Liuqinghe

Qinghe was born in Anyang, China. He graduated from Zhengzhou University with a bachelor's degree under the supervisor of Prof. Gang Li in 2012, and Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences with a doctor degree under the supervisor of Prof. Jinbo Hu in 2017. From 2018 to 2023, he conducted postdoctoral research at Boston College under the supervisor of Prof. Amir H. Hoveyda. After the journey in United States, Qinghe joined China Pharmaceutical University in 2023. Qinghe’s group mainly focus on synthetic chemical engineering.

1. Synthesis of Z-gem-Cl,CF3 -Substituted Alkenes by Stereoselective Cross-Metathesis and the Role of Disubstituted Mo Alkylidenes.Liu, Q.; Qin, C.; Wan, J.; Bin, K.; Sui, X.; Kobayashi, H.; Zahedian, H.; Liu, P.; Hoveyda, A. H.J. Am. Chem. Soc. 2024, accepted

2. Taking Olefin Metathesis to the Limit: Stereocontrolled Synthesis of Trisubstituted Alkenes. Hoveyda, A. H.*; Qin, C.; Sui, X. Z.; Liu, Q.; Li, X.; Nikbakht, A.Acc. Chem. Res. 2023, 56, 2426.

3. Catalytic Cross-Metathesis Reactions that Afford E- and Z-Trisubstituted Alkenyl Bromides. Scope, Applications, Mechanistic Insights.Koengeter, T.; Qin, C.; Mai, B. K.; Liu, Q.; Mu, Y.; Liu, P.; Hoveyda, A. H.*J. Am. Chem. Soc. 2023, 145, 3774-3785. (IF: 16.3)

4. Stereodefined alkenes with a fluoro-chloro terminus as a uniquely enabling compound class. Liu, Q.; Mu, Y.; Koengeter, T.; Schrock, R.; Hoveyda, A. H.*Nat. Chem 2022, 14, 463. (IF: 24.3)

5. Difluoromethyl 2-pyridyl sulfoximine: a stereoselective nucleophilic reagent for difluoro(aminosulfinyl)methylation and difluoro(aminosulfonyl)methylation. Liu, Q.; Ni, C.; Wang, Q.; Meng, D.; Hu, J.*CCS Chem 2022, 4, 3648.

6. Commercially available organofluorine compounds as convenient launching points for stereocontrolled synthesis of more complex derivatives. Paioti, P. H. S.; Fager, D.; Xu, S.; Liu, Q.; Hoveyda, A. H.*Angew. Chem. Int. Ed. 2022, accepted. (IF: 16.8) (doi.org/10.1002/anie.202208742)

7. From C1 to C3: copper-catalyzed gem-bis (trifluoromethyl)olefination of α-diazo esters with TMSCF3. Wang, Q.; Ni, C.; Hu, M.; Xie, Q.; Liu, Q.; Pan, S.; Hu, J.*Angew. Chem. Int. Ed. 2020, 59, 8507. (IF: 16.8)

8. Catalytic enantioselective synthesis of allylic boronates bearing a trisubstituted alkenyl fluoride and related derivatives.

Akiyama, S.; Kubota, K.; Mikus, M. S.; Paioti, P. H. S.; Romiti, F.; Liu, Q.; Zhou, Y.; Hoveyda, A. H.*; Ito, H.*Angew. Chem. Int. Ed. 2019, 58, 11998. (IF: 16.8)

9. Stereoselective carbonyl olefination with fluorosulfoximines: facile access to Z or E terminal monofluoroalkenes.Liu, Q.; Shen, X.; Ni, C.; Hu, J.*Angew. Chem. Int. Ed. 2017, 56, 619. (IF: 16.8)

10. China's flourishing synthetic organofluorine chemistry: innovations in the new millennium.Liu, Q. ; Ni, C. ; Hu, J.*Natl. Sci. Rev. 2017, 4, 303. (IF: 23.2)

1) use of organic fluorine-containing active intermediates for the synthesis of fluorine-containing drug molecules and fluorine-containing functional molecules; 

2) chemical space modification and evaluation of natural drug active molecules; 

3) Precise synthesis of F-18 radioactive probes and their biological activity evaluation.

1. SIOC Postdoctoral Fellowship

2. Yu Wang Doctoral Scholarship

3. Leading Cadres Award of Shanghai Technical System

4. Excellent Graduate Students of Shanghai