​ZHANG, CAN

Release date:2016-05-25  Release:


 

ZHANG, CAN

Professor of Pharmaceutical Chemistry and Pharmaceutics

School of Academic Institute of Pharmaceutical Science

Phone: 86-25-83271171

Email: zhangcan@cpu.edu.cn

Research Summary

Professor ZHANG’s main research directions are the innovative functional materials and targeted nanosystems for drug delivery. She’s reasearch focused on the synthesis of nanocarrier materials, including the biodegradable, biocompatible and easily synthetic oligopeptide lipids and novel biomaterials, and advanced constructed techniques for drug delivery nanosystems, such as charge conversion, collaborative assembly and cells for drug loading. Based on the mechanisms of drug action and the physiological and pathological conditions in vivo, she developed new targeted drug delivery nanosystems to improve the druggability, effectiveness and safety of drugs, which provided theoretical and practical foundations for their clinical application.


Education

2003   Ph.D., Polymer Chemistry and Physics, Nanjing University

2000   M.S., Pharmaceutical ChemistryChina Pharmaceutical University

1986   B.S., Polymer ChemistryNanjing University


Academic Experience

1986-      Professor of Pharmaceutical Chemistry and Pharmaceutics, China Pharmaceutical University

2006-2006     Visiting Professor, University of Maryland

2002-2002     Senior Visiting Scholar, University of Toyama


Awards and Honors

2011    Second level, for333 high-level talents training project”, Jiangsu Province

2009    First Prize, for natural science, Ministry of Education

2007    Young scientists award nomination, Jiangsu Province

2007    First batch of young and middle-aged scientific and technical leaders, for333 high-level talents training project”, Jiangsu Province

2006   Excellentyoungbackbone teacher, for blue project, Jiangsu Province

2006     New Century Excellent Talents in University, Ministry of Education

2002     Third Prize, for progress in science and technologyJiangsu Province


Publications

1.Zhang Can*, et al. Co-delivery of erlotinib and doxorubicin by pH-sensitive charge conversion nanocarrier for synergistic therapy.J Control Release. 2016, 229:80-92.IF: 7.705

2. Zhang Can*, et al. Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment. Biomaterials. 2015, 73: 284-295. IF: 8.557

3. Zhang Can*, et al.A Collaborative Assembly Strategy for Tumor-Targeted siRNA Delivery. J Am Chem Soc. 2015, 137: 6000-6010. IF: 12.113

4. Zhang Can*, et al.Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration. Angew Chem Int Ed. 2014, 53: 6253-6258. IF: 11.336VIP, cover story

5. Zhang Can*, et al. Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery. Adv Mater. 2012, 24 (27): 3659-3665.  IF: 13.877, cover story