YANG, YONG

Release date:2016-06-06  Release:




Yang, Yong

Professor of Pharmacology

Associate Dean of Institute of Pharmaceutical Science

Phone: 86-25-86185622

Email: yy@cpu.edu.cn

Research Summary

Professor Yang’s research focuses on discovery the mechanisms for inflammation-induced cancer and developing of new anti-cancer drugs. He discovered that Gαi1/3 is the key downstream signal molecule of TLR4, an important pattern recognition receptor of innate immunity. He has proved that Gαi1/3 forms a complex with CD14 and its joint molecule Gab1 to take part in PI3K-AKT pathway mediated by TLR4. These results have been published on PNAS (2015). He is the director of Center for New Drug Safety Evaluation and Research of China Pharmaceutical University and has successfully established GLP system with the specification of CFDA. Based on this technological platform, he is hosting a series of new drug evaluation.

Education

2005      Ph.D., Pharmacology, Nanjign Medical Uniersity

2000      B.S., Clinical Medicine, Nanjing Medical Unisersity

Academic Experience

2005-  Professor of Pharmacology, China Pharmaceutical University

Awards and Honors

2015  A CNPHARS-SERVIER young Investigator Awards in Pharmacology CNPHARS

2007  The second prize of Scientific Progress of Jiangsu ProvinceScience and Technology Department of Jiangsu Province

2005  The first prize of Scientific Progress of Jiangsu ProvinceScience and Technology Department of Jiangsu Province


Publications

  1. Xianjing Li#, Duowei Wang#, Zhen Chen#, Ermei Lu, Zhuo Wang, Jingjing Duan, Wei Tian, Yun Wang, Linjun You, Yulian Zou, Yan Cheng, Qingyi Zhu, Xiaojian Wan, Tao Xi, Lutz Birnbaumer *&Yong Yang*. Gαi1 and Gαi3 Regulate Macrophage Polarization by Forming a Complex Containing CD14 and Gab1. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):4731-6Corresponding author

  2. Shuzhen Wang#, Weiquan Xie#, Duowei Wang#, Zhigang Peng, Yan Zheng, Nan Liu, Wen Dai, Yang Wang, Zongqiang Wang, Yong Yang* and Yijun Chen*. Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia. Oncotarget, Advance Publications 2015Corresponding author

  3. Li X, Wang Z, Zou Y, Lu E, Duan J, Yang H, Wu Q, Zhao X, Wang Y, You L, He L, Xi T*, Yang Y*.Pretreatment with lipopolysaccharide attenuates diethylnitrosamine-caused liver injury in mice via TLR4-dependent induction of Kupffer cell M2 polarization. Immunol Res. 2015 Jun;62(2):137-45 Corresponding author

  4. Zhang WB, Wang Z, Su FJin YHLiu HYWang QJYang Y*. Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. J Biol Chem. 2010, 285, 52: 40461–40471.Corresponding author

  5. Qing-yi Zhu, Zhuo Wang, Chao Ji, Yan-li Yang, Yong-hua Jin, Qiu-juan Wang, Zhi-gang Bi*, Gang, Hu*, Yong Yang*. C6-Ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT de-phosphorylation and α-tubulin hyper-acetylation both in vitro and in vivo. Cell Death & Disease. (2011) 2, e117; doi:10.1038/cddis.2010.96. Corresponding author