Hangtaijun

Dr. Hang’s areas of research emphases include the development of new comprehensive approaches for the quality control analysis and evaluation of both the chemical drugs and traditional Chinese medicines, even in vitro and in vivo comparative pharmacokinetic and pharmacodynamic investigations for drugs based on quality by design requirements, using modern analytical, biochemical and chemo-metrical techniques.

1、 Educational Experience

Dr. Hang began his university study in 1980, received his S.B. in chemistry in 1984 and his Master degree in Analytical Chemistry in 1987, both from Nanjing University of China.

2、 Working Experience

Dr. Hang joined the faculty in the School of Pharmacy, China Pharmaceutical University in June 1987 and began his work as an analytical pharmacist ever since.

He worked as a Visiting Scholar in the Department of Pharmaceutical Sciences, University of Strathclyde of UK from September 1991 until December 1992. Dr. Hang completed his Ph.D. in Pharmaceutical Analysis at China Pharmaceutical University from 1998 to 2002.

Dr. Hang isthe editorial board member for Journal of Pharmaceutical and Biomedical Analysis, Chinese Journal of New Drugs and Journal of Pharmaceutical Analysis( both Chinese and English), respectively.

1. Wang S, Kong X, Chen N, Hu P, Boucetta H, Hu Z, Xu X, Zhang P, Zhan X, Chang M, Cheng R, Wu W, Song M, Lu Y, Hang T. Hepatotoxic metabolites in Polygoni Multiflori Radix- Comparative toxicology in mice. Front Pharmacol. 2022 Oct 11;13:1007284. doi: 10.3389/fphar.2022.1007284.

2. Wu W, Cheng R, Boucetta H, Xu L, Pan JR, Song M, Lu YT, Hang TJ. Differences in Multicomponent Pharmacokinetics, Tissue Distribution, and Excretion of Tripterygium Glycosides Tablets in Normal and Adriamycin-Induced Nephrotic Syndrome Rat Models and Correlations With Efficacy and Hepatotoxicity. Front Pharmacol. 2022 Jun 9;13:910923. doi: 10.3389/fphar.2022.910923.

3. Han X, Cheng FJ, Di B, Xu H, Song M, Hang TJ, Lu YT.Identification and characterization of new impurities in zopiclone tablets by LC-QTOF-MS. J Pharm Biomed Anal. 2021 May 30;199:114056. doi: 10.1016/j.jpba.2021.114056.

4. Wu X, Yan R, Guan R, Du Y, Liu Y, Wu S, Zhu S, Song M, Hang T. Arsenic-Related Health Risk Assessment of Realgar-Containing NiuHuangJieDu Tablets in Healthy Volunteers Po Administration. Front Pharmacol. 2022 Jan 7;12:761801. doi: 10.3389/fphar.2021.761801.

5. Jiang J, Hu ZL, Boucetta H, Liu JM, Song M, Hang TJ, Lu YT. Identification of degradation products in flumazenil using LC-Q-TOF/MS and NMR: Degradation pathway elucidation. J Pharm Biomed Anal. 2022 Jun 5;215:114764. doi: 10.1016/j.jpba.2022.114764.

6. Lu YT, Qi WZ, Wang S, Song XN, Yang DY, Song M, Hang TJ. Toxicity and risk assessment of mercury exposures from cinnabar and Baizi Yangxin Pills based on pharmacokinetic and tissue distribution studies. J Ethnopharmacol. 2020 Mar 25;250:112489. doi: 10.1016/j.jep.2019.112489.

7. Lu YT, Guan R, Zheng JR, Hang TJ, Song M. Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies. J Pharm Biomed Anal. 2020 Apr 23;186:113322. doi:10.1016/j.jpba.2020. 113322.

8. Sun X, Xu X, Chen Y, Guan R, Cheng T, Wang Y, Jin R, Song M, Hang T. Danggui Buxue Decoction Sensitizes the Response of Non-Small-Cell Lung Cancer to Gemcitabine via Regulating Deoxycytidine Kinase and P-glycoprotein. Molecules. 2019 May 25;24(10):2011. doi: 10.3390/molecules24102011.

9. Wu X, Guan R, Liu Y, Wu S, Song M, Hang T.Comparative health risk assessment of realgar and NiuHuangJieDu tablets based on tissue arsenic levels after multiple oral administration to rats. J Ethnopharmacol. 2020 Mar 1;249:112370. doi: 10.1016/j.jep.2019.112370.

10. Wu X, Wu S, Liu Y, Guan R, Liang F, Song M, Hang T. Health risk assessment of arsenic in Realgar and NiuHuangJieDu Tablets based on pharmacokinetic study.J Trace Elem Med Biol. 2018 Jul;48:81-86. doi:10.1016/j.jtemb.2018.03.012.

Lu Y, Sun X, Song F, Wang L, Song M, Hang T. Impurity profiling of varenicline tartrate by LC-QTOF mass spectrometric techniques during drug development. J Pharm Biomed Anal. 2018 Jun 5;155:306-313. doi:10.1016/j.jpba.2018.03.055. 

(1) Polygoni Multiflori Radix Hepatotoxicity investigation through Comparative investigation.

(2) The Efficacy and potential toxicity evaluation of Tripterygium Glycosides Tablets.(NSFC30973931)

(3) Toxicity and risk assessment of mercury exposures from cinnabar and cinnabar containing TCMs such as Baizi Yangxin Pills based on pharmacokinetic and tissue distribution studies.(NSFC81473176)

(4) Health risk assessment of arsenic in Realgar and Realgar containing TCMs such as NiuHuangJieDu Tablets based on pharmacokinetic study.(NSFC81173648)

       (5) Impurity profiling of Chemical drugs and illegal drug abuse analysis by hyphenated techniques. (Key-NSFC2018YFC0807400)

1、2010Pharmaceutical Analysis class as a National bilingual Taught demonstration course of China1/Course director

2、2012Pharmaceutical Analysis text books (6Ed~9Ed, Beijing, People's Medical Publishing Hose,2006, 2011, 2016, 2022) was awarded as the China twelfth 5-year period national planned text book 1/Chief Editor

3、2015, 2022Pharmaceutical Analysis text books (7Ed~9Ed, Beijing, People's Medical Publishing Hose,2011, 2016, 2022) were awarded as the Provincial important text book for high education of Jiangsu1/Chief Editor

4、2018Advanced Pharmaceutical Analysis was awarded as the Provincial Excellent course for English taught foreign Master degree students in Jiangsu1/Course director

Dr. Hang has authored over 300 peer-reviewed publications, and worked as the chief editor for the China national planned text book of Pharmaceutical Analysis (7Ed~9Ed, Beijing, People's Medical Publishing Hose,2011, 2016, 2022) for the pharmaceutical sciences college studentsand several invited book chapters.