Jinliang

Jin Liang, Professor, Doctoral Supervisor, Jiangsu Province Distinguished Professor. Research focuses on the regulation and regeneration of pancreatic function, exploring the proliferation and differentiation patterns of pancreatic progenitor cells; Analyze the role and mechanism of non coding RNA in maintaining blood glucose homeostasis, and reveal new laws of glucose and lipid metabolism regulation and homeostasis maintenance. The research has received funding from provincial and ministerial level projects such as the 863 Program of the Ministry of Science and Technology (2015AA020314) and the National Natural Science Foundation of China (30701023, 31270985815706698207080182373925); The research results were published by the corresponding authors in journals such as Nat Commun (2023, 2021, 2020), PNAS (2020), Diabetes (2022), and Diabetologia (2020). Authorized over 10 invention patents.

① Fangfang Zhang, Dongshen Ma, Wanli zhao, Danwei Wang, Tingsheng Liu, Yue Liu, Yue Yang, Yuho ng Liu, Jinming Mu, Bingbing Li, Yanfeng Zhang, Yi Pan, Changying Guo, Hong Du, Ling Li, Xianghui Fu*, Zhengyu Cao*, Liang Jin*, Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion. Nature Communications, 2020, 11(1): 1822.

② Fangfang Zhang^#, Yue Yang^#, Xi Chen, Yue Liu, Qianxing Hu, Bin Huang, Yuhong Liu, Yi Pan, Yanfeng Zhang, Dechen Liu, Rui Liang, Guoqing Li, Qiong Wei*, Ling Li*, Liang Jin*, The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice. Nature Communications, 2021;12(1):3997.

③ Fangfang Zhang, Yuhong Liu, Danwei Wang, Tingsheng Liu, Yue Yang, Jiamin Guo, Yi Pan, Yanfeng Zhang, Hong Du, Ling Li, Liang Jin*, Obesity-induced reduced expression of lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation. Diabetologia, 2020, 63(4): 811-824. 

④  Yue Liu; Yue Yang; Chenying Xu; Jianxing Liu; Jiale Chen; Guoqing Li; Bin Huang; Yi Pan; Yanfeng Zhang; Qiong Wei; Stephen J. Pandol; Fangfang Zhang*; Ling Li*; Liang Jin*; Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity, Nature Communications, 2023, 14(1): 351.

⑤ Qianxing Hu^#, Jinming Mu^#, Yuhong Liu^#, Yue Yang, Yue Liu, Yi Pan, Yanfeng Zhang, Ling Li, Dechen Liu, Jianqiu Chen*, Fangfang Zhang*, Liang Jin*, Obesity-induced miR-455 upregulation promotes adaptive pancreatic β-cell proliferation through the CPEB1/CDKN1B pathway. Diabetes, 2022, 71(3): 394-411.

① National Natural Science Foundation project，Exosomal miR-455 derived from pancreatic islets mediates the crosstalk between beta cells and macrophages to regulate blood glucose homeostasis in obesity. 82373925，2024.01-2027.12，490000；

② National Natural Science Foundation project，The role and mechanism of miR-148a in the communication between adipose tissue and pancreatic islets. 82100858， 2022.01-2024.12，300000；

③ Jiangsu Province natural science Foundation project，Mechanistic study on the role of lnc-β Faar targeting Rab18 in maintaining lipid homeostasis and improving insulin resistance. BK20221520，2022.07-2025.06，100000；