ZHANG, CAN
Professor of Pharmaceutical Chemistry and Pharmaceutics
School of Academic Institute of Pharmaceutical Science
Phone: 86-25-83271171
Email: zhangcan@cpu.edu.cn
Research Summary
Professor ZHANG’s main research directions are the innovative functional materials and targeted nanosystems for drug delivery. She’s reasearch focused on the synthesis of nanocarrier materials, including the biodegradable, biocompatible and easily synthetic oligopeptide lipids and novel biomaterials, and advanced constructed techniques for drug delivery nanosystems, such as charge conversion, collaborative assembly and cells for drug loading. Based on the mechanisms of drug action and the physiological and pathological conditions in vivo, she developed new targeted drug delivery nanosystems to improve the druggability, effectiveness and safety of drugs, which provided theoretical and practical foundations for their clinical application.
Education
2003 Ph.D., Polymer Chemistry and Physics, Nanjing University
2000 M.S., Pharmaceutical Chemistry，China Pharmaceutical University
1986 B.S., Polymer Chemistry，Nanjing University
Academic Experience
1986- Professor of Pharmaceutical Chemistry and Pharmaceutics, China Pharmaceutical University
2006-2006 Visiting Professor, University of Maryland
2002-2002 Senior Visiting Scholar, University of Toyama
Awards and Honors
2011 Second level, for“333 high-level talents training project”, Jiangsu Province
2009 First Prize, for natural science, Ministry of Education
2007 Young scientists award nomination, Jiangsu Province
2007 First batch of young and middle-aged scientific and technical leaders, for“333 high-level talents training project”, Jiangsu Province
2006 Excellentyoungbackbone teacher, for “blue project”, Jiangsu Province
2006 New Century Excellent Talents in University, Ministry of Education
2002 Third Prize, for progress in science and technology，Jiangsu Province
Publications
1.Zhang Can*, et al. Co-delivery of erlotinib and doxorubicin by pH-sensitive charge conversion nanocarrier for synergistic therapy.J Control Release. 2016, 229:80-92.（IF: 7.705）
2. Zhang Can*, et al. Reversal of multidrug resistance by co-delivery of paclitaxel and lonidamine using a TPGS and hyaluronic acid dual-functionalized liposome for cancer treatment. Biomaterials. 2015, 73: 284-295. （IF: 8.557）
3. Zhang Can*, et al.A Collaborative Assembly Strategy for Tumor-Targeted siRNA Delivery. J Am Chem Soc. 2015, 137: 6000-6010. （IF: 12.113）
4. Zhang Can*, et al.Sequential Intra-Intercellular Nanoparticle Delivery System for Deep Tumor Penetration. Angew Chem Int Ed. 2014, 53: 6253-6258. （IF: 11.336，VIP, cover story）
5. Zhang Can*, et al. Multistage pH-Responsive Liposomes for Mitochondrial-Targeted Anticancer Drug Delivery. Adv Mater. 2012, 24 (27): 3659-3665. （IF: 13.877, cover story）
