharmacy

Academic Experience

1995-presentprofessor with research projects in Cardiovascular drugs, Supervisor of Ph.D and M. S. students, lecturing postgraduates in Medicinal Chemistry, center of drug discovery, China pharmaceutical university

1992-1995assistant professor with research projects in Cardiovascular drugs, Supervisor of M. Sc. students, lecturing postgraduates in Medicinal Chemistry, center of drug discovery, China pharmaceutical university

1989-1992    Visiting scholar engaged in the investigation of dopamine and anti-malarial drugs, department of pharmacy, university of Strathclyde, U.K..

1988-1989    Lecturer with research projects in Cardiovascular drugs, Supervisor of M. Sc. students, lecturing postgraduates in Medicinal Chemistry, department of medical chemistry, China pharmaceutical university.

1977-1982pharmacist engaged in the investigation of dermatological drugs, dermatology institute of china, Jiangsu,.

Publications

  1. Lin Yan, Jingjie Wang, Miaobo Pan, Qianqian Qiu, Wenlong Huang* and Hai Qian*. Synthesis of Analogues of BCTC Incorporating a Pyrrolidinyl Linker and Biological Evaluation as Transient Receptor Potential Vanilloid 1 Antagonists. Chem Biol Drug Des. 2016, 87(2),306–311.

  2. Liu Baoming, Qiu Qianqian, Zhao Tianxiao, Jiao Lei, Li Ying, Huang Wenlong*, Qian Hai*. 6,7-Dimethoxy-2-{2-[4-(1H-1,2,3-triazol-1-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolines as superior reversal agents for P-glycoprotein-mediated multidrug resistance. ChemMedChem. 2015, 10(2), 336-344.   IF2.968

  3. Lidan Sun, Chuandong Wang, Yuxuan Dai, Yingying Chu, Jing Han, Jie Zhou, Xingguang Cai, Wenlong Huang*, Hai Qian*. Coumaglutide, a novel long-acting GLP-1 analog, inhibits β-cell apoptosis in vitro and invokes sustained glycemic control in vivo. European Journal of Pharmacology, 2015(767), 211-219.    IF2.532   

  4. Lidan Sun, Yuxuan Dai, Chuandong Wang, Yingying Chu, Xin Su, Jianyong Yang, Jie Zhou, Wenlong Huang1,* and Hai Qian1,*.  Novel Pentapeptide GLP-1 (32–36) Amide Inhibits b-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015, 86(6),  1482–1490

  5. Xin Deng, Qianqian Qiu, Ke Ma, Wenlong Huang*, Hai Qian*. Synthesis and in vitro anti-cancer evaluation of luteinizing hormone-releasing hormone-conjugated peptide. Amino Acids, 2015 (47):2359–2366.

  6. Xin Deng, Qianqian Qiu, Ke Ma, Xuekun Wang, Wenlong Huang* and Hai Qian*. Aliphatic acid-conjugated antimicrobial peptides –potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org. Biomol. Chem., 2015, 13, 7673–7680

  7. Baowei Yang†, Chenyu Zhang†, Xue Li, Sijia Yan, Wei Wei, Xuekun Wang, Xin Deng, Wenlong Huang* and Hai Qian * . Design, Synthesis, and Biological Evaluation of Novel Peptide Gly3-MC62 Analogues as Potential Antidiabetic Agents. Chem Biol Drug Des, 2015; 86(5): 979–989.

  8. Zheng Li, Xuekun Wang, Xue Xu, Jianyong Yang, Qianqian Qiu, Hao Qiang Wenlong Huang* Hai Qian*. Design, synthesis and structure–activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. Bioorganic & Medicinal Chemistry, 2015, 23( 20), 6666-6672.

  9. Zheng Li, Xuekun Wang, Xue Xu, Jianyong Yang, Wenting Xia, Xianhao Zhou, Wenlong Huang*, Hai Qian*. Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists. Bioorganic & Medicinal Chemistry, 2015, 23( 22), 7158–7164.

  10. Zheng Li, Xuekun Wang, Xue Xu, Qianqian Qiu, Lei Jiao, Wenlong Huang* and Hai Qian*. Design, Synthesis and in vivo Evaluation of Novel C-Aryl Glucosides as Potent Sodium-Dependent Glucose Cotransporters Inhibitors for the Treatment of Diabetes. Chem Biol Drug Des 2015, 86( 4 ) 764–775.

  11. Xuekun Wang, Ying Li, Baowei Yang, Zheng Li, Wenlong Huang* and Hai Qian* C-Aryl Glucosides with Substituents at the Distal Aryl Ring as Sodium-Dependent Glucose Cotransporter Inhibitors for the Treatment of Diabetes Mellitus. Chem Biol Drug Des 2015; 86(2): 246–253.

  12. Qianqian Qiu, Xin Deng, Lei Jiao, Tianxiao Zhao, Fanfei Meng, Wenlong Huang* and Hai Qian*.A High-Sensitivity Coumarin-Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells. Chem Biol Drug Des 2015; 86(1): 173–179.

  13. Jingjie Wang, Dongyan Dai, Qianqian Qiu,Xin Deng, Haiyan Lin, Hai Qian* and Wenlong Huang*, Evaluation of Anti-inflammatory and Analgesic Effects of Synthesized Derivatives of Ibuprofen. Chem Biol Drug Des, 2015,85(5): 623–632.

  14. Tianxiao Zhao, Yun Song, Baomin Liu, Qianqian Qiu, Lei Jiao,Yunman Li, Wenlong Huang,* Hai Qian*Reversal of P-glycoprotein-medicated multidrug resistance by LBM-A5 in vitro and a study of its pharmacokinetics in vivo. Canadian Journal of Physiology and Pharmacology, 2015, 93(1): 33-38.

  15. Lidan Sun, Hai Qian* and Wenlong Huang*. Virtual Screening for Cholesterol Absorption Inhibitors.  Medicinal Chemistry, 2015, 11(1), 2-12.

  16. Xin Deng, Qianqian Qiu, Baowei Yang, Xuekun Wang, Wenlong Huang* , Hai Qian*. Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities. European Journal of Medicinal Chemistry, 2015, 89(1), 540–548.

  17. Xuekun Wang, Tianxiao Zhao, Baowei Yang, Zheng Li, Jian Cui, Yuxuan Dai, Qianqian Qiu,Hao Qiang, Wenlong Huang*, Hai Qian*. Synthesis and biological evaluation of Phenoxyacetic acid Derivatives as Novel Free Fatty Acid Receptor 1 Agonists. Bioorganic & Medicinal Chemistry, 201523 (1), 132–140.

  18. Baowei Yang,‡ Xue Li,‡ Chenyu Zhang, Sijia Yan, Wei Wei, Xuekun Wang, Xin Deng, Hai Qian, Haiyan Lin* and Wenlong Huang*.  Design, synthesis and biological evaluation of novel peptide MC2 analogues from Momordica charantia as potential anti-diabetic agents. Organic & Biomolecular Chemistry, 2015, 13(15), 4551–4561.

  19. Qianqian Qiu, Jingjie Wang, Xin Deng, Hai Qian, Haiyan Lin*, and Wenlong Huang*. Synthesis of Carbamide Derivatives Bearing Tetrahydroisoquinoline Moieties and Biological Evaluation as Analgesia Drugs in Mice. Arch. Pharm. Chem. Life Sci. 2015, 348, 347–352.

  20. Lei Jiao, Qianqian Qiu, Baomin Liu, Tianxiao Zhao, Wenlong Huang*, Hai Qian*. Design, synthesis and evaluation of novel triazole core based P-glycoprotein-mediated multidrug resistance reversal agents. Bioorganic & Medicinal Chemistry , 2014, 22 (24) 6857–6866.

  21. HAN Jing, SUN Li-Dan, QIAN Hai, HUANG Wen-Long*. Biological activity studies of the novel glucagon-like peptide-1 derivative HJ07. Chinese Journal of Natural Medicines, 2014, 12 (8), 613-618

  22. Jing Han, Lidan Sun, Xun Huang, Zheng Li, Chenyu Zhang, Hai Qian* and  Wenlong Huang . Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability. British Journal of Pharmacology2014171 (23) 5252–5264.

  23. Baomin Liu, Qianqian Qiu, Tianxiao Zhao,Lei Jiao, Jianyu Hou, Yunman Li, Hai Qian*and Wenlong Huang* Discovery of Novel P-Glycoprotein-Mediated Multidrug Resistance Inhibitors Bearing Triazole Core via Click Chemistry. Chem Biol Drug Des, 2014, 84(2), 182–191.

  24. Baowei Yang1, Wukun Liu1, Yicheng Mei, Dandan Huang, Hai Qian*, Wenlong Huang* and Ronald Gust. Design, Synthesis and Biological Evaluation of 5-Amino-1H-pyrazole-4-carboxamide Derivatives as Potential Antitumor Agents. Letters in Drug Design & Discovery, 2014, 11(6),749-755.

  25. Chunlei Tang, Guolong Gu, Baowei Yang, Xuekun Wang, Hai Qian*, Wenlong Huang*, Xiaoyun Zhu and Jing Li. Synthesis and In Vivo Hepatoprotective Activity of Some Novel Andrographolide Derivatives.  Letters in Drug Design & Discovery, 2014, 11(5), 677 – 685.

  26. Chunlei Tang, Guolong Gu, Bin Wang, Xin Deng, Xiaoyun Zhu, Hai Qian* and Wenlong Huang*. Design, Synthesis, and Biological Evaluation of Andrographolide Derivatives as Potent Hepatoprotective Agents. Chem Biol Drug Des, 2014, 83(3), 324–333.

  27. Baowei Yang, Yicheng Mei, Xuekun Wang, Xin Deng, Hai Qian*, Wenlong Huang*. Design, synthesis and biological evaluation of novel peptide MC62 analogues as potential antihyperglycemic agents. European Journal of Medicinal Chemistry, 2014, (73),105-111.

  28. Jing Han, Lidan Sun, Yingying Chu, Zheng Li, Dandan Huang, Xiaoyun Zhu, Hai Qian*,  Wenlong Huang*. Design, Synthesis and Biological activity studies of Novel Dicoumarin-Glucagon-Like Peptide-1 Conjugates. Journal of Medicinal Chemistry, 201356(24), 9955-9968.

  29. Jing Han, Xun Huang, Lidan Sun, Zheng Li, Hai Qian*, Wenlong Huang*, Novel fatty chain-modified glucagon-like peptide-1 conjugates with enhanced stability and prolonged in vivo activity. Biochemical Pharmacology, 2013, 86(2) , 297-308.

  30. Andrographolide Derivatives. Letters in Drug Design & Discovery, 2013, 10(2), 155-163.

  31. Xiaobu Lan, Haiyan Lin, Chunlei Tang, Xiaoyun Zhu, Hai Qian, Wenlong Huang and Yunman Li. Evaluation of In-Vitro Multidrug Resistance Reversal Activities of HZ08 analogues with Improved Soluble Property. Letters in Drug Design & Discovery, 2013, 10(1), 56-60.

  32. Dandan Huang, Xiaoyun Zhu, Chunlei Tang, Yicheng Mei, Wei Chen, Baowei Yang, Jing Han, Hai Qian* and Wenlong Huang*. 3D QSAR Pharmacophore Modeling for c-Met Kinase Inhibitors. Medicinal Chemistry, 2012, 8(6)1117-1125.

  33. Chunlei Tang, Yajuan Liu, Bin Wang, Guolong Gu, Liumeng Yang, Yongtang Zheng, Hai Qian*, and Wenlong Huang*. Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents. Archiv der Pharmazie (Arch. Pharm. Chem. Life Sci). 2012, 345(8), 647–656.

  34. Xiaoyun Zhu, Jianfeng Ji, Dandan Huang, Yan Zhu, Chunlei Tang, Xuan Yang, Hai Qian* and Wenlong Huang*. Discovery, Synthesis and Evaluation of Novel Cholesterol Absorption Inhibitors. Chem Biol Drug Des. 2012, 80(3), 426-433.

  35. Li Jing,Zhang Huibin, Huang Wenlong,Qian Hai,Li Ying. TNF-α Inhibitors with Anti-Oxidative Stress Activity from Natural Products. Current Topics in Medicinal Chemistry, 2012, 12(13), 1408-1421.

  36. Chunlei Tang, Xiaoyun Zhu, Dandan Huang, Xin Zan and Baowei Yang, Ying Li,  Xiaoyong Du, Hai Qian*, Wenlong Huang*. A specific pharmacophore model of sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Journal of Molecular Modeling. 2012, 18(6), 2795-2804.

  37. Xin Deng, Xinxin Zhao, Jing Han, Jingjie Wang, Wenlong Huang, Hai Qian* and Liang Ge*. Synthesis and Biological Evaluation of Berberine Derivatives as IBS Modulator. Letters in Drug Design & Discovery, 2012, 9(5), 489-493.

  38. YiCheng Mei, BaoWei Yang, Wei Chen, DanDan Huang, Ying Li, Xin Deng, BaoMing Liu, JingJie Wang, Hai Qian* and WenLong Huang*. A Novel Practical Synthesis of Pazopanib: An Anticancer Drug. Letters in Organic Chemistry, 2012, 9(4), 276-279.

  39. Bin Wang#, Chunlei Tang#, Yaodan Han, Ruzhou Guo, Hai Qian* and Wenlong Huang* . Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives. Medicinal Chemistry, 2012, 8(2), 293-298.

  40. Chunlei Tang, Shu Chen, Hai Qian* and Wenlong Huang*. Interleukin-23: as a drug target for autoimmune inflammatory diseases. IMMUNOLOGY, 2012, 135(2), 112–124.

  41. Wei Chen, Yinghong Zhou, Huibin Zhang, Hai Qian*, Wenlong Huang*, Baowei Yang, Jing Han, Jingpei Zhou, Yushi Chi and Shuaijian Ni. Stability and Bioactivity Studies on Dipeptidyl Peptidase IV Resistant Glucogan-like Peptide-1 Analogues. Protein & Peptide Letters, 2012, 19(2), 203-211.

  42. Wei Chen, Baowei Yang, Huimin Zhou, Lidan Sun, Jie Dou, Hai Qian*, Wenlong Huang*, Yicheng Mei, Jing Han. Structure–activity relationships of a snake cathelicidin- related peptide, BF-15. Peptides, 2011,32 (12) ,2497–2503.

  43. Chunlei Tang, Wenjie Zhang, Xinyang Wang, Bin Wang, Xiaoyun Zhu, Dandan Huang, Xiaoyong Du, Hai Qian*, Wenlong Huang* and Jing Li. Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Antibacterial Agents.  Letters in Drug Design & Discovery, 2011, 8(9), 816-821.

  44. Yubin Wang, Hai Qian, Jinpei Zhou, Huibin Zhang, Jianfeng Ji and Wenlong Huang. Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors . Medicinal Chemistry, 2011, 7(6), 534-542

  45. JIN Jing, HUANG WenLong*, RAO GuangLing*, QIAN Hai, ZHANG HuiBin, ZHOU JinPei, WANG JingJie, CHEN Wei, DU Kuo. Total Synthesis of MC2, a Peptide from Momordica Charantia and Its Hypoglycemic Activity. Chinese Journal of Natural Medicines 2011, 9(1): 58−60.

  46. ZhiHong Zou, XiaoBu Lan, Hai Qian*, WenLong Huang*, YunMan Li. Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents.Bioorganic & Medicinal Chemistry Letters 2011 , 21 (19), 5934–5938

  47. Xiaoyun Zhu, Dandan Huang, Xiaobu Lan, Chunlei Tang, Yan Zhu, Jing Han, Wenlong Huang*, Hai Qian*. The first pharmacophore model for potent G protein-coupled receptor 119 agonist. European Journal of Medicinal Chemistry 2011,46 (7), 2901-2907

  48. Bin Wang, Jing Li, Wen Long Huang*, Hui Bin Zhang, Hai Qian*, Yong Tang Zheng. Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents . Chinese Chemical Letters 2011, 22 (7),781–784.