LIANG, YAN
Distinguished Professor of Pharmacokinetics
School of Pharmaceutical Sciences
Phone: 86-25-83271192
Email: liangyan0679@hotmail.com
Research Summary
Dr. LIANG’s research focuses on the pharmacokinetic & pharmacodynamic studies for Traditional Chinese Medicines based on proteomics and the regulation of intestinal flora. To data, Dr. Liang has innovated multiple new strategies and methods to establish a comprehensive system for the in-depth exploration of DMPK performances of complex Chinese medicines. Particularly, such system has been successfully applied to the research of multiple complex Chinese medicine prescriptions, including Shengmai decoction, Compound Danshen pills and Xuezhikang which have been approved by FDA of the U.S.A. for phase II clinical trials. Besides, Dr. Liang is also engaged in the PK-PD studies for biological macromolecular drugs, including octreotide, Pidotimod, etc.
Education
2007/09–2010/06, China Pharmaceutical University, Pharmacokinetics, Ph.D, Advisor: Guangji Wang.
2003/09–2006/06, China Pharmaceutical University, Pharmacokinetics, M Pharm, Advisor: Yuzhu Hu.
1997/09–2001/06, Jiangsu Institute of Petrochemical Technology, Industry analysis，B.S.
Academic Experience
2016/01– , China Pharmaceutical University, Key Lab of Drug Metabolism & Pharmacokinetics，Distinguished Professor
2014/06– 2015.06 University of Michigan, Visiting scholar
2012/05– 2015.12, China Pharmaceutical University, Key Lab of Drug Metabolism & Pharmacokinetics，Associate Professor
2012/05– , China Pharmaceutical University, Key Lab of Drug Metabolism & Pharmacokinetics，Associate Professor
2010/07–2012/04, China Pharmaceutical University, Key Lab of Drug Metabolism & Pharmacokinetics，Assistant Professor
Awards and Honors
2012 First prize, for progress of Jiangsu Province science and technology, Science and Technology Department of Jiangsu Province
2013 First prize, for Ministry of education, science and technology progress, Ministry of education
2007 Second prize, for national science and Technology Progress Award in 2007, State Council of China
Grants
Projects of National Natural Science Foundation, 81573559, The application of target-proteomics in revealing the active substances and pharmacodynamic mechanisms of traditional Chinese medicine. 2016/01-2020/12、RMB 780,000、In progress.
Projects of National Natural Science Foundation, 81374054, Brain protection mechanism and PK-PD studies for notoginsenosides based on the regulation of gut microbiota. 2014/01-2018/12、RMB 680,000、In progress.
Youth project of National Natural Science Fund，81102881, Development of key technologies for qualitative and quantitative analysis of pharmacokinetic substance of traditional Chinese medicine. 2011/01-2014/12、RMB 220,000、In progress.
"six talent peaks in seventh batches of high level Talents Project" of Jiangsu provincial, evelopment of new theory and new method for the compatibility study of Shengmai, 2011/01-2013/12、RMB 50,000、Finished.
The Jiangsu Province Natural Science Fund Projec, BK20131311, Anti-inflammatory mechanism and PK-PD studies for anguisorba saponins based on the regulation of gut microbiota. 2013/07-2016/06、RMB 100,000、In progress.
Publications
[1] Xing R1, Zhou L1, Xie L1, Hao K, Rao T, Wang Q, Ye W, Fu H, Wang X, Wang G**, Liang Y*, Development of a systematic approach to rapid classification and identification of notoginsenosides and metabolites in rat feces based on liquid chromatography coupled triple time-of-flight mass spectrometry. Analytica Chimica Acta, 2015, 867, (31), 56-66.
[2] Qian Wang 1a,Yan Liang 1a*,Tai Rao 1a, Lin Xie a, Wei Yea, Hanxu Fu a, Lijun Zhou a, Rong Xinga,b, Yuhao Shao a, Jingcheng Xiao a, Dian Kang a, Guangji Wanga*Pharmacokinetic study of octreotide based on LC-MS/MS combining protein precipitation and impurity extraction technique. Bioanalysis. 2015, 7(7): 885-894.
[3] Liang Y1, Zhou Y1, Zhang J, Rao T, Zhou L, Xing R, Wang Q, Fu H, Hao K, Xie L, Wang G. Pharmacokinetic compatibility of ginsenosides and Schisandra Lignans in Shengmai-san: from the perspective of p-glycoprotein.PLoS One. 2014, 9(6):e98717.
[4] Liang Y1, Guan T1, Zhou Y, Liu Y, Xing L, Zheng X, Dai C, Du P, Rao T, Zhou L, Yu X, Hao K, Xie L, Wang G. Effect of mobile phase additives on qualitative and quantitative analysis of ginsenosides by liquid chromatography hybrid quadrupole-time of flight mass spectrometry.J Chromatogr A. 2013, 1297:29-36.
[5] Liang Y1, Zhou Y1, Zhang J, Liu Y, Guan T, Wang Y, Xing L, Rao T, Zhou L, Hao K, Xie L, Wang GJ. In vitro to in vivo evidence of the inhibitor characteristics of Schisandra lignans toward P-glycoprotein.Phytomed. 2013, 20 (11):1030-8.
[6] Liang Y, Wang G, Xie L, Sheng L. Recent development in liquid chromatography/mass spectrometry and emerging technologies for metabolite identification. Curr Drug Metab. 2011;12(4):329-44.
[7] Liang Y, Hao H, Xie L, Kang A, Xie T, Zheng X, Dai C, Hao K, Sheng L, Wang G. Development of a systematic approach to identify metabolites for herbal homologs based on liquid chromatography hybrid ion trap time-of-flight mass spectrometry: gender-related difference in metabolism of Schisandra lignans in rats.Drug Metab Dispos. 2010 Oct;38(10):1747-59.
[8] Liang Y, Hao H, Kang A, Xie L, Xie T, Zheng X, Dai C, Wan L, Sheng L, Wang G. Qualitative and quantitative determination of complicated herbal components by liquid chromatography hybrid ion trap time-of-flight mass spectrometry and a relative exposure approach to herbal pharmacokinetics independent of standards.J Chromatogr A. 2010 23;1217(30):4971-9.
[9] Liang Y, Kang A, Xie T, Zheng X, Dai C, Hao H, A J, Sheng L, Xie L, Wang GJ. Influence of segmental and selected ion monitoring on quantitation of multi-component using high-pressure liquid chromatography-quadrupole mass spectrometry: Simultaneous detection of 16 saponins in rat plasma as a case.J Chromatogr A. 2010 Jun 25;1217(26):4501-6.
[10] Liang Y, Xiao W, Dai C, Xie L, Ding G, Wang G, Meng Z, Zhang J, Kang A, Xie T, Liu Y, Zhou Y, Liu W, Zhao L, Xu J. Structural identification of the metabolites for strictosamide in rats bile by an ion trap-TOF mass spectrometer and mass defect filter technique.J Chromatogr B. 2011, 879 (20): 1819-22.
