SUN, LI

Release date:2017-12-28  Release:主页英文版


SUN, LI                                        

Associate professor of pharmacology

China Pharmaceutical University

Phone: 86-25-83271057

Email: sunli@cpu.edu.cn


Research Summary

Associate Professor Sun’s research is mainly engaged in the tumor pathogenesis and nature antitumor drug discovery research. Mainly studies are focused on the belowaspacts:

  1. Discovery the mechanisms for tumor microenvironment, extracellular matrix and cancer metastasis, especially in breast cancer and lung cancer. Our research group discovered that lysyl hydroxylase 2 (PLOD2) is the key downstream signal molecule of EGFR, an important mutational activation receptor in non-small-cell lung cancer (NSCLC). We have proved that PLOD2 regulated by the transcription factor FOXA1 via PI3K/AKT signaling pathway, revealing the novel mechanism in the tumor microenvironment (TME) for metastasis and the potential therapeutic strategy for NSCLC. These results have been published on CDD (2017).

  2.  Combination of nature anti-cancer drugs with clinical first-line chemotherapy drugs, to improve the effectiveness and decrease its side-effects. Our group recently published two papers entitled “Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of EGF receptor in vitro and in vivo" and “DT-13 synergistically enhanced vinorelbine-mediated mitotic arrest through inhibition of FOXM1-BICD2 axis in non-small cell lung cancer cells”, both combination of DT-13 with chemotherapy drugs to increase their anti-cancer effect.

Education

2013

Postdoc

Pharmacology

MD Anderson Cancer Center

2006

PhD

Pharmacology

China pharmaceutical University

2000

M.S

Pharmacology

China pharmaceutical University

1992

B.S.

Clinical Medicine

Jiangsu University

Academic Experience

2010-present

Associate professor of Pharmacology

China pharmaceutical University

2003-2006

Lecturer

National Drug Screening Center

1996-2000

Resident Physician

Mai-gaoqiao hospital


Publications

  1. Du H, Hou X, Chen Y, Huang Y, Wei X, Yu X, Feng S, Shi X, Lin S, Yuan S* and Sun L*. PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC. Cell Death and Disease. Accepted.

  2. Du H, Pang M, Hou XY, Yuan ST, Sun L. PLOD2 in cancer research. Biomed Pharmacother. 2017; 90:670-676.

  3. Li H, Sun L, Li H, Lv X, Herve Semukunzi, Li R, Yu J, Yuan S* and Lin S*. DT-13 synergistically enhanced vinorelbine-mediated mitotic arrest through inhibition of FOXM1-BICD2 axis in non-small-cell lung cancer cells. Cell Death and Disease. 2017; 8, e2810; doi:10.1038/cddis.2017.209.

  4. Khan GJGao YGu MWang LKhan SNaeem FYousef BARoy DSemukunzi HYuan S*, Sun L*. TGF-β1 Causes EMT by regulating N-Acetyl Glucosaminyl Transferases via Downregulation of Non Muscle Myosin II-A through JNK/P38/PI3K pathway in lung cancer. Curr Cancer Drug Targets. 2017 Aug 7. doi: 10.2174/1568009617666170807120304.

  5. Yu XW, Lin S, Du HZ, Zhao RP, Feng SY, Yu BY, Zhang LY, Li RM, Qian CM,   Luo XJ, Yuan ST*, Sun L*. Synergistic combinatin of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of egf receptor in vitro and in vivo.Oncotarget. 2016; 7(22): 32990–33003.

  6. Li HY, Sun L, de Carvalho EL, Li X, Lv X, Khan GJ, Semukunzi H, Yuan S*, Lin S*. DT-13, a saponin monomer of dwarf lilyturf tuber, induces autophagy and potentiates anti-cancer effect of nutrient deprivation.Eur J Pharmacol. 2016; 781: 164-72.

  7. Wei XH, Liu Y, Zhao RP, Du HZ, Mao TT, Yu BY, Li RM, Yuan ST*, Sun L*. DT-13 attenuates human lung cancer metastasis via regulating NMIIA activity under hypoxia condition. Oncology Reports, 2016, 36 (2): 991-999.  

  8. Du HZ, Huang Y, Hou XY, Yu XW, Lin SS, Wei XH, Li RM, GJ Khan, Yuan ST*, Sun L*. DT-13 inhibits cancer cell migration by regulating NMIIA indirectly in the tumor microenvironment Oncology Reports, 2016, 36 (2): 721-728.  

  9. Pankova DChen YTerajima MSchliekelman MJBaird BNFahrenholtz MSun LGill BJVadakkan TJKim MPAhn YHRoybal JDLiu XParra Cuentas ERRodriguez JWistuba IICreighton CJGibbons DLHicks JMDickinson MEWest JLGrande-Allen KJ, Hanash SMYamauchi MKurie JM*.  Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.Mol Cancer Res. 2016 Mar;14(3):287-95.

  10. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M*, Kurie JM*. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015 Feb 9. pii: 74725. doi: 10.1172/JCI74725.

  11. Wang Yurong, Wang Bin, Guerram, Mounai, Sun Li, Shi Wei, TianCongcong, Zhu Xiong, Jiang Zhenzhou*, Zhang Luyong*. Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho Aactivatio. Oncotarget. 2015, 6(30): 29497-512.

  12. Sun L, Yang Q, Wang P, Liu D, Liang W, Lin S*, Yuan S*. The influence of YS-1 on the Dll4-Notch1 signaling pathway. ActaBiochimBiophys Sin. 2014 Jan;46(1):56-64.

  13. Lin SS, Fan W, Sun L*, Li FF, Zhao RP, Zhang LY, Yu BY, Yuan ST*. The saponin DT-13 inhibits gastric cancer cell migration through down-regulation of CCR5-CCL5 axis.Chin J Nat Med. 2014 Nov; 12(11):0833-0840.

  14. Sun L, Liu J, Lin SS, Shi WT, Zhu J, Liang G, Yuan ST*. Potent anti-angiogenic activity of B19--a mono-carbonyl analogue of curcumin. Chin J Nat Med. 2014 Jan;12(1):8-14.

  15. Ren-Ping Z, Sen-Sen L, Yuan ST, Yu BY, Bai XS, Sun L*, Zhang LY*. DT-13, a saponin of dwarf lilyturf tuber, exhibits anti-cancer activity by down-regulating C-C chemokine receptor type 5 and vascular endothelial growth factor in MDA-MB-435 cells, Chin J Nat Med. 2014 Jan; 12(1): 0024-0029.

  16. Sun L,Liu Y,Lin S,Shang J,Liu J,Li J,Yuan S*,Zhang L*. Early growthresponse gene-1 and hypoxia-inducible factor-1α affect tumor metastasis via regulation of tissue factor. Acta Oncol.2013 May; 52 (4):842-851.

  17. Dong W , Li Y, Li X, Hu M, Aodengqimuge, Sun L, Guo N, Yuan S*, Song L*. p85α mediates NFAT3-dependent VEGF induction in the cellular UVB response. J cell Sci. 2013 Mar 15; 126(Pt 6):1317-1322.

  18. R Zhao, L Sun, S Lin, X Bai, B Yu, ST Yuan*, LY Zhang*. The saponin monomer of dwarf lilyturf tuber, DT-13, inhibits angiogenesis under hypoxia and normoxia via multi - targeting activity Oncology Reports, 2013/4. 29(4), 1379-1386.

  19. Koumtebaye E, Sun N, Hu WF, Lin SS, Sun L*, Yuan ST*. Antitumor activety of Xiaoaiping injection on human gastric cancer SGC-7901 cells. Chin J Nat Med. 2012, 10(5): 0339−0346, 10(5), 339-346.

  20. Fang D, Sun L, Lin S, Zhou L, Su N, Yuan S*, Yu B*. Vinorelbine inhibits angiogenesis and 95D migration via reducing hypoxic fibroblast stromal cell-derived factor 1 secretion. Exp Biol Med. 2012 Sep; 237 (9): 1045 - 1055.

  21. Lin S, Wan S, Sun L, Hu J, Fang D, Zhao R, Yuan S*, Zhang L*. Chemokine C-C motif receptor 5 and C-C motif ligand 5 promote cancer cell migration under hypoxia. Cancer Sci. 2012 May; 103(5):904-912.

  22. Zhu J, Sun L, Lin S, Zhao R, Zhou L, Fang D, Chen L, Liu J, Shi W, Zhang L, Yuan S*. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. J Exp Clin Cancer Res. 2012 Mar 31;31:31. doi: 10.1186/ 1756-9966 -31.

  23. Jiang W, Kou J, Yuan S, Sun L, Yu B*. A simplified and high-throughput chromogenic assay for testing tissue factor-dependent procoagulant activity. J Biomol Screen. 2011 Mar; 16 (3):295-302.

  24. Zhou L, Sun L, Lin S, Fang D, Zhao R, Zhu J, Liu J, Chen L, Shi W, Yuan S*, Zhu D*. Inhibition of angiogenic activity of hypoxic fibroblast cell line MRC-5 in vitrobytopotecan. Med Oncol. 2010 Nov 9

  25. Li Sun, Sensen Lin, Renping Zhao, Boyang Yu, Shengtao Yuan*,and Luyong Zhang*. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue factor. Biol. Pharm. Bull. 2010, 33(7) 1192-1198.

  26. Sun Li, Lin SS, Yu BY, Yuan ST*, Zhang LY*. High-throughput screening model for tissue factor inhibitor and effect of DT-13 on anti-tumor metastasis. Chin J Nat Med. Nov. 2010 Vol. 8 No. 6 466-470.

  27. Lin S, Sun L, Hu J, Wan S, Zhao R, Yuan S, Zhang L. Chemokine CXC motif receptor 6 contributes to cell migration during hypoxia. Cancer Lett. 2009 Jun 28; 279(1):108-17.

  28. Lin SS, Sun L, Zhang YK, Zhao RP, Liang WL, Yuan ST, Zhang LY. Topotecan inhibits cancer cell migration by down-regulation of chemokine CC motif receptor 7 and matrix metalloproteinases,Acta Pharmacologica Sinica. 2009 May; 30(5):628-36.

  29. Sun li, Fang XK.et al. 4-Hydroxyisoleucine improves glucose metabolism and insulin signal transduction in hepG-2 cells. Drug Development Research. 2006; (66):234.

  30. Sun li. Dai dezai. Inhibition of optical isomers of CPU86017 on vascular smooth muscle contraction caused by Ca2+. Chinese journal of natural medicines. 2006; 4(6): 456-9.