Chensiyu

Chen Siyu, Deputy Director of the Department of Biochemistry at the School of Life Sciences and Technology, China Pharmaceutical University, is a professor, doctoral supervisor, and Chief Young Scientist of the National Key Research and Development Program. His main focus is on the research of Target Discovery and Intervention Strategies for NAFLD. In this direction, the applicant has published 18 papers as the first/corresponding author (including co authorship) in international mainstream academic journals such as Adv Sci, Nat Commun, Gut Microbes, etc., with nearly a thousand citations, and has been granted 1 national patent and applied for 6 patents; Hosted 8 projects including the National Key R&D Program for Young Scientists, the National Natural Science Foundation for Young Scientists, and the Jiangsu Province Excellent Youth Fund; He is a young member of the Metabolism Committee of the Chinese Society of Biochemistry, a director of the Jiangsu Society of Developmental Biology, a young editorial board member of the Journal of China Pharmaceutical University and Progress in Biochemistry and Biophysics, a guest editor of Front Endocrinol, and has reviewed for top international journals such as J Hepatol and ACS Nano multiple times; Has won an excellent doctoral thesis in Jiangsu Province.

1. Chen S^$, Zhang W^$, Sun C^$, Song M^$, Liu S, Xu M, Zhang X, Liu L & Liu C*. (2020). Systemic Nanoparticle-Mediated Delivery of Pantetheinase Vanin-1 Regulates Lipolysis and Adiposity in Abdominal White Adipose Tissue. Advanced Science, 7(14): 2000542.【一区，IF=15.84】

2. Song M, Zhang S, Tao Z, Li J, Shi Y, Xiong Y, Zhang W, Liu C & Chen S*. (2021). MMP-12 siRNA improves the homeostasis of the small intestine and metabolic dysfunction in high-fat diet feeding-induced obese mice. Biomaterials, 278: 121183.【一区，IF=12.479】

3. Chen S^$, Feng M^$, Zhang S, Dong Z, Wang Y, Zhang W & Liu C*. (2019). Angptl8 mediates food-driven resetting of hepatic circadian clock in mice. Nature Communications, 10(1): 1-16.【一区，IF=11.878】

4. Shi Y^$, Zou Y^$, Xiong Y^$, Zhang S^$, An X, Liu C, Zhang W* & Chen S*. (2021). Host Gasdermin D restrains systemic endotoxemia by capturing Proteobacteria in the colon of high-fat diet-feeding mice. Gut Microbes, 13(1): 1946369.【一区，IF=10.245】

5. Song M^$, Dong S^$, An X, Zhang W, Shen N, Li Y, Guo C, Liu C, Li X* & Chen S*. (2022). Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers. Journal of Controlled Release, 345: 744-754.【一区，IF=11.467】

6. Chen S^$, Zhang W^$, Li X, Cao Z, Liu C*. (2024). DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1. Cell Death & Disease, 15(1): 78.【一区，IF=9.0】

7. Zhang W^$, Dong Z^$, Xu M, Zhang S, Liu C* & Chen S*. (2020). SWI/SNF complex subunit BAF60a represses hepatic ureagenesis through a crosstalk between YB-1 and PGC-1α. Molecular Metabolism, 32, 85–96. 【一区，IF=8.1】

8. Song M, Xia W, Tao Z, Zhu B, Zhang W, Liu C* & Chen S*. (2021). Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy. Drug Delivery, 28(1), 594–606. 【二区，IF=6】

9. Zhang W, Shao W, Dong Z, Zhang S, Liu C* & Chen S*. (2019). Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death & Disease, 10(6), 404.【一区，IF=9】

1. Hosted the National Key R&D Program for Young Scientists (Project No. 2022YFA08070200), with a budget of 4 million from December 2022 to July 2011.

2. Hosted the Excellent Youth Fund of Jiangsu Provincial Natural Science Foundation (BK20220151), with a grant of 500000 yuan, from July 2022 to May 2025.

3. Hosted the National Natural Science Foundation of China Youth Fund Project (No. 31800992), 260000, 2019 01-2021.12.

4. Hosted the Jiangsu Provincial Natural Science Foundation Youth Fund Project (No. BK20180554), with a budget of 200000 yuan, from July 2018 to June 2021.

5. Hosted the launch fund for the introduction of high-level talents at China Pharmaceutical University, with a budget of 1 million from January 2018 to November 2023.

6. Hosted the Youth Teacher Development Promotion Project at the School of Life Science and Technology, China Pharmaceutical University, with a budget of 100000 yuan from July 2020 to December 2021.

7. Hosted the Central Basic Business Expense Project of China Pharmaceutical University, 80000 yuan, January 2018 to December 2019