QIAN, HAI

Release date:2016-05-25  Release:

QIAN, HAI

Professor of Medicinal Chemistry

School of Institute of Pharmaceutical Research

Phone: 86-25-832171302

Email: qianhai24@163.com or qianhai24@cpu.edu.cn

Research Summary

Professor Qian’s research mainly focuses on small molecules and peptide drug synthesis, biological activity and structure-activity relationship study in diabetes and antitumor areas. As the principle investigator, he leads several studies. Such as the Studies on design and synthesis, hypoglycemic activity and mechanism of the analogues of the peptides from Momordica Charantia, which was sponsored by the Project of National Natural Science Foundation.

Education

2004.9 - 2007.6  Ph.D., Medicinal Chemistry, ChinaPharmaceuticalUniversity

2001.9 - 2004.6  M.S., PharmacologyGuiyang Medical University

1997.9 - 2001.6  B.S., PharmacyShandong University

Academic Experience

2015.6 - present  Professor of Medicinal Chemistry, China Pharmaceutical University

2010.5 - 2015.5Associate Professor of Medicinal Chemistry,China Pharmaceutical University

2007.7 - 2010.4  Lecturer, China Pharmaceutical University

Awards and Honors

2010SERVIER Young Investigator Awards in Medicinal Chemistry, Chinese Pharmaceutical Association

Publications

  1. Bo Zhang, Tianxiao Zhao, Jie Zhou, Qianqian Qiu, Yuxuan Dai, Mianbo Pan, Wenlong Huang* and Hai Qian*. Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance. RSC Advances, 2016, 6(31): 25819-25828.

  2. Lin Yan, Miaobo Pan, Mian Fu, Jingjie Wang, Wenlong Huang* and Hai Qian*. Design, synthesis and biological evaluation of novel analgesic agents targeting both cyclooxygenase and TRPV1. Bioorganic & Medicinal Chemistry, 2016, 24(4), 849–857.

  3. Lin Yan, Jingjie Wang, Miaobo Pan, Qianqian Qiu, Wenlong Huang* and Hai Qian*. Synthesis of Analogues of BCTC Incorporating a Pyrrolidinyl Linker and Biological Evaluation as Transient Receptor Potential Vanilloid 1 Antagonists. Chem Biol Drug Des. 2016, 87(2),  306–311.

  4. Liu Baoming, Qiu Qianqian, Zhao Tianxiao, Jiao Lei, Li Ying, Huang Wenlong*, Qian Hai*. 6,7-Dimethoxy-2-{2-[4-(1H-1,2,3-triazol-1-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolines as superior reversal agents for P-glycoprotein-mediated multidrug resistance.ChemMedChem. 2015, 10(2), 336-344.   

  5. Lidan Sun, Chuandong Wang, Yuxuan Dai, Yingying Chu, Jing Han, Jie Zhou, Xingguang Cai, Wenlong Huang*, Hai Qian*. Coumaglutide, a novel long-acting GLP-1 analog, inhibits β-cell apoptosis in vitro and invokes sustained glycemic control in vivo. European Journal of Pharmacology, 2015(767), 211-219.       

  6. Lidan Sun, Yuxuan Dai, Chuandong Wang, Yingying Chu, Xin Su, Jianyong Yang, Jie Zhou, Wenlong Huang* and Hai Qian*.  Novel Pentapeptide GLP-1 (32–36) Amide Inhibits b-Cell Apoptosis In Vitro and Improves Glucose Disposal in Streptozotocin-Induced Diabetic Mice. Chem Biol Drug Des. 2015, 86(6),  1482–1490

  7. Xin Deng, Qianqian Qiu, Ke Ma, Wenlong Huang*, Hai Qian*. Synthesis and in vitro anti-cancer evaluation of luteinizing hormone-releasing hormone-conjugated peptide. Amino Acids, 2015 (47):2359–2366.

  8. Xin Deng, Qianqian Qiu, Ke Ma, Xuekun Wang, Wenlong Huang* and Hai Qian*. Aliphatic acid-conjugated antimicrobial peptides –potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability. Org. Biomol. Chem., 2015, 13 (28), 7673–7680

  9. Baowei Yang†, Chenyu Zhang†, Xue Li, Sijia Yan, Wei Wei, Xuekun Wang, Xin Deng, Wenlong Huang* and Hai Qian * . Design, Synthesis, and Biological Evaluation of Novel Peptide Gly3-MC62 Analogues as Potential Antidiabetic Agents. Chem Biol Drug Des, 2015; 86(5): 979–989.

  10. Zheng Li, Xuekun Wang, Xue Xu, Jianyong Yang, Qianqian Qiu, Hao Qiang Wenlong Huang* Hai Qian*. Design, synthesis and structure–activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes. Bioorganic & Medicinal Chemistry, 2015, 23( 20), 6666-6672.

  11. Zheng Li, Xuekun Wang, Xue Xu, Jianyong Yang, Wenting Xia, Xianhao Zhou, Wenlong Huang*, Hai Qian*. Design, synthesis and biological activity of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists. Bioorganic & Medicinal Chemistry, 2015, 23( 22), 7158–7164.

  12. Zheng Li, Xuekun Wang, Xue Xu, Qianqian Qiu, Lei Jiao, Wenlong Huang* and Hai Qian*. Design, Synthesis and in vivo Evaluation of Novel C-Aryl Glucosides as Potent Sodium-Dependent Glucose Cotransporters Inhibitors for the Treatment of Diabetes. Chem Biol Drug Des 2015 , 86( 4 ) 764–775.

  13. Xuekun Wang, Ying Li, Baowei Yang, Zheng Li, Wenlong Huang* and Hai Qian* C-Aryl Glucosides with Substituents at the Distal Aryl Ring as Sodium-Dependent Glucose Cotransporter Inhibitors for the Treatment of Diabetes Mellitus. Chem Biol Drug Des 2015; 86(2): 246–253.

  14. Qianqian Qiu, Xin Deng, Lei Jiao, Tianxiao Zhao, Fanfei Meng, Wenlong Huang* and Hai Qian*.  A High-Sensitivity Coumarin-Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells. Chem Biol Drug Des 2015; 86(1): 173–179.

  15. Jingjie Wang, Dongyan Dai, Qianqian Qiu,Xin Deng, Haiyan Lin, Hai Qian* and Wenlong Huang*, Evaluation of Anti-inflammatory and Analgesic Effects of Synthesized Derivatives of Ibuprofen.ChemBiol Drug Des, 2015,85(5): 623–632.

  16. Tianxiao Zhao, Yun Song, Baomin Liu, Qianqian Qiu, Lei Jiao,Yunman Li, Wenlong Huang,* Hai Qian*Reversal of P-glycoprotein-medicated multidrug resistance by LBM-A5 in vitro and a study of its pharmacokinetics in vivo. Canadian Journal of Physiology and Pharmacology, 2015, 93(1): 33-38.

  17. Lidan Sun, Hai Qian* and Wenlong Huang*. Virtual Screening for Cholesterol Absorption Inhibitors. Medicinal Chemistry, 2015, 11(1), 2-12.

  18. Xin Deng, Qianqian Qiu, Baowei Yang, Xuekun Wang, Wenlong Huang* , Hai Qian*. Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities. European Journal of Medicinal Chemistry, 2015, 89(1), 540–548.

  19. Xuekun Wang, Tianxiao Zhao, Baowei Yang, Zheng Li, Jian Cui, Yuxuan Dai, Qianqian Qiu,Hao Qiang, Wenlong Huang*, Hai Qian*. Synthesis and biological evaluation of Phenoxyacetic acid Derivatives as Novel Free Fatty Acid Receptor 1 Agonists. Bioorganic & Medicinal Chemistry, 201523 (1), 132–140.

  20. Lei Jiao, Qianqian Qiu, Baomin Liu, Tianxiao Zhao, Wenlong Huang*, Hai Qian*. Design, synthesis and evaluation of novel triazole core based P-glycoprotein-mediated multidrug resistance reversal agents. Bioorganic & Medicinal Chemistry , 2014, 22 (24) 6857–6866.

  21. Jing Han†, Lidan Sun†, Xun Huang†, Zheng Li, Chenyu Zhang, Hai Qian* and  Wenlong Huang* .  Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability. British Journal of Pharmacology2014171 (23) 5252–5264.

  22. Baomin Liu, Qianqian Qiu, Tianxiao Zhao,Lei Jiao, Jianyu Hou, Yunman Li, Hai Qian*and Wenlong Huang*Discovery of Novel P-Glycoprotein-Mediated Multidrug Resistance Inhibitors Bearing Triazole Core via Click Chemistry. Chem Biol Drug Des, 2014, 84(2),  182–191.

  23. Baowei Yang, Wukun Liu, Yicheng Mei, Dandan Huang, Hai Qian*, Wenlong Huang* and Ronald Gust. Design, Synthesis and Biological Evaluation of 5-Amino-1H-pyrazole-4-carboxamide Derivatives as Potential Antitumor Agents. Letters in Drug Design & Discovery, 2014, 11(6) ,749-755.

  24. Chunlei Tang, Guolong Gu, Baowei Yang, Xuekun Wang, Hai Qian*, Wenlong Huang*, Xiaoyun Zhu and Jing Li. Synthesis and In Vivo Hepatoprotective Activity of Some Novel Andrographolide Derivatives.  Letters in Drug Design & Discovery, 2014, 11(5), 677 – 685.

  25. Chunlei Tang, Guolong Gu, Bin Wang, Xin Deng, Xiaoyun Zhu, Hai Qian* and Wenlong Huang*. Design, Synthesis, and Biological Evaluation of Andrographolide Derivatives as Potent Hepatoprotective Agents.Chem Biol Drug Des, 2014, 83(3), 324–333.

  26. Baowei Yang, Yicheng Mei, Xuekun Wang, Xin Deng, Hai Qian*, Wenlong Huang*. Design, synthesis and biological evaluation of novel peptide MC62 analogues as potential antihyperglycemic agents. European Journal of Medicinal Chemistry, 2014, (73),105-111.

  27. Jing Han, Lidan Sun, Yingying Chu, Zheng Li, Dandan Huang, Xiaoyun Zhu, Hai Qian*,  Wenlong Huang*. Design, Synthesis and Biological activity studies of Novel Dicoumarin-Glucagon-Like Peptide-1 Conjugates.Journal of Medicinal Chemistry, 201356(24), 9955-9968.

  28. Jing Han, Xun Huang, Lidan Sun, Zheng Li, Hai Qian*, Wenlong Huang*, Novel fatty chain-modified glucagon-like peptide-1 conjugates with enhanced stability and prolonged in vivo activity. Biochemical Pharmacology, 2013, 86(2) , 297-308.

  29. Baowei Yang, Wei Chen, Jing Jin, Yicheng Mei, Xuekun Wang, Hong Chen, Sijia Yan, Meng Ru, Guolong Gu, Xin Deng, Hai Qian* and Wenlong Huang*Evaluation of Hypoglycemic and Antioxidative Effects of Synthesized Peptide MC62. Chem Biol Drug Des, 2013, 82(1), 99–105.

  30. Dandan Huang, Xiaoyun Zhu, Chunlei Tang, Yicheng Mei, Wei Chen, Baowei Yang, Jing Han, Hai Qian* and Wenlong Huang*. 3D QSAR Pharmacophore Modeling for c-Met Kinase Inhibitors. Medicinal Chemistry, 2012, 8(6)1117-1125.

  31. Chunlei Tang, Yajuan Liu, Bin Wang, Guolong Gu, Liumeng Yang, Yongtang Zheng, Hai Qian*, and Wenlong Huang*. Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Anti-HIV Agents. Archiv der Pharmazie (Arch. Pharm. Chem. Life Sci). 2012, 345(8), 647–656.

  32. Xiaoyun Zhu, Jianfeng Ji, Dandan Huang, Yan Zhu, Chunlei Tang, Xuan Yang, Hai Qian* and Wenlong Huang*. Discovery, Synthesis and Evaluation of Novel Cholesterol Absorption Inhibitors. Chem Biol Drug Des. 2012, 80(3), 426-433.

  33. Zhi-hong Zou, Xiao-bu Lan, Chun-lei Tang, Xiao-yun Zhu, Bao-min Liu, Hai Qian*, Wen-long Huang* and Yun-man Li. Synthesis and Biological Evaluation of a Series of 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-2-substituted Tetrahydroisoquinoline Derivatives. Medicinal Chemistry, 2012, 84, 711-716.

  34. Chunlei Tang, Xiaoyun Zhu, Dandan Huang, Xin Zanand Baowei Yang, Ying Li,  Xiaoyong Du, Hai Qian*, Wenlong Huang*. A specific pharmacophore model of sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Journal of Molecular Modeling. 2012, 18(6), 2795-2804.

  35. Xin Deng, Xinxin Zhao, Jing Han, Jingjie Wang, Wenlong Huang, Hai Qian* and Liang Ge*. Synthesis and Biological Evaluation of Berberine Derivatives as IBS Modulator. Letters in Drug Design & Discovery, 2012, 9(5), 489-493.

  36. YiCheng Mei, BaoWei Yang, Wei Chen, DanDan Huang, Ying Li, Xin Deng, BaoMing Liu, JingJie Wang, Hai Qian* and WenLong Huang*. A Novel Practical Synthesis of Pazopanib: An Anticancer Drug. Letters in Organic Chemistry, 2012, 9(4), 276-279.

  37. Bin Wang#, Chunlei Tang#, Yaodan Han, Ruzhou Guo, Hai Qian* and Wenlong Huang*. Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives. Medicinal Chemistry, 2012, 8(2), 293-298.

  38. Chunlei Tang, Shu Chen, Hai Qian* and Wenlong Huang*. Interleukin-23: as a drug target for autoimmune inflammatory diseases.IMMUNOLOGY, 2012, 135(2), 112–124.

  39. Wei Chen, Yinghong Zhou, Huibin Zhang, Hai Qian*, Wenlong Huang*, Baowei Yang, Jing Han, Jingpei Zhou, Yushi Chi and Shuaijian Ni. Stability and Bioactivity Studies on Dipeptidyl Peptidase IV Resistant Glucogan-like Peptide-1 Analogues. Protein & Peptide Letters, 2012, 19(2), 203-211.

  40. Wei Chen, Baowei Yang, Huimin Zhou, Lidan Sun, Jie Dou, Hai Qian*, Wenlong Huang*, Yicheng Meia, Jing Han. Structure–activity relationships of a snake cathelicidin- related peptide, BF-15. Peptides, 2011,32 (12) ,2497–2503.

  41. Chunlei Tang, Wenjie Zhang, Xinyang Wang, Bin Wang, Xiaoyun Zhu, Dandan Huang, Xiaoyong Du, Hai Qian*, Wenlong Huang* and Jing Li. Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Antibacterial Agents.  Letters in Drug Design & Discovery, 2011, 8(9), 816-821.

  42. JIN Jing, HUANG Wen-Long*, RAO Guang-Ling*, QIAN Hai, ZHANG Hui-Bin, ZHOU Jin-Pei, WANG Jing-Jie, CHEN Wei, DU Kuo. Total Synthesis of MC2, a Peptide from Momordica Charantia and Its Hypoglycemic Activity. Chinese Journal of Natural Medicines 2011, 9(1): 58-60.

  43. Zhi-hong Zou, Xiao-bu Lan, Hai Qian*, Wen-long Huang*, Yun-man Li. Synthesis and evaluation of furoxan-based nitric oxide-releasing derivatives of tetrahydroisoquinoline as anticancer and multidrug resistance reversal agents.  Bioorganic & Medicinal Chemistry Letters 2011 , 21 (19), 5934–5938

  44. Xiaoyun Zhu, Dandan Huang, Xiaobu Lan, Chunlei Tang, Yan Zhu, Jing Han, Wenlong Huang*, Hai Qian*. The first pharmacophore model for potent G protein-coupled receptor 119 agonist. European Journal of Medicinal Chemistry 2011,46 (7), 2901-2907

  45. Bin Wang, Jing Li, Wen Long Huang*, Hui Bin Zhang, Hai Qian*, Yong Tang Zheng. Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents . Chinese Chemical Letters 2011, 22 (7),781–784.

  46. Liang Ge, jingjie Wang, Xiaoyan Zhang, Huibin Zhang, Hai Qian*, Wenlong Huang and Jinpei Zhou*. Synthesis and Biological Evaluation of Nitric Oxide-releasing Derivatives of Capsaicin as Analgesia Drugs. Letters in Drug Design & Discovery, 2011, 8(1), 76-81.

  47. Hai Qian, Zhixian Fu, Wenlong Huang, Huibin Zhang, Jinpei Zhou, Liang Ge*, Rui Lin*, Haiyan Lin and Xiaowen Hu. Synthesis and Preliminary Biological Evaluation of Capsaicin Derivatives as Potential Analgesic Drugs. Medicinal Chemistry, 2010, 6(4), 205-210.

  48. Jinpei Zhou, Shuaijian Ni, Huibin Zhang*, Hai Qian* , Yushi Chi, Wenlong Huang, Lu Yu, Xiaowen Hu and Wei Chen. Synthesis and Bioactivity Evaluation of Dipeptidyl Peptidase IV Resistant Glucagon-like Peptide-1 Analogues. Protein & Peptide Letters, 2010, 17 (10), 1290-1295.

  49. Hai Qian, Wei Chen, Xiaoyan Zhang, Huibin Zhang, Jinpei Zhou*, Wenlong Huang*, Jing Jin and Dongyan Dai. Synthesis and Biological Evaluation of Dihydroisoquinoline-2(1H)-Carbothioamide Derivatives as TRPV1 Antagonists. Letters in Drug Design & Discovery,2010, 7(4), 235-237.

  50. Hai Qian, Wei Chen, Jin Pei Zhou*, Wen Long Huang*, Hui Bin Zhang, Jing Jin. Total synthesis of endothelin 1 by microwave-assisted solid phase method. Chinese Chemical Letters. 2010, 21(4), 388-390.

  51. Hai Qian, Zhixian Fu, Huibin Zhang, Jinpei Zhou*, Wenlong Huang*, Jing Jin, Wei Chen and Dongyan Dai. Synthesis and Biological Evaluation of Capsaicin Derivatives as Analgesia Drugs. Letters in Drug Design & Discovery,2010, 7(2),122-127.

  52. Jian Feng Ji , Hui Bin Zhang, Wen Long Huang*, Hai Qian*, Jin Pei Zhou. A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors. Chinese Chemical Letters, 2010, 21 (1), 67-69.

  53. Jinpei Zhou, Xiaowen Hu, Huibin Zhang, Hai Qian*, Wenlong Huang, Fan Qi and Yanchun Zhang. Synthesis and Biological Evaluation of 5,6-Dihydro- benzo[c] acridin-7-ol Derivatives as Anti-Alzheimer’s Disease Drugs. Letters in Drug Design & Discovery, 2009, 6(8), 623-628

  54. Jinpei Zhou, Huibin Zhang, Hai Qian*, Liang Lin, Wenlong Huang* and Shuaijian Ni.Synthesis and Biological Evaluation of Aromatase Inhibitors. Letters in Drug Design & Discovery,2009, 6(3), 181-185

  55. Jianfeng Ji, Rui Zhao, Wenlong Huang, Huibin Zhang, Jinpei Zhou*, Yubin Wang and Hai Qian. Synthesis and Bioactivities of 2-Azetidinones as Cholesterol Absorption Inhibitors. Letters in Drug Design & Discovery, 2009(6): 424-427.

  56. Qian, Hai; Huang, Wen Long; Wu, Xiao Ming; Zhang, Hui Bin; Zhou, Jin Pei; Ye, Wen Cai, A new isochroman- 4-one derivative from the peel of Musa sapientum L. and its total synthesis.Chinese Chemical Letters,2007, 18, (10), 1227-1230.