ZHANG, ZUNJIAN

Release date:2016-06-06  Release:

ZHANG, ZUNJIAN

Professor of Pharmaceutical Analysis

Director of Institute of Pharmaceutical Science

Institute of Pharmaceutical Science

Phone: 86-25-83271454

Email: zzj@cpu.edu.cn

Research Summary

Professor ZHANG’s research focuses on the pharmaceutical analysis including drug quality evaluation and control in vitro & in vivo, pharmacokinetics and metabolism as well as analytical chemical toxicology. He recently published a paper entitled "A pharmacometabonomic approach using predose serum metabolite profiles reveals differences in lipid metabolism in survival and non-survival rats treated with lipopolysaccharide"(Metabolomics, 2016) which considers to understand inter-animal variability in toxic response to lipopolysaccharide. Professor ZHANG has published more than 100 SCI papers.

Education

1994  Ph.D.,  Pharmaceutical Analysis, China Pharmaceutical University

1983  B.S.,   Pharmaceutical Analysis, Nanjing College of Pharmacy

Academic Experience

2013-      Professor of Pharmaceutical Analysis, Institute of Pharmaceutical Science

2009-2013  Professor of Pharmaceutical Analysis, School of Pharmacy,

2004-2012  Professor of Pharmaceutical Analysis, Center for Instrumental Analysis

1997-2004  Associate Professor of Pharmaceutical Analysis, Center for Instrumental Analysis

1994-1997  Lecture of Pharmaceutical Analysis, Center for Instrumental Analysis

1986-1988  Clinical Pharmacist, Xuzhou Institute of Medical Science

1983-1986  Assistant Engineer, Tianjin Institute of Pharmaceutical Industry

Publication (2011-):

1.  Rui Song, Lei Xu, Fengguo Xu, Haijuan Dong, Yuan Tian and Zunjian Zhang*:

Metabolic analysis of rhubarb extract by rat intestinal bacteria using liquid chromatography-tandem mass spectrometry, Biomedical Chromatography, 2011,25:417-426

2.  TIAN Yuan, FENG Shudan, HUANG Meihua and ZHANG Zunjian*:

Determination of glucocorticosteroids added in cosmetics illegally by LC-MS/MS,

J. of China Pharmaceutical University, 2011,42(1):53-57

3.  Ying Cheng, Zunjian Zhang*, Yuan Tian,Wenjing Li and Wei Wei:

Quantification of voriconazole in human plasma by high-performance liquid chromatography– electrospray ionization mass spectrometry: Application to a bioequivalence study

Arzneimittel-Forschung (Drug Research), 2011,61(2):132-139

4.  Jun Huang, Yuan Tian, Zunjian Zhang*, Jinheng Li and Xiaomei Cao:

Pharmacokinetics and bioequivalence study of two mosapride citrate formulations after single-dose administration in healthy Chinese male volunteers

Arzneimittel-Forschung (Drug Research), 2011,61(3):167-172

5.  Xiaolei Ren,Yuan Tian, Zunjian Zhang*, Yun Chen, Lili Wu and Jun Huang:

Determination of cetirizine in human plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: Application to bioequivalence study,

Arzneimittel-Forschung (Drug Research), 2011,61(5):287-295

6.  Meihua Huang, Yuan Tian, Zunjian Zhang*, Hongwen Zhang and Hui Lin:

Determination of propiverine hydrochloride in human plasma by high performance liquid chromatography-tandem mass spectrometry: Application to the pharmacokinetic study of a sustained release formulation. Arzneimittel-Forschung (Drug Research), 2011,61(9):494-501

7.  Xiaoheng Tan, Qiaogen Zou and Zunjian Zhang*:

Achievements on drug delivery system of dihydropyridine,

Progress in Pharmaceutical Sciences (YAOXUE JINZHAN), 2011,358:360-366

8.  Zhenbin Feng, Qiaogen Zou, Xiaoheng Tan, Wenjun Che and Zunjian Zhang*:

Determination of fenticonazole enantiomers by LC-ESI-MS/MS and its application to pharmacokinetic studies in female rats

Arzneimittel-Forschung (Drug Research), 2011,61(10):587-593

9.  Fengguo Xu, Li Zou, Ying Liu, Zunjian Zhang* and Choon Nam Ong*:

Enhancement of the capabilities of liquid chromatography-mass spectrometry with derivatization: General principles and applications, Mass Spectrometry Reviews, 2011, 30:1143-1172

10.  Ziyan Hu, Qiaogen Zou, Jixin Tian, Lili Sun and Zunjian Zhang*:

Simultaneous quantitation of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection : application to bioequivalence study,

Journal of Chromatography B2011, 879(32): 3937-3942

11.  GUO Junping,TIAN Yuan, HUANG Mei-hua, CAO Jing and ZHANG Zun-jian*:

Studies on dissolution and in vitro-in vivo correlations of propiverine hydrochloride sustained release capsules, J. of China Pharmaceutical University, 2011,42(6):522-526

12.  Xueyu Zang, Yuan Tian, Zunjian Zhang*, Jianzhong Rui and Xiaowei Cao:

Pharmacokinetics and bioequivalence study of two digoxin formulations after single-dose administration in healthy Chinese male volunteers

Arzneimittel-Forschung (Drug Research), 2011,61(11):601-604

13.  Yin Huang, Hui Lin, Rui Song, Yuan Tian and Zunjian Zhang*:

Optimization of dispersive liquid-liquid microextraction for analysis of levonorgestrel in water samples using uniform designAnalytical Methods2011,3:857-864

14.  Min Bian,Zunjian Zhang *and Hao Yin:

Effects and mechanism characterization of ionic liquids as mobile phase additives for the separation of matrine-type alkaloids by liquid chromatography

Journal of Pharmaceutical and Biomedical Analysis, 2012, 58163-167

15.  Min Bian,Hao Yinand Zunjian Zhang *:

Separation of matrine-type alkaloids with ionic liquids and triethylamine as mobile phase,

J. of Nanjing University of Technology(Natural Science Edition), 2012,34(1):117-120

16.  Lei Xu, Rui Song, Ji-Xin Tian, Yuan Tian, Guo-Qiang Liu and Zun-Jian Zhang*:

Analysis of saikosaponins in rat plasma by anionic adducts-based liquid chromatography tandem mass spectrometry method, Biomedical Chromatography, 2012, 26:808-815

17.  SONG Rui, CHENG Ying, TIAN Yuan and ZHANG Zunjian*:

A validated solid-phase extraction HPLC method for the simultaneous determination of gallic acid, catechin and epicatechin in rhubarb decoction,

Chinese J. of Natural Medicines, 2012, 104):275-278

18.  SONG Rui, TIAN Yuan and ZHANG Zunjian

Comparison of the metabolism of four processed rhubarb aqueous extract by rat intestinal bacteria in vitro, China J. of Chinese Materiaa Medica, 2012, 3712):1755-1760

19.  Dong Haijuanand ZHANG Zunjian*:

Simultaneous Determination of 3 Components of Diterpenoids in Andrographis paniculata and Chuanxinlian Injection by HPLC, Chinese J. of Modern Applied Pharmacy, 2012, 29(4):349-352

20.  Lei Xu, Ji-Xin Tian, Rui Song, Guo-Qiang Liu, Yuan Tian and Zun-Jian Zhang*:

LC-MS/MS determination and comparison of saikosaponin a, b2, c, d in crude and processed radix bupleuri by vinegar, J. of China Pharmaceutical University, 2012, 434):334-340

21.  Zhang Lu-Yang, Tian Yuan, Shen Xiao-Hang, Luo Jiang and Zhang Zun-Jian*:

Hydrophilic Interaction Chromatography and Its Applications in Quantitative Bioanalysis,

J. of China Pharmaceutical University, 2012, 434):379-384

22.  Yin Huang, Yuan Tian, Zunjian Zhang* and Can Peng:

A HILIC–MS/MS method for the simultaneous determination of seven organic acids in rat urine as biomarkers of exposure to realgar, Journal of Chromatography B, 905(2012),37-42

23.  SUN Li-li, ZOU Qiao-gen, ZHANG Zun-jian*:

Studies on the polymorphism of agomelatine,

West China J. of Pharmaceutical Sciences, 2012, 27(5):533-536

24.  Jing Cao, Zunjian Zhang*, Yuan Tian, Yuanyuan Li and Jianzhong Rui:

Liquid chromatography-mass spectrometry method for the determination of olanzapine in human plasma and application to a bioequivalence study

Current Pharmaceutical Analysis, 201283):247-254

25.  Peng Can, Lv Meng-ying, Li Geng, Tian Ji-xin, Tian Yuan and Zhang Zun-jian*:

Research progress on analytical methods of bile acids profiles in calculus bovis and its substitutes, Chinese Traditional and Herbal Drugs,2013445):632-636

26.  Ji-xin Tian, Can Peng, Lei Xu, Yuan Tian and Zunjian Zhang *:

In vitro metabolism study of Strychnos alkaloids using high-performance liquid chromatography combined with hybrid ion trap/time-of-flight mass spectrometry,

Biomedical Chromatography, 2013;27:775–783

27.  HUANG Yin, XU Fengguo*, ZHANG Wei, ONG Choonnam and ZHANG Zunjian**:

Progress for pharmacometabolomics its applications,

J. of China Pharmaceutical University, 2013, 442):105-112

28.  Geng Li, Xueyu Zhang, Yuan Tian, Zunjian Zhang *, Jianzhong Rui and Xiaoman Chu:

Pharmacokinetics and Bioequivalence Study of Two Indapamide Formulations after Single-dose Administration in Healthy Chinese Male VolunteersDrug Research, 2013;63:13–18

29.  LI Yuanyuan, TIAN Yuan, CHEN Dongjun, WU Xiaoming and ZHANG Zunjian*:

Isolation and Identification of An Unknown Impurity Contained in Ambroxol Hydrochloride Glucose Injection, Chinese Journal of Pharmaceuticals, 2013444):379-382

30.  CHENG Ying, HUNG Yin, TIAN Yuan, XU Lei, LIU Guoqiang and ZAHNG Zunjian*:

Assessment of effects of Radix Bupleuri and vinegar-baked Radix Bupleuri on cytochrome 450 activity by a six-drug cocktail approach, Chinese J. of Natural Medicines, 2013, 11(3)302-308

31L-F LuoY TianH-M GuoG LiZ-J Zhang*

Pharmacokinetics and bioequivalence of two ibuprofen sustained-release formulations after single and multiple doses in healthy Chinese male volunteersDrug Research, 2013;63:468-472

32X.HuangZ.-Z. JiangT. WangZ. LiL.-Y. Zhang*, Z.-J. Zhang*

Pharmacokinetics, Distribution and Excretion of PNA in Rat by Liquid Chromatography Mass Spectrometry MethodDrug Research, 2013; 63:540–544

33.  Peng Can, Wang Min, Lv Meng-ying, Tian Yuan and Zhang Zun-jian*:

Determination of bile acids, bilirubin and taurine in rat plasma by LC-MS/MS,

J. of China Pharmaceutical University, 2013, 444):343-347

34X.HuangZ.-Z. JiangW.-W. TangY. XiaoL.-Y. Zhang*, Z.-J. Zhang*

A Validated Method for Quantifying Entecavir in Biological Matrices and Its Application in a Pharmacokinetic Study in Rats and DogsDrug Research, 2013; 63:644–649

35.  Can Peng, Meng-ying Lv, Ji-xin Tian, Yin Huang, Yuan Tian and Zun-jian Zhang*:

Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in ratsJournal of Pharmacy and Pharmacology2013; 65:1064–1072

36.  Guoqiang Liu, Yuan Tian, Geng Li, Lei Xu, Rui Song and Zunjian Zhang*:

Metabolism of saikosaponin a in rats: Diverse oxidations on the aglycone moiety in liver and intestine besides hydrolysis of glycosidic bonds, Drug Metabolism and Disposition

2013; 41:622–633

37.  Yin Huang, Yuan Tian, Geng Li, Yuanyuan Li, Xinjuan Yin, Can Peng, Fengguo Xu*and Zunjian Zhang*: Discovery of safety biomarkers for realgar in rat urine using UFLC-IT-TOF/MS and 1H NMR based metabolomicsAnalytical and Bioanalytical Chemistry2013;405:4811–4822

38.  YAO Lu-lu, ZOU Qiao-gen, SUN Li-li and ZHANG Zun-jian*:

Structural elucidation of the impurities in imidafenacin and its tablets,

Chinese J. of New Drugs, 2013, 2213):1472-1477

39.  DU Wei, ZOU Qiao-gen, SUN Li-li and ZHANG Zun-jian*:

Determination of residual solvents in cinacalcet hydrochloride by Static Headspace GC,

West China J. of Pharmaceutical Sciences, 2013,2 8(3):290-292

40Luo LifangTian YuanGuo HuimingZhang Zunjian*

Pharmacokinetic interaction between ibuprofen and lafutidine in rats,

North China J. of Pharmaceutical Science(BeiFang YaoXue)s, 2013, 108(6):76

41HUANG XinTANG Wei-wei, JIANG Zhen-zhouHE Ming, ZHU Yao-jun, HE Xin, ZHANG Lu-yong and ZHANG Zun-jian*

Tissue Distribution of Paclitaxel Liposome in Rats and Tumor Bearing Nude Mice,

Pharmaceutical and Clinical Research, 2013, 21(2):129-132

42HUANG XinTANG Wei-wei, JIANG Zhen-zhouHE Ming, ZHU Yao-jun, HE Xin, ZHANG Lu-yong and ZHANG Zun-jian*

Quantitation of paclitaxel in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetic study, Chinese J. of Pharmaceutical Analysis, 2013, 33(11):1868-1872, 1881

43.  Ji-xin Tian, Yuan Tian, Lei Xu, Ji Zhang, Tao Lu and Zunjian Zhang*:

Characterization and identification of dihydroindole-type alkaloids from processed Semen Strychni by liquid chromatography coupled with electrospray ionization ion trap time-of-flight mass spectrometryPhytochemical Analysis, 2014, 25:36-44

44. Ji-xin Tian, Ming Wang, Lei Xu, Yuan Tian*, Rui Song, Fengguo Xu and Zunjian Zhang**:Metabolism of brucine: the important metabolic pathways of dihydroindole-type alkaloid for excretion in ratsBioanalysis2014, 6(2):137-149

45.  Yuanyuan Li, Mengrui Wang, Qianqian Zhang, Yuan Tian, Fengguo Xu*and Zunjian Zhang**:

Chemical differentiation of Da-Cheng-Qi decoction and its three analogous decoctions using UFLC-IT-TOF/MS-based chemomic and chemometric approachAnalytical Methods2014, 6:1720-1727

46.  Wang Ming, Huang Yin, Zhang Wei, Zhang Zunjian* and Xu Fengguo**:

Discussion on Bottleneck Problems in Data Acquisition and Pre-Processing of MetabolomicsProgress in Pharmaceutical Sciences2014, 38(2):81-88

47.  Peng Can, Tian Jixin, Lv Mengying, Huang Yin, Tian Yuan and Zhang Zunjian*:

Development and Validation of a Sensitive LC-MS/MS Method for Simultaneous Determination of Multicomponent Contents in Artificial Calculus Bovis, Journal of Chromatographic Science2014, 52(2):128-136

48.  Mengru Wang,Yuanyuan Li, Yin Huang, Yuan Tian,Fengguo Xu*and Zunjian Zhang**:

Chemomic and chemometric approach based on ultra-fast liquid chromatography with ion trap time-of-flight mass spectrometry to reveal the difference in the chemical composition between Da-Cheng-Qi decoction and its three constitutional herbal medicines,

Journal of Separation Science, 2014 May;37(9-10):1148-54

49.  YIN Xinjuan, YANG Yan, TIAN Yuan*, TIAN Jixin, YU Pei and ZHANG Zunjian2**:

Effect of simvastatin on the metabolism and pharmacokinetics of felodipine in rats,

J. of China Pharmaceutical University, 201445(4):450-455

50.  Min Wang, Jinfeng Fu, Mengying Lv, Yuan Tian, Fengguo Xu, Rui Song*and Zunjian Zhang**:

Effect of wine-processing and acute blood stasis on the serum pharmacochemistry of rhubarb: a possible explanation for processing mechanism,

Journal of Separation Science2014, 37(18):2499-2503

51.  YANG Yan, YIN Xin-Juan, GUO Hui-Min, WANG Ru-Lin, SONG Rui, TIAN Yuan* and ZHANG Zun-Jian**:  Identification and comparative analysis of the major chemical constituents in the extracts of single Fuzi herb and Fuzi-Gancao herb-pair by UFLC-IT-TOF/MS,

Chinese J. of Natural Medicines, 2014,12(7):542-553

52.  LV Meng-ying, HUANG Wan-qiu, TIAN Yuan, HUANG Yin, ZHANG Zun-jian*XU Feng-guo**:The Fragmentation Patterns of Polychlorinated Biphenyls,

J. of Chinese Mass Spectrometry Society, 201435(6):524-529

53.  Yuan Tian, Jing Cao, Lifang Luo, Zunjian Zhang* and Pengcheng Ma:

Determination of zofenopril and its active metabolite in human plasma using high-performance liquid chromatography combined with a triple-quadruple tandem mass spectrometerJournal of Chromatography Science, 201553 (2): 253-262

54.  Min Wang, Jinfeng Fu, Huimin Guo, Yuan Tian, Fengguo Xu, Rui Song*and Zunjian Zhang**:

Discrimination of crude and processed rhubarb products using a chemometric approach based on ultra fast liquid chromatography with ion trap/time-of-flight mass spectrometry

Journal of Separation Science2015, 38(3): 395-401

55.  Jing Wang, Hongyan Fan, Yong Wang, Xu Wang, Pei Zhang,Jiaqing Chen, Yuan Tian, Wei Zhang, Fengguo Xu*and Zunjian Zhang**:

Metabolomic study of Chinese medicine Huang Qin Decoction as an effective treatment for irinotecan-induced gastrointestinal toxicityRSC Advances, 2015, 5: 26420-26429

56.  Hui Zhao, Xiao-dong She, Xia-xia Yu, Jin-feng Fu, Yun Chen, Yuan Tian and Zun-jian Zhang*:

Quantification of iodiconazole by LC-MS/MS, a new topical transdermal cream, in dermatophytosis patients’ plasmaBioanalysis2015,77:895-905

57.  MengyingLv, Ben-qin Tang, Jing Teng, Jingyu Liang,Fengguo Xu, Zunjian Zhang* and Jianbo Sun**Chemotaxonomic significance of limonoids and triterpenoids from Dictamnus angustifolius G. Don ex Sweet, Biochemical Systematics and Ecology2015,59:311-313

58.  MengyingLv, Ping Xu, Yuan Tian, Jingyu Liang, Yiqiao Gao, Fengguo Xu, Zunjian Zhang* and

Jianbo Sun**Medicinal uses, phytochemistry and pharmacology of the genus Dictamnus,

Journal of Ethnopharmacology,2015,171:247-263

59.  Mengying Lv, Jianbo Sun, Min Wang, Wanqiu Huang, Hongyan Fan, Fengguo Xu* and Zunjian Zhang**: GC-MS based metabolomics study of stems and roots of Ephedra sinica

Journal of Pharmaceutical and Biomedical Analysis, 2015,114(3):49-52

60.  Mengying Lv, Wanqiu Huang, Zhipeng Chen, Hulin Jiang, Jiaqing Chen, Yuan Tian, Zunjian Zhang* and Fengguo Xu**:  Metabolomics techniques for nanotoxicity investigations,

Bioanalysis2015,712:1527-1544

61.  Min Wang, Yuan Tian, Mengying Lv, Fengguo Xu, Zunjian Zhang*and Rui Song**:

Targeted quantitative analysis of anthraquinone derivatives by high-performance liquid chromatography coupled to tandem mass spectrometry to discriminate crude and processed rhubarb samplesAnalytical Methods2015,7:5375-80

62.  Jinfeng Fu, Min Wang, Huimin Guo, Yuan Tian, Zunjian Zhang*and Rui Song**:

Profiling of Components of Rhizoma et Radix Polygoni Cuspidati by High Performance Liquid Chromatography with UV Diode-array Detector and Ion trap/time-of-flight Mass Spectrometric Detection.  Pharmacognosy Magazine, 2015, 11(43)486-501

63.  Mengying Lv, Jiaqing Chen, Jianbo Sun, Yiqiao Gao, Wanqiu Huang, Fengguo Xu* and Zunjian Zhang**: Metabolomics based on liquid chromatography with mass spectrometry reveals the chemical difference in the stems and roots derived from Ephedra sinicaJournal of separation science, 2015, 38(19): 3331-3336

64.  Min Wang, Guangnan Hu, Yuan Tian, Zunjian Zhang* and Rui Song**:

Influence of wine-processing on the pharmacokinetics of anthraquinone aglycones and glycosides from rhubarb in hyperlipidemic hamsters, RSC Advances, 2016, 6: 24871-24879

65.  LV Meng-Ying, SUN Jian-Bo, WANG Min, FAN Hong-Yan, ZHANG Zun-Jian*, XU Feng-Guo**:Comparative analysis of the stems and roots of Ephedra sinica via GC-MS-based plant metabolomics, Chinese J. of Natural Medicines, 201614(2): 133-140

66.  Pei Yu, Hongcong Qiu, Min Wang, Yuan Tian, Zunjian Zhang* and Rui Song**:

In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes,

xenobiotica, 2016, 4:1-9

67.  Lin Zhang, Rulin Wang, Yuan Tian* and Zunjian Zhang**:

Determination of torasemide in human plasma and its bioequivalence study by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry

Journal of Pharmaceutical Analysis, 2016,6:95-102

68.  Ruiting Li, Peifang Liu, Peijia Liu, Yuan Tian, Yunfei Hua, Yiqiao Gao, Hua He, Jiaqing Chen, Zunjian Zhang* and Yin Huang**:

A novel liquid chromatography tandem mass spectrometry method for simultaneous determination of branched-chain amino acids and branched-chain α-keto acids in human plasma, Amino Acids,2016,48(6):1523-1532

69.Die Dai, Yuan Tian, Huimin Guo, Pei Zhang, Yin Huang, Wei Zhang, Fengguo Xu* and Zunjian Zhang**: A pharmacometabonomic approach using predose serum metabolite profiles reveals differences in lipid metabolism in survival and non-survival rats treated with lipopolysaccharideMetabolomics2016, DOI 10.1007/s 11306-015-0892-6

70.  Rulin Wang, Lin Zhang, Zunjian Zhang* and Yuan Tian**:

Comparison of ESI and APCI LC-MS-MS methodsA case study of levonorgestrel in human plasma, Journal of Pharmaceutical Analysis, 2016,doi: 10.1016/j.jpha.2016.03.006.

71.  Rulin Wang, Lin Zhang, Yuan Tian* and Zunjian Zhang**:

Simultaneous determination of levonorgestrel and two endogenous sex hormones in human plasma based on LC-MS/MS, Bioanalysis, 2016,doi: 10.4155/bio-2015-0036