Hanzhihao

Research interests: Design and development of radiopharmaceuticals based on bioinformatics and their application in vivo. He has published more than 10 papers in J.ED.Chem, Anal.Chem, etc., 13 authorized patents (2 transferred), 3 software Copyrights, presided over 5 scientific research projects such as National Youth Fund, Provincial Youth Fund and school-enterprise cooperation, and won the second prize of Science and Technology of Jiangsu Province (4/7). At present, he serves as the leader of the radiation safety technology group of the school and the member of the nuclear education special Committee of the Jiangsu Nuclear Society. He has presided over the research topic of radiopharma, participated in the preparation of the national group standard of radiopharma operation, and has carried out cooperative research and development with more than ten nuclear drug industry units. Responsible for the teaching and research work of Nuclear Engineering Technology and medical equipment in our school, responsible for the maintenance of large equipment such as microSPECT/CT and gamma cameras in the isotope building, radiation safety management of the school's non-sealed radioactive material operation site (Class B and Class C areas), and teaching courses such as Fundamentals of Clinical Testing. Guided undergraduate students to win 3 awards in national and provincial discipline competitions.

(1) Han Zhihao^#; Li Yi^#; Wang Xin; Li Chang; Li Changsheng; Lin Qiao; Xu Enping; Tang Jinlong; Lai Maode; Ma Yi*; Gu Yueqing*; In Vivo Staging the Progression of Colitis and Associated Cancer by Concurrent Microimaging of Key Biomarkers, Analytical Chemistry, 2023, 95(27): 10298-10308. 

(2)Han Zhihao; Lian Chen; Ma Yuxuan; Zhang Congying; Liu Zicun; Tu Yuanbiao; Ma Yi; Gu Yueqing*; A frog-derived bionic peptide with discriminative inhibition of tumor based on integrin αvβ3 identification, Biomaterials Science, 2020, 8(1): 5920-5930. 

(3)Huang Wenjing; Wang Li; Zhang Hao; Han Zhihao*; Gu Yueqing*; Near-infrared targeted EGFR fluorescent probe for tumor imaging and diagnosis, Sensors and Actuators: B. Chemical, 2023, 393(15): 134102.

(4) Jiaxian Cai; Chen Lian; Zeyu Lu; Qian Shang; Li Wang; Zhihao Han* ; Yueqing Gu* ; FGF19-Based Mini Probe Targeting FGFR4 for Diagnosis and Surgical Navigation of Hepatocellular Carcinoma, Journal of Medicinal Chemistry, 2024.

(5) Xin Wang, Xianrui Yin, Keshuai Huang, Chang Li, Cheng Liu, Xin Chen, Qiao Lin, Siwen Li, Zhihai Han*, Yueqing Gu*; In vivo staging of colitis, adenoma and carcinoma in CRC progression by combination of H4R/DRD4-targeted fluorescent probes, European Journal of Medicinal Chemistry, 2024.

(6) Junbo Tang, Wenlong Zuo, Lizhen Guo, Zhihao Han, Chengfeng Yang, Benfeng Han, Lei Dai*, Xue Zhang* and Xin Zhou*. Synergistic pectin deconstruction is a prerequisite for mutualistic interactions between honeybee gut bacteria. Nature Communications, 2024(15): 6937.

(1) Atomic High-tech Co., LTD., Joint Laboratory, 8210110019, Radiopharmaceutical Innovation and Transformation Research (Nuclear molecular Probes targeting carcinoembryonic antigens), 2021-09 to 2025-09, 1 million, ongoing research, Host

(2) Key Laboratory of Nuclear Medicine, National Health Commission, Open project, KF202202, In Vivo Visualization of Carcinoembryonic antigen in the evolution of colorectal Cancer, 2023-01 to 2024-12, 50,000, in research, Host 

(1) Second Prize of Natural Science of Jiangsu Province in 2021

(2) First Prize of Basic Research of Jiangsu Biomedical Engineering Society in 2023