ZHANG, HUIBIN

Release date:2016-05-25  Release:

 

Huibin Zhang

New Drug Research Center,

China Pharmaceutical University,

Nanjing 210009

P. R. China

E-mail: zhanghb80@163.com

Tel: 13851982598



Date of birth: 1964-12-05

Sex:  Female

Education

09/2000-06/2004

China Pharmaceutical University, Nanjing, P. R. China; Ph.D.

(MedicinalChemistry, Mentor: Prof. Wenlong Huang)

09/1986-06/1989

China Pharmaceutical University, Nanjing, P. R. China; M.S.

(MedicinalChemistry, Mentor: Prof. Sixun Peng)

09/1980-06/1984

China Pharmaceutical University, Nanjing, P. R. China;B.S.

(Pharmaceutical Chemistry)


Research and Teaching


After graduated from China Pharmaceutical University with M.S.,Huibin Zhang entered in the New Drug Research Center, China Pharmaceutical University, and became a lecturer in 1994 and an associate professor in 2001 and a professor in 2008. As director Zhang has finished two projects of China National Key Hi-Tech Innovation Project for the R&D of Novel Drugs(No. 2013ZX09301303-002, 2009ZX09103-094, ) one project of National Natural Science Foundation of China(No.30973638) , and several research grants from the government of Jiangsu Province. Her research area has focused on the discovery of new drugs for metabolic disease including diabetic, cardiovascular and anticancer drugs. She also gave lectures to graduate and undergraduate students.


Main Research Projects:

  1. 2014--, director, the Natural Science Foundation ofJiangsu Province (No. BK 20141349).

  2. 1/2013-12/2015, director, the China National KeyHi-Tech Innovation Project for the R&D of Novel Drugs (No.2013ZX09301303-002).

  3. 1/2012-12/2013, director,the Joint Innovation Fund for Industry University Research in Jiangsu Province - a Prospective Joint Research Project (No.BY2011158).

  4. 1/2010-12/2012, director,the National Natural Science Foundation of China(No.30973638).

  5. 1/2009-12/2011, director, the China National KeyHi-Tech Innovation Project for the R&D of Novel Drugs (No.2009ZX09103-094).

  6. director, the Natural Science Foundation ofJiangsu Province (No. BK97080).

  7. director, the Natural Science Foundation ofJiangsu Province (No. BS99100).

  8. director, the Natural Science Foundation ofJiangsu Province (No. BS2000092).


Peer-Reviewed Articles:

  1. Lingyun Yang, Jian Zhang, Lianghui Si, Li Han, Bo Zhang, Hui Ma, Junhao Xing, Leilei Zhao, Jinpei Zhou andHuibin Zhang*. Synthesis and Biological Evaluation of GPR40/FFAR1 Agonists Containing 3,5-dimethylisoxazole. European Journal of Medicinal Chemistry, 2016, 116: 46-58.

  2. Lingyun Yang, Li Han, Bin Xu, Leilei Zhao, Jinpei Zhou and Huibin Zhang*. Palladium-Catalyzed C-H Bond Ortho Acylation/Annulation with Toluene Derivatives. Asian Journal of Organic Chemistry, 2016, 5(1): 62-65.

  3. Yifei Yang, Fangxia Zou, Leilei Zhao, Yulan Cheng, Xiaoming Zha, Huibin Zhang and Jinpei Zhou*. Combined Pharmacophore Models as Virtual Screening Protocol against BRD4(1) Inhibitor. Medicinal Chemistry Research, 2016, 25(4): 585-595.

  4. Qing Li, Muxing Zhou, Li Han, Qing Cao, Xinning Wang, LeiLei Zhao, Jinpei Zhou and Huibin Zhang*. Design, Synthesis and Biological Evaluation of Imidazo [1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors. Chemical Biology & Drug Design, 2015, 86(4): 849–856.

  5. Qing Li, Qinghua Hu, Xinning Wang, Yang Zong, Leilei Zhao, Junhao Xing, Jinpei Zhou and Huibin Zhang*. Discovery of Novel2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents. Chemical Biology & Drug Design, 2015, 86(4): 509–516.

  6. Qing Li, Junhao Xing, Haibo Cheng, Hui Wang, Jing Wang, Shuai Wang, Jinpei Zhou and Huibin Zhang*. Design, Synthesis, Antibacterial Evaluation and Docking Study of Novel 2-Hydroxy-3-(nitroimidazolyl)-propyl-derived Quinolone. Chemical Biology & Drug Design,2015, 85(1): 79–90.

  7. Junhao Xing, Lingyun Yang, Hui Li, Qing Li, Leilei Zhao, Xinning Wang, Yuan Zhang, Muxing Zhou, Jinpei Zhou andHuibinZhang*. Identification of Anthranilamide Derivatives as Potential Factor Xa Inhibitors: Drug Design, Synthesis and Biological Evaluation. European Journal of Medicinal Chemistry, 2015, 95: 388–399.

  8. Junhao Xing, Qing Li, Shengping Zhang, Haomiao Liu, Leilei Zhao, Haibo Cheng, Yuan Zhang, Jinpei Zhou and Huibin Zhang*. Identification of Dipeptidyl Peptidase IV Inhibitors: Virtual Screening, Synthesis and Biological Evaluation. Chemical Biology & Drug Design, 2014, 84(3): 364–377.

  9. Jing Li*, Huibin Zhang*, Wenlong Huang, Hai Qian and Ying Li. TNF-α Inhibitors with Anti-Oxidative Stress Activity from Natural Products. Current Topics in Medicinal Chemistry, 2012, 12(13): 1408-1421.

  10. Yubin  Wang, Hai Qian, Jinpei Zhou, Huibin Zhang*, Jianfeng Ji and Wenlong Huang*.Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors. Medicinal Chemistry, 2011, 7(6): 534-542.

  11. Yubin Wang, Haiqian, Wenlong Huang, Huibin Zhang* and Jinpei Zhou. Synthesis and Biological Evaluation of Ezetimibe Analogs as Possible Cholesterol Absorption Inhibitors.Letters in Drug Design & Discovery, 2011, 8(6): 500-505.

  12. Wenyuan Liu, Ainan Zhou, Feng Feng*, HuibinZhang*, Jinpei Zhou and Wenlong Huang. Qualitative and Quantitative Studies on Impurities in G004, aPotential Hypoglycaemic Agent, Using Liquid Chromatography, Nuclear Magnetic Resonance and Mass Spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56: 627-632.

  13. Wukun Liu, Jinpei Zhou*, Kerstin Bensdorf, Huibin Zhang, Haoran Liu, YubinWang, Hai Qian,Yanchun Zhang, Anja Wellner, Gerhard Rubner, Wenlong Huang, Cancheng Guo and Ronald Gust*.Investigations on Cytotoxicity and Anti-Inflammatory Potency of Licofelone Derivatives. European Journal of Medicinal Chemistry, 2011, 46(3):907-913.

  14. Wukun Liu,Jinpei Zhou*, Fan Qi,Kerstin Bensdorf, Zhiyu Li,Huibin Zhang, Hai Qian, Wenlong Huang, Xueting Cai, Peng Cao, Anja Wellner, Cancheng Guo and Ronald Gust*. Synthesis and Tumor Cell Growth Inhibitory Effects of 2-Amino-Thiazole-5-Carboxylic Acid Phenylamide Derivatives.Archiv der Pharmazie, 2011, 344(7): 451-458.

  15. Tiancai Wang, Juzhi Wei, Chuansheng Guo, HuibinZhang* and Houxing Fan*. Design, Synthesis  and Anti-Proliferative Studies of a Novel Series of Indirubin Derivatives. Chinese Chemical Letters, 2010, 21(12): 1407–1410.

  16. Jinpei Zhou, Hai Qian, HuibinZhang*, Hui Gao, Wenlong Huang*, Xiaoyun Zhu,Shuaijian Ni and Chuntao Zhang. Synthesis and Biological Evaluation of Benzopyran Derivatives as KATP   Channel Openers. Letters in Drug Design & Discovery, 2010, 7(6): 415-420.

  17. Jinpei Zhou, Shuaijian Ni, HuibinZhang*, Hai Qian*, Yushi Chi, Wenlong Huang, LuYu,Xiaowen Hu and Wei Chen. Synthesis and Bioactivity Evaluation of Dipeptidyl Peptidase IV Resistant Glucagon-Like Peptide-1 Analogues. Protein and Peptide Letter, 2010, 17(10): 1290-1295.

  18. Shuaijian Ni, HuibinZhang, Wenlong Huang*, Jinpei Zhou, Hai Qian and Wei Chen. The Application of an Aryl Hydrazine Linker Prevents β-Elimination Side Products in the SPPS of C-Terminal Cysteine Peptides. Journal of Peptide Science, 2010, 16(6): 309–313.

  19. HuibinZhang, Yaan Zhang, Guanzhong Wu, Jinpei Zhou*, Wenlong Huang* and Xiaowen Hu. Synthesis and Biological Evaluation of Sulfonylurea and Thiourea Derivatives Substituted with  Benzenesulfonamide Groups as Potential Hypoglycemic Agents. Bioorganic & Medicinal  Chemistry Letters, 2009, 19(6): 1740–1744.

  20. Xiangyang Sha, HuibinZhang*, Wenglong huang, Jinpei Zhou and Yinghong Zhou. Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators. Letters in Drug Design & Discovery, 2009, 6(3): 224-227.

  21. Yushi Chi, HuibinZhang*, Wenlong Huang*, Jinpei Zhou, Yinghong Zhou, Hai Qian and Shuaijian Ni. Microwave-Assisted Solid Phase Synthesis, PEGylation, and Biological Activity Studies of Glucagon-Like Peptide-1(7–36) Amide. Bioorganic & Medicinal Chemistry, 2008, 16(16): 7607-7614.

  22. Yu Li, HuibinZhang*, Wenlong Huang and Yunman Li. Design and Synthesis of Tetrahydroisoquinoline Derivatives as Potential Multidrug Resistance Rreversal Agents in Cancer. Bioorganic & Medicinal Chemistry Letters, 2008, 18 (12): 3652-3655.

  23. Yushi Chi, HuibinZhang*, Jinpei Zhou, Wenlong Huang and Shuaijian Ni. Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues, Letters in Organic Chemistry, 2008, 5(5): 399-402.

  24. Jing Li, Wenlong Huang, HuibinZhang*, Xinyang Wang and Huiping Zhou. Synthesis of Andrographolide Derivatives and Their TNF-α and IL-6 Expression Inhibitory Activities. Bioorganic & Medicinal Chemistry Letters, 2007, 17(24): 6891-6894.

  25. HuibinZhang, Yushi Chi, Wenlong Huang. Total Synthesis of Human Urotension-II by Micro Wave-Assisted Solid Phase Method. Chinese Chemical Letters, 2007, 18(8): 902–904.

Patents

  1. HuibinZhang, Jinpei Zhou, Leilei Zhao, Bing Zhang, Bin Xu, Li Han, Yifei Yang. Preparation Method for Triazole Derivatives and Application of the Derivatives as Medicine. CN201511016420.X, CN105541825A.

  2. Jinpei Zhou, Bin Xu, Yifei Yang, HuibinZhang, Leilei Zhao, Bing Zhang, Li Han. Quinoxalinone Compounds Useful in Treatment of Bomodomain Structural Domain Protein Related Diseases and Their Preparation. CN201510759801.0, CN105198871A.

  3. HuibinZhang, Jinpei Zhou, Bing Zhang, Leilei Zhao, Yulan Cheng, Bin Xu, Li Han. Preparation of Imidazo-Pyrazine Compounds and Their Application as Anticancer Drugs. CN201510735938.2, CN105254635A.

  4. HuibingZhang, Lingyun Yang, Yan Lu, Jinpei Zhou, Bo Zhang, Jian Zhang, Li  Han, Lianghui Si. Compounds with 3,5-Dimethylisoxazole as well as Preparation and Use Thereof. CN201510654474.2, CN105198826A.

  5. HuibinZhang, Qingsen Liu, Jinpei Zhou. Preparation of 1,2,3,4-Tetrahydro-6,7-Dimethoxy-Isoquinoline Derivatives as Antidiabetic Agents. CN201110249685.X, CN102358731A.

  6. Jinpei Zhou, HuibinZhang, Wenlong Huang, Feihua Wu, Wukun Liu, Hai Qian, Yanhua Cheng. Preparation of Desloratadine Derivatives for Treating Allergic Diseases. CN201110153330.0, CN102260253A.

  7. Wenlong Huang, HuibinZhang, Bin Wang, Hai Qian, Jing Li, Ronghua Luo, Yongtang Zheng. Medical Application of Andrographolide Derivatives for Treating HIV Infection. CN201010177952.2, CN101829110A.

  8. Wenlong Huang, HuibinZhang, Hai Qian, Jinpei Zhou, Zhixian Fu, Xiaoyan Zhang, Dongyan Dai. Preparation of Capsaicin Derivative as for Treating Pain. CN201010018167.2, CN101774938A.

  9. Wenlong Huang, Jing Jin, Hai Qian, HuibinZhang, Jingjie Wang, Wei Chen, Xin Chen, Jianfeng Ji, Xiaoyun Zhu. Microwave-Assisted Solid Phase Synthesis of Momordica Charantia MC-JJ6 Polypeptide Analogs and its Application. CN200910183319.1, CN101691394.

  10. Wenlong Huang, HuibinZhang, Xiangyang Sha, Yinghong Zhou, Jinpei Zhou, Hai Qian, Yaan Zhang. Preparation of Tetrahydroisoquinoline Derivatives as Antidiabetic Agents. CN200810155077.0, CN101429191.

  11. Wenlong Huang, HuibinZhang, Yushi Chi, Jinpei Zhou, Yinghong Zhou, Hai Qian, Shuaijian Ni. Application of Glucagon-Like Peptide 1 Analogs with High Stability and Activity in Treating Diabetes. CN200810124641.2, CN101337989.

  12. Wenlong Huang, HuibinZhang, Yubin Wang. Preparation of Azacyclobutanone Derivatives, and Pharmaceutical Composition Containing Azacyclobutanone Derivatives. CN200710133305.X, CN101200443.

  13. Wenlong Huang, HuibinZhang, Jing Li, Huiping Zhou. Preparation of Substituted Andrographolide Derivatives and Their Medicine Composition. CN200710019983.3, CN101012211.

  14. Guanzhong Wu, Guangji Wang, HuibinZhang. Use of Sulfonylurea Derivatives in Preparation of Dedicines for Treating Thromboembolic Diseases. CN200410014794.3, CN1569006.

  15. HuibinZhang, Jinpei Zhou, Wenlong Huang,Guanzhong Wu. Preparation of Benzenesulfonamide Derivatives for Reduction of Blood Glucose. CN200410014261.5, CN1560032.

  16. Wenlong Huang, HuibinZhang, Jinpei Zhou, Liwen He. Preparation of 1,2,3,4-Tetrahydroisoquinoline Derivatives for Reversing Multidrug Resistance of Tumor. CN03113261.8, CN1445217.

  17. Wenlong Huang, HuibinZhang, Yunman Li, Jinpei Zhou, Liwen He. Application of Substituted Tetrahydroisoquinoline Derivatives. CN03113262.6, CN1444941.