Guowei

Professor Guo focuses on mechanistic study on influence factors during T cell differentiation and development in AID, biological molecular design and protein drug，nucleic acid drug development based on cytokine and T cell misbalance in autoimmune diseases, two Investigational New drugs were approved by Chinese Health Agency，four National Natural Science Foundation were supported and five patents were granted. Distinguished in strategies and methods on T cell immunotherapy for cancer.

Wei Guo* et al.,Turning anecdotal irradiation-induced anticancer immune responses into reproducible in situ cancer vaccines via disulfiram/copper-mediated enhanced immunogenic cell death of breast cancer cells. Cell Death Dis. 2024 Apr 27;15(4):298.

Wei Guo* et al.,Broadening anticancer spectrum by preprocessing and treatment of T- lymphocytes expressed FcγRI and monoclonal antibodies for refractory cancers. Front Immunol. 2024 Jun 17;15:1400177.

Wei Guo* et al.,In vitro and in vivo assessment of structural integrity for HPCD complex@Liposome nanocomposites from ocular surface to the posterior segment of the eye. Carbohydrate Polymers. 2023,315:120960.

Wei Guo* et al., Anti−IL-12/23 p40 antibody attenuates chronic graft-versus-host disease with lupus nephritis via inhibiting Tfh cell in mice  Biomedcine & Pharmacotherapy, 2020. 2020;129:110396

A new strategy for the treatment of systemic sclerosis with multifunctional targeted fusion protein complex STDS/siRNA(PI, National Natural Science Foundation, 01/2025-12/2028, RMB550,000)

Evaluation of the therapeutic effect of biopharmaceuticals(Jiangsu Province Leading Science Foundation, 01/2021-12/2024, RMB1000,000)

Mechanistic insights into thIL12rb1 treating SLE regulated by succinylation of Bcl-6 (PI, National Natural Science Foundation, 01/2020-12/2023, RMB700,000)

Mechanistic insights into rhIL23R-CHR/Fc targeting Th17 cell regulated by lncRNA in autoimmune diseases (PI, National Natural Science Foundation, 01/2016-12/2019, RMB696,000)

Teaching Excellence Award by Shanghai Fosun Pharmaceutical Group,

High-Level Talents in Six Industries, The Government of Jiangsu Province,

 333 High level Talent Training Project in Jiangsu Province,

 the young academic leaders of the Green and Blue Project in Jiangsu universities