WANG, CHEN

Release date:2016-07-04  Release:


Wang, Chen

Professor of Molecular Cell Biology

Dean of School of Life Science and Biotechnology


Phone: 86-25-86185395

Email: cwang1971@cpu.edu.cn


Research Summary

Professor Wang’s research focuses on understanding the dynamic interactions between hosts and microbes, and elucidating the relevant signaling pathways (NF-B, IRF3) from the molecular and cellular perspectives. He isespecially interested in addressing the novel functions of ubiquitin and ubiquitin-like proteins in modulating innate immunity. He recently published a serial of ground-breaking papers uncovering how the cytosolic microbial RNAs or DNAs are recognized, and then trigger the activation of antimicrobial and inflammatory signaling pathways (RLR, cGAS-STING) to restrict microbial infections and initiate adaptive immunity. The insights from these studies will be instrumental for identifying/developing novel therapeutic drug targets against Inflammation, Autoimmunity, and Cancer.


Education

1998   Ph.D,  Molecular Biology, Shanghai Institute of Biochemistry, Chinese Academy of Sciences

1993   B.S.,   Biochemistry, College of Life Science,

China Agricultural University

Academic Experience

2016-      Professor of Molecular Cell Biology

School of Life Science and Biotechnology

China Pharmaceutical University

2002-2016  Professor of Molecular Cell Biology

Institute of Biochemistry and Cell Biology,

Shanghai Institutes for Biological Sciences,

Chinese Academy of Sciences

1998-2002  Postdoctoral Fellow of Molecular Biology

University of Texas Southwestern Medical Center, USA

Awards and Honors

2015   CAS-BHPBExcellentMentorship, CAS

2009   “百千万人才工程” 国家级人选,人事部

2009   “优秀学科带头人”,上海市

2005   “中青年突出贡献奖”,国务院

2003   The Outstanding Young Scientists Program,

National Natural Foundation of China

2002   TheRisingStarYoungScientists Program,

Shanghai Municipal Goverment

2002   One Hundred Talents Program, Chinese Academy of Sciences

Major Publications

  1. Wei Chen, Senlin Li, Huansha Yu, Xing Liu, Lulu Huang, Qiang Wang, Heng Liu, Ye Cui, Yijun Tang, Peng Zhang, Chen Wang* (2016): ER adaptor SCAP translocates and recruits IRF3 to perinuclear microsome induced by cytosolic microbial DNAs. PLOS Pathogens. Vol 12(2): e1005462. doi:10.1371/ journal.ppat.1005462.

  2. Xing Liu, Chen Wang* (2016): The emerging roles of the STING adaptor protein in immunity and diseases. Immunology. Vol 147: 285-291. Invited Review.

  3. Qiang Wang, Xing Liu, Chen Wang* (2015): Cytosolic sensing of aberrant DNAs: Arming STING on Endoplasmic Reticulum. Expert Opinion OnTherapeutic Targets. Vol 19: 1397-1409. Invited Review.

  4. Rui Ge, Yi Zhou, Rui Peng, Rui Wang, Yunbin Zhang, Chunfu Zheng, Chen Wang* (2015): Conservation of the STING-mediated cytosolic DNA sensing pathway in zebrafish. Journal of Virology. Vol 89: 7696-7706.

  5. Bo Wei, Ye Cui, Yuefeng Huang, Heng Liu, Lin Li, Mi Li, Kang-Cheng Ruan, Qin Zhou, Chen Wang* (2015): Tom70 mediates Sendai virus-induced apoptosis on mitochondria. Journal of Virology. Vol 89: 3804-3818.

  6. Hao Gu, Qidong Li, Shan Huang, Weiguang Lu, Fangyuan Cheng, Ping Gao, Chen Wang, Lin Miao, Yide Mei & Mian Wu (2015): Mitochondrial E3 ligase March5 maintains stemness of mouse ES cells via suppression of ERK signalling. Nature Communications. doi:10.1038/ncomms8112.

  7. Xing Liu, Qiang Wang, Youdong Pan, Chen Wang* (2015): Sense and Respond to Cytosolic Viruses Invasion: an Orchestra of Kaleidoscopic Ubiquitinations. Cytokine & Growth Factors Review. Vol 26:379-387. Invited Review.

  8. Yi Zhou, Rui Ge, Rui Wang, Feng Liu, Yuefeng Huang, Heng Liu, Yan Hao, Qin Zhou, Chen Wang* (2015): UXT potentiates angiogenesis via attenuating the Notch signaling.Development. Vol 142: 774-786.

  9. Shi Jiao, Zhen Zhang, Chuanchuan Li, Min Huang, Zhubing Shi, Yanyan Wang, Xiaomin Song, Heng Liu, Chunyang Li, Min Chen, Wenjia Wang, Yun Zhao, Zhengfan Jiang, Hongyan Wang, Catherine CL Wong, Chen Wang*, Zhaocai Zhou* (2015): The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor molecule TRAF6. Nature Immunology. Vol 16: 246-257.

  10. Qiang Wang, Xing Liu, Ye Cui, Yijun Tang, Wei Chen, Senlin Li, Huansha Yu, Youdong Pan, Chen Wang*(2014): The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING. Immunity. Vol 41: 919-933.

  11. Yuefeng Huang, Heng Liu, Senlin Li, Yijun Tang, Bo Wei, Huansha YuChen Wang* (2014):MAVS-MKK7-JNK2 defines a novel apoptosis signaling pathway during virus infection.PLOS Pathogens. Vol 10(3): e1004020. doi:10.1371/journal.ppat.1004020.

  12. Xing Liu, Wei Chen, Qiang Wang, Heng Liu, Yan HaoChen Wang*(2013): Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6.PLOS Pathogens. Vol 9(6): e1003480. doi:10.1371/journal.ppat.1003480.

  13. Xing Liu, Wei Chen, Qiang Wang,Chen Wang* (2013): Dynamic Regulation of Innate Immunity by ubiquitin and ubiquitin-like proteins.Cytokine & Growth Factors Review. Vol 24:559-570. Invited Review.

  14. Yuefeng Huang, Heng Liu, Rui Ge, Yi Zhou, Xiwen Lou,Chen Wang* (2012): UXT-V1 facilitates the formation of MAVS antiviral signalsome on mitochondria. Journal of Immunology. Vol 188:358-366.

  15. Xin-Yi Liu, Wei Chen, Bo Wei, Chen Wang* (2011): Interferon Induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.Journal of Immunology. Vol 187: 2559-2568.

  16. He-Xin Shi, Xing Liu, Qiang Wang, Pei-Pei Tang, Xin-Yi Liu,Yu-Fei Shan, Chen Wang*(2011): Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action.PLOS Pathogens. Vol 7(5): e1002057. doi:10.1371/journal.ppat.1002057.

  17. Chen Wang*, Xin-Yi Liu, Bo Wei(2011): Mitochondria, An Emerging Platform Critical For Host Antiviral Signaling. Expert Opinion OnTherapeutic Targets. Vol 15: 647-665. Invited Review.

  18. Yuefeng Huang, Liang Chen,Yi Zhou, Heng Liu, Jueqing Yang, Zhenggang Liu, and Chen Wang* (2011): UXT-V1 protects cells against TNF-induced apoptosis through modulatingcomplex II formation. Molecular Biology of the Cell.Vol 22: 1389-1397.

  19. Xiwen Lou, Shaogang Sun, Wei Chen, Yi Zhou, Yuefeng Huang, Xing Liu, Yufei Shan, Chen Wang*(2011): Negative feedback regulation of NF-B action by CITED2 in nucleus.Journal of Immunology. Vol 186:539-548.

  20. Xin-Yi Liu, Bo Wei, He-Xin Shi, Yu-Fei Shan,Chen Wang* (2010): Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. Cell Research. Vol20:994-1011.

  21. Yujie Tang, Gongxun Zhong, Lianhui Zhu, Xing Liu, Yufei ShanHuapeng Feng, Zhigao Bu, Hualan Chen, Chen Wang*(2010): Herc5 attenuates Influenza A virus by catalyzing ISGylation of viral NS1 protein.Journal of Immunology. Vol 184: 5777-5790.

  22. He-Xin Shi, Kai Yang, Xing Liu, Xin-Yi Liu, Bo Wei, Yu-Fei Shan, Lian-Hui Zhu, Chen Wang* (2010): Positive Regulation of IRF3 Activation by Herc5 via ISG15 Modification.Molecular and Cellular Biology. Vol 30: 2424-2436.

  23. Kai Yang, He-Xin Shi, Xin-Yi Liu, Yu-Fei Shan, Bo Wei, She Chen, Chen Wang* (2009): TRIM21 is essential to sustainIFN Regulatory Factor 3 Activation during antiviral response. Journal of Immunology. Vol 182: 3782-3792.

  24. Bianhong Zhang, Meng Li, Liang Chen, Kai Yang, Yufei Shan, Lianhui Zhu, Shaogang Sun, Lin Li andChen Wang* (2009):The TAK1-JNK cascade is required for IRF3 function in the innate immune response. Cell Research. Vol 19: 412-428.

  25. Hong Nian, Wei Zhang, Hexin Shi, Qingzhen Zhao, Qi Xie, Shangying Liao, Yan Zhang, Zhuqiang Zhang, Chen Wang* and Chunsheng Han* (2008): Mouse RING finger protein Rnf133 is a testis-specific endoplasmic reticulum-associated E3 ubiquitin ligase. Cell Research. Vol 18: 800-802.

  26. Shaogang Sun,Yujie Tang, Xiwen Lou, Lianhui Zhu, Kai Yang, Bianhong Zhang, Hexin Shi andChen Wang* (2007): UXT is a novel and essential co-factor in NF-B transcriptional enhancesome. Journal of Cell Biology. Vol 178: 231-244.

  27. Ying Lin, Yujie Tang, Hongliang Zong, Jianxin Gu, Weiwen Deng,Chen Wang* and Bing Sun* (2007): Cyclin G associated kinase interacts with interleukin 12 receptor2 and suppresses interleukin 12 induced IFN-production. FEBS Letters. Vol 581: 5151-5157

  28. Kai Yang, Hexing Shi, Rong Qi, Shaogang Sun, Yujie Tang, Bianhong Zhang and Chen Wang* (2006):Hsp90 regulates activation of IRF3 and TBK1 stabilization in Sendai virus infected cells. Molecular Biology of the Cell. Vol17: 1461-1471.

  29. Lirong Diao, Bianhong Zhang, Chenghao Xuan, Yunqi Geng, Chen Wang*(2005): Activation of the c-Jun N-terminal kinase (JNK) pathway by the HSV-1 immediate early protein ICP0. Experimental Cell Research. Vol 308: 196-210.

  30. Lirong Diao, Bianhong Zhang, Junkai Fan, Xiang Gao, Shaogang Sun, Kai Yang, Dan Xin, Naihe Jin, Yunqi Gengand Chen Wang*(2005): Herpes virus proteins ICP0 and BICP0 can activate NF-κB by catalyzing IκBα ubiquitination. Cellular Signalling. Vol 17: 217-229.

  31. Kai Yang, Jianmei Zhu, Shaogang Sun, Yujie Tang, Bianhong Zhang, Lirong Diao and Chen Wang*(2004)The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination. Biochemical and Biophysical Research Communications. Vol 324: 432-439.

  32. Chen Wang, Li Deng, Mei Hong, Giridhr.Akkaraju, Jun-IchiroInoue, Zhijian J.Chen (2001): TAK1 is an ubiquitin-dependent kinase of MKK and IKK. Nature.Vol 412: 346-351.

  33. Li Deng, Chen Wang, Erika Spencer, Liyong Yang, Amy Braun, Jianxin You, Clive Slaughter, Cecile Pickart, and Zhijian J. Chen (2000): Activation of the IB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain. Cell.Vol 103: 351-361.

(* Corresponding Author)