Lilimin

Dr. Li graduated from Nanjing University in 2012 and is currently an associate professor and doctoral supervisor at the School of Life Science and Technology, China Pharmaceutical University; Dr. Li is currently a young member of the Kidney Disease Professional Committee of the Chinese Society of Pathophysiology and a member of the Basic Immunology Professional Committee of the Jiangsu Society of Immunology; She has been selected for the Jiangsu Excellent Youth Fund and the Six Talent Peaks talent project in Jiangsu Province. Dr. Li Limin has been engaged in the studies of pathogenesis of kidney diseases and the development of kidney disease diagnosis services and products. So far, she has published more than 40 papers in journals such as Nature Communication, Nucleic Acid Res, J AM SOC NEPHROL, Cell Res, J Immunol, and Cancer Res, with a maximum citation of over 400 times and more than 10 patent applications.

1. Qian B, Lu R, Mao S, Chen Y, Yang M, Zhang W, Zhang M, Zhu D, Liu Z, Zen K*, Li L*. Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses. Cell Rep. 2024 May 28;43(5):114249.

2. Zhu Y#, Zhang M#, Wang W, Qu S, Liu M, Rong W, Yang W, Liang H, Zeng C, Zhu X, Li L*, Liu Z*, Zen K*. Polynucleotide phosphorylase protects against renal tubular injury via blocking mt-dsRNA-PKR-eIF2α axis. Nat Commun. 2023, 14(1).

3. Wang H, Lv D, Jiang S, Hou Q, Zhang L, Li S, Zhu X, Xu X, Wen J, Zeng C, Zhang M, Yang F, Chen Z, Zheng C, Li J, Zen K, Liu Z*, Li L*. Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction. Cell Death Dis, 2022, 13(3).

4. Li L#, Liu Y#, Li S#, Yang Y, Zeng C, Rong W, Liang H, Zhang M, Zhu X, Kidder K, Liu Y, Liu Z, Zen K. Signal regulatory protein α protects podocytes through promoting autophagic activity. JCI Insight. 2019 Mar 19;5.

5. Jin F#, Yang R#, Wei Y#, Wang D, Zhu Y, Wang X, Lu Y, Wang Y*, Zen K*, Li L*. HIF-1α-induced miR-23a∼27a∼24 cluster promotes colorectal cancer progression via reprogramming metabolism. Cancer Lett. 2019 Jan;440-441:211-222. 

6. Wang D#, Sun X#, Wei Y#, Liang H, Yuan M, Jin F, Chen X, Liu Y, Zhang CY*, Li L*, Zen K*. Nuclear miR-122 directly regulates the biogenesis of cell survival oncomiR miR-21 at the posttranscriptional level. Nucleic Acids Res. 2018 Feb 28;46(4):2012-2029. 

1. Role of proximal renal tubular epithelial cell exosomal mitochondrial double-strand RNA in mediating podocyte injury during AKI-CKD progression;

2. The role and mechanism of signaling regulatory protein α mediated podocyte antigen presentation in podocyte injury;

3. Development of diagnostic technology for diabetes nephropathy based on urinary vesicular protein markers.