Lihongmei

Dr Li is an associate professor of Medicinal Chemistry. She graduated from China Pharmaceutical University, majoring in Pharmacy. In 2017, she received her Doctor of Science degree in Pharmaceutical Chemistry. In the same year, she stayed at the university and engaged in postdoctoral research. She was promoted to associate researcher in 2021. Her main research direction is pharmaceutical chemistry, and she conducts small molecule innovative drug research through the intersection of pharmaceutical chemistry, bioinformatics and pharmacology. She has published her research in pharmaceutical journals with long-standing reputation such as SCI ADV, JMC, and EJMC.

1. Cong Wang, Jiawei Xia, Yan Lei, Rui Lu, Mingliang Zhang, He Lv, Qianqian Hong,Tao Lu*, Yadong Chen*, Hongmei Li * Synthesis and biological evaluation of 7H-pyrrolo [2,3-d] pyrimidine derivatives as potential p21-activated kinase 4 (PAK4) inhibitors[J], Bioorg. Med. Chem. 60 (2022) 116700

2. Zhijie Wang, Jiongheng Cai, Jiwei Ren, Yun Chen, Yingli Wu, Jie Cheng, Kun Jia,Fei Huang, Zitian Cheng, Tiancheng Sheng, Shiyu Song, Hao Heng, Yifan Zhu, Weifang Tang, Hongmei Li,* Tao Lu,* Yadong Chen,* and Shuai Lu* Discovery of a Potent FLT3 Inhibitor (LT-850-166) with the Capacity of Overcoming a Variety of FLT3 Mutations[J], J. Med. Chem. 2021, 64, 14664−14701

3. Hongmei Li^#, Yanran Bi^#, Yang Li^#, Rong Fu^#, Wencong Lv, Nan Jiang, Ying Xu, Boxue Ren, Yadong Chen, Hui Xie, Shui Wang, Tao Lu*, Zhaoqiu Wu*,A potent CBP/p300-Snail interaction inhibitor suppresses tumor growth and metastasis in wild-type p53-expressing cancer [J], Sci Adv, 2020, 6, 1-17

4.Junyu Xu^#, Hongmei Li^#, Xinren Wang, Jianhang Huang, Shuwen Li, Chenhe Liu, Ruinan Dong, Gaoyuan Zhu, Chunqi Duan, Fei Jiang, Yanmin Zhang, Yuqin Zhu, Tianyi Zhang, Yadong Chen*, Weifang Tang*, Tao Lu*, Discovery of coumarin derivatives as potent and selective cyclin- dependent kinase 9 (CDK9) inhibitors with high antitumour activity[J], Eur J Med Chem, 2020, 112424-112448

5.Mingliang Zhang, Xiaobao Fang, Cong Wang, Yi Hua,Chen Huang, Meng Wang, Lu Zhu, Zixu Wang, Yuhan Gao, Tianyi Zhang, Haichun Liu, Yanmin Zhang, Shuai Lu, Tao Lu*, Yadong Chen*, Hongmei Li* Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities[J], Eur J Med Chem, 2020, 203: 112517

Drug discovery and development, Study on the research of small molecule innovative drugs targeting on transcription factor

Jiangsu Province Medical Science and Technology Award in 2019 (ranking fifth).