Release date:2016-06-06  Release:

Biographical sketch

Dr. Ling Peng is a research director at the French National Scientific Research Center (CNRS). She carried her undergraduate study in polymer chemistry with Prof. Chen Rongshi at Nanjing University in China,her Ph.D program in organic chemistry with Prof. Albert Eschenmoser at Swiss Federal Institute of Technology in Zurich Switzerland, and her postdoctoral research in Pharmacywith Prof. Maurice Goeldner at Louis Pasteur University of Strasbourg in France. She was recruited as a research scientist in CNRS in 1997, and promoted as a CNRS research director in 2008. She is currently a group leader at the Interdisciplinary Center on Nanoscience in Marseille (CINaM) in France, and guest professor at China Pharmaceutical University. She is working actively in developingmultifunctional dendrimers as intelligent nanomaterials for drug and gene delivery, molecular probes for exploring biological events and drug discovery. She has co-authored more than 100 scientific papers in reputed international journals including PNAS, EMBO, Nature Communication, Chem Rev, Angew Chem In Ed, Chem Soc Rev etc. Dr. Ling Peng has also coordinated and participated different European projects under the frame of EU FP7 EuroNanoMed program. She is currently the member of Editorial Advisory Board of Molecular Pharmaceutics, section editor for drug delivery of Current Medicinal Chemistry and Assistant Editor of New Journal of Chemistry.

Selected publications

1. Laurent, S.; Chen, H.; Bedu, S.; Ziarelli,F.; Peng, L.; Zhang, C-C. "A non-metabolizable analogue of the Krebs-cycle intermediate 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. strain PCC 7120", Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 9907-9912. (Cover Story)

2. Zhou, J. H.; Wu, J.Y.; Hafdi, N.; Behr, J.-P.; Erbacher, P.; Peng, L. "PAMAM dendrimers for efficient siRNA delivery and potent gene silencing", Chem. Commun. 2006, 2362-2364. (Hot Paper)

3.  Herincs, Z.; Chakrabandhu, K.; Dost, B.; Peng, L.; Conchonaud, F.; Marguet, D.; He, H-T.; Hueber, A-O. "Palmitoylation is required for Fas to trigger cell death signaling", EMBO J. 2007, 26, 209-220.

4. Xia, Y.; Liu, Y.; Wan, J.; Wang, M.H.; Rocchi, P.; Qu,F.Q.;  Iovanna, J.L.; Peng, L. "A novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer", J. Med. Chem.2009, 52, 6083-6096

5. Yu, T.Z.; Liu, X.X.; Bolcato-Bellemin, A-L.; Wang,Y.; Liu, C.; Erbacher, P.; Qu, F.; Rocchi, P.; Behr, J-P.; Peng, L. "An amphiphilic dendrimer for effective siRNA delivery and gene silencing in vitro and in vivo", Angew. Chem. Int. Ed.2012, 51, 8478-8484. (Frontispiece)

6. Xia, Y.; Viel, S.; Wang,Y.; Ziarelli, F.; Laurini, E.; Posocco, P.; Qu, F.Q.; Fermeglia, M.; Pricl, S.; Peng, L. “Rationalizing the FS interaction discovered within a tetrafluorophenylazido-containing bola-phospholipid”, Chem. Commun. 2012, 48, 4284-4286. (Inside Front Cover)

7. Chen, H.; Viel, S.; Ziarelli, F.; Peng, L. 19F NMR: a valuable tool for studying biological events”, Chem. Soc. Rev. 2013, 42, 7971 – 7982. (Back Cover)

8. Xia, Y.; Peng, L. “Photoactivatable lipid probes to study biomembranes using photoaffinity labeling”, Chem. Rev. 2013,  113, 7880 – 7929 (Cover Story).

9. Liu, X.X.; Zhou, J.H.; Yu, T.Z.; Chen, C.; Cheng, Q.; Sengupta, K.; Huang, Y.Y.; Li, H.T.; Liu, C.; Wang,Y.; Posoco, P.; Wang, M.H.; Cui, Q.; Giorgio, S.; Fermeglia, M.; Qu, F.Q.; Pricl, S.; Shi, Y.H.; Liang, Z.C.; Rocchi, P.; Rossi, J.J.; Peng, L. “Adaptive amphiphilic dendrimer based nanoassemblies as robust and versatile siRNA delivery systems”, Angew. Chem. Int. Ed. 2014, 53, 11822-11827. (Highlighted in Nature Chemistry)

10.Wei, T.; Chen, C.; Liu, J.; Liu C.; Posocco, P.; Liu, X.X.; Cheng, Q.; Huo, S.; Liang, Z.C.; Fermeglia, M.; Pricl, S.; Liang, X.-J.; Rocchi, P.; Peng, L. “Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance”, Proc Natl Acad Sci U S A, 2015, 112, 2978-2983.