Lumeiling

Dr Meiling Lu is an associate professor and master's supervisor who received her Ph.D. in 2012 through a joint program between China Pharmaceutical University and the University of Texas Medical Branch. Her research is at the forefront of multidisciplinary science, combining X-ray crystallography and cryo-electron microscopy to explore several key areas:

(1) CRISPR-Cas Systems: She investigates the structure and mechanism of novel CRISPR-Cas effector complexes, with a focus on their potential applications in gene editing across both prokaryotic and eukaryotic cells.

(2) Bacterial Defense Mechanisms: Her work includes studying various bacterial defense systems and their interactions, aiming to uncover new antibacterial strategies.

(3) Drug Target Proteins: She also focuses on the mechanism of drug-target proteins and their inhibitors using protein crystal X-ray diffraction.

Professor Lu's research contributes significantly to the understanding of complex biological systems and the development of innovative therapeutic strategies.

1. Meiling Lu*, Chenlin Yu, Yuwen Zhang, Wenjun Ju, Zhi Ye, et al. Structure and genome editing of type I-B CRISPR-Cas. Nat Commun. 2024, 15:4126.

2. Ling Zhao, Yuncong Xu, Manting Chen, Lingrui Wu, Meng Li, Yuanyuan Lu, Meiling Lu*, Yijun Chen*, Xuri Wu*. Design of a chimeric glycosyltransferase OleD for the site-specific O monoglycosylation of 3-hydroxypyridine in nosiheptide. Microb Biotechnol. 2023, 16(10):1971-1984.

3. Kuojun Zhang, Tianyu Wang, Maotian Li, Mu Liu, He Tang, Lin Wang, Ke Ye, Jiamei Yang, Sheng Jiang, Yibei Xiao, Youhua Xie, Meiling Lu*, Xiangyu Zhang*. Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 M). Eur J Med Chem. 2023, 257:115487.

4. Zhenyuan Si, Yang Cai, Lang Zhao, Lu Han, Feng Wang, Xiaobing Yang, Xiangdong Gao, Meiling Lu*, Wei Liu*. Structure and function characterization of the Alpha-L-arabinofuranosidase from the white-rot fungus Trametes hirsuta. Appl Microbiol Biotechnol. 2023, 107(12):3967-3981.

5. Xiaoke Wang, Qinling Yuan, Wenxuan Zhang, Suyu Ji, Yang Lv, Kejing Ren, Meiling Lu*, Yibei Xiao*. Sequence specific integration by the family 1 casposase from Candidatus Nitrosopumilus koreensis AR1. Nucleic Acids Res. 2021, 49(17):9938-9952.

6. Chengchang Zhang^#, Meiling Lu^#, Lin Lin, Zhangjian Huang, Rongguang Zhang, Xuri Wu, Yijun Chen. Riboflavin Is Directly Involved in N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases. Chembiochem. 2020, 21(16):2297-2305.

7. Xiao-Kun Gu, Xin-Rui Li, Mei-Ling Lu*, Hui Xu*. Lithium promotes proliferation and suppresses migration of Schwann cells. Neural Regen Res. 2020, 15(10):1955-1961.

1. “Pathomechanism-Driven Drug Screening and Development for Rare Childhood Diseases” SQ2023YFC2700057, National Key Research and Development Program of China, Sub-project Principal Investigator.

2. “Exploration, Development, and Mechanistic Analysis of Novel Gene Editing Systems” SQ2023YFC3400181, National Key Research and Development Program of China, Sub-project Principal Investigator.

1. “Discovery, Catalytic Mechanism, and Pharmaceutical Biosynthesis Applications of diketoreductase”. 2019 Jiangsu Province Science and Technology Award, Second Prize (3/6).