YANG, JIN

Release date:2016-06-06  Release:



YANG, JIN

Professor of Pharmacokinetics

Deputy Director of Department of Pharmacology

college of pharmacy

Phone: 86-25-3271386

Email:cpu_yj@163.com

Research Summary

Professor YANG’s research focuses on the model-based drug development, ie. IVIVE, PBPK, PK/PD, popPK, have published 60 related scientific papers.

Education

2008       Ph.D., pharmacology, China Pharmaceutical University

2003       M.S., pharmacology, China Pharmaceutical University

1993       B.S., pharmacology, China Pharmaceutical University

Academic Experience

2013-      Professor of Pharmacology Division

2006-2013  Associate Professor of Pharmacology Division

1993-2006 Lecturer of

Publications

1.Ye Zhang, Lu Shen, Ying Zhanb, Qing-Qing Xiao, Jin Yang(Correspondence Author). Development and validation of an LC–MS/MS method for the determination of PMEA, the active metabolite of a novel anti-HBV drug of pradefovir mesylate and adefovir dipivoxil in human serum and urineapplication to a clinical pharmacokinetic study. Journal of Chromatographic Science, 2015, 1 –9 doi: 10.1093/chromsci/bmv172

2.Qingqing Xiaoa, Liling Tangb, Ruijuan Xuc, Wei Qiand,* and Jin Yang(Correspondence Author),* Physiologically based pharmacokinetics model predicts the lack of inhibition by repaglinide on the metabolism of pioglitazone  Biopharm. Drug Dispos. (2015) 603-612

3.Liupeng Wang, Chunyong Wu, Lu Shen , Haiyan Liu, Ying Chen, Fang Liu, Youqun Wang, and Jin Yang(Correspondence Author) Evaluation of drug–drug interaction between henagliflozin, a novel sodium-glucose co-transporter 2 inhibitor, and metformin in healthy Chinese males  Xenobiotica, 2015 Nov 26:1-6

4.Fan G, Cao Y, Yang J(Correspondence Author). In vitro inhibition and induction of human cytochrome P450 enzymes by SIPI5357, a potential antidepressant. Biopharm Drug Dispos. 2015 Sep 36: 364–372

5.Jing Z, Kuang L, Liu N, Yang J(Correspondence Author). LC-MS/MS for the simultaneous determination of polar endogenous ADMA and CML in plasma and urine from diabetics. Bioanalysis. 2015 May;7(10):1261-71

6.Xu R, Liu X, Yang J(Correspondence Author). A semi-physiologically based pharmacokinetic pharmacodynamic model for glycyrrhizin-induced pseudoaldosteronism and prediction of the dose limit causing hypokalemia in a virtual elderly population. PLoS One. 2014 Dec 2;9(12): e114049. doi: 10.1371/journal.pone.0114049. eCollection 2014

7.Biao Yu, Pengcheng Ma, Linwen Yuan, Dingding Chen, and Jin Yang(Correspondence Author) Evaluation of change in the skin concentration of tazarotene and betamethasone dipropionate based on drug–drug interaction for transdermal drug delivery in miniature pig. Xenobiotica. 2014 Nov 20:1-5.

8.Xu R, Wang Q, Zhang J, Zang M, Liu X, Yang J(Correspondence Author). Changes in pharmacokinetic profiles of acetaminophen and its glucuronide after pretreatment with combinations of N-acetylcysteine and either glycyrrhizin, silibinin or spironolactone in rat. Xenobiotica. 2014 Jun;44(6):541-6.

9.Min Zang, Xiaoqiang Liu, Lin Chen, Qingqing Xiao, Linwen Yuan, Jin Yang(Correspondence Author)  Determination of BmKCT-13, a chlorotoxin-like peptide, in rat plasma by LC–MS/MS: Application to a preclinical pharmacokinetic study  Journal of Chromatography B, 947–948 (2014) 125– 131

10.Liqing Kuang, Zhiqiang Jing, Jing Wang, Liyuan Ma, Xiaoqiang Liu, Jin Yang (Correspondence Author)  Quantitative determination of ε-N-Carboxymethyl-L-lysine in Human Plasma by Liquid Chromatography-Tandem Mass Spectrometry. Journal of Pharmaceutical and Biomedical AnalysisJournal of Pharmaceutical and Biomedical Analysis 90 (2014) 1–6

11.Shuming LI, Xiangyang WANG, Wei LI, Yang CHU. Jiahua GUO, Xiaohui MA,  Jin YANG (Correspondence Author) Characterization of Metabolites in Rat after Administration of Danshensu by Liquid Chromatography-tandem Mass Spectrometry Lat. Am. J. Pharm. 2013:32 (4): 582-6  

12.Yuan Lu • Jinbo Yang • Haiyan Zhang • Jin Yang. (Correspondence Author) Prediction of Warfarin Maintenance Dose in Han Chinese Patients Using a Mechanistic Model Based on Genetic and Non-Genetic Factors. Clinical Pharmacokinetics. (2013) 52:567–581

13.R. Xu, Q. Xiao, Y. Cao, J.Yang(Correspondence Author) Comparison of the Exposure of Glycyrrhizin and its Metabolites and the Pseudoaldosteronism after Intravenous Administration of Alpha- and Beta-glycyrrhizin in Rat. Drug Res (Stuttg). 2013 Jul 17

14.Xu R, Zhang X, Yang J(Correspondence Author), Liu X, Davey AK, Wang J. Effects of glycyrrhizin on biliary transport and hepatic levels of glutathione in rats. Biopharm Drug Dispos. 2012 Apr 17. doi: 10.1002/bdd.1789.

15.Min Zhang, Jin Yang(Correspondence Author), Lei Tao, Lingjun Li, Pengcheng Ma, and John Paul Fawcett, Acarbose Bioequivalence: Exploration of New Pharmacodynamic Parameters  AAPS J. 2012 Jun;14(2):345-51.

16.Feng-Juan Zhao, Hong Tang, Qing-Hua Zhang, Jin Yang, (Correspondence Author), Andrew K., Daveyc, Ji-ping Wang. Salting-out homogeneous liquid–liquid extraction approach applied in sample pre-processing for the quantitative determination of entecavir in human plasma by LC–MS Journal of Chromatography B, 881–882 (2012) 119– 125

17.Guo-fu LI, Kun WANG, Rui CHEN, Hao-ru ZHAO, Jin YANG, Qing-shan ZHENG, Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal  function using whole-body physiologically based pharmacokinetic modeling. Acta Pharmacologica Sinica  (2012) 33: 1359–1371

18.Chen Yanxiao Xu Ruijuan Yang Jin(Correspondence Author)  Organic anion and cation transporters are possibly involved in renal excretion of entecavir in rats  Life Sciences 89 (2011) 1–6

19.Xiong Yu ; Yang yuqing ; Yang jin, Dr.; chai hong yan; Li ying; Yang Jing , Dr. Tectoridin, an isoflavone glycoside from the flower of Pueraria lobata, prevents acute ethanolinduced liver steatosis in mice,  Toxicology. 2010 Sep 30;276(1):64-72.

20.Qing-Hua Zhang, Jin Yang(Correspondence Author)  Food effect on the pharmacokinetics of entecavir from dispersible tablets following oral administration in healthy Chinese volunteers  Arzneimittelforschung 2010;60(10):640–644

21.L. Chen, J. Yang(Correspondence Author), A. K. Davey, Y.-X. Chen, J.-P. Wang, and X.-Q. Liu Efects of diammonium glycyrrhizinate on the pharmacokinetics of aconitine in rats and the  potential mechanism Xenobiotica, 2009; 39(12): 955–963

22.Jin Yang, Ying He Pharmacokinetic Properties of S-adenosylmethionine after  Oral and intravenous administration of its Tosylate disulfate  salt: a Multiple-dose, Open-Label, Parallel-Group study in Healthy Chinese volunteers  Clinical Therapeutics Volume 31, Number 2, 2009311-320

23.Jin Yang, Liang Zhou, JipingWang, GuangjiWang, Andrew K Davey The Disposition of Diammonium Glycyrrhizinate and Glycyrrhetinic Acid in the Isolated Perfused Rat Intestine and Liver   Planta Medica 2008; 74: 1351–1356

24.Li Ding, Xin Huang, Jin Yang, Xiaojie Bian. Determination of glycyrrhetic acid in human plasma by lc-esi-ms Journal of pharmaceutical and biomedical analysis 40(2006) 758~762

25.Yanwei Wu, Bingren Xiang , Jin Yang Determination of nifuratel in human plasma by hplc and study on its pharmacokinetics Journal of Chromatographic Science vol 43 ,April 2005 p179~182s

26.Din L, Li L, Tao P, Yang J, Zhang Z.  Quantitation of tamsulosion in human plasma by liquid chromatography-electrospray ionization mass spectrometry Journal of  Chromatography B. 767(2002)75-81

27.Tu J, Wang L, Yang J, Fei H, Li X Formulation and Pharmacokinetic Studies of Acyclovir Controlled-release Capsules Drug Development and Industrial Pharmacy, 27(7)687-692(2001)