Liuyi

Professor Liu is currently working in the Department of Biomedical Engineering and Diagnostic Pharmacy, School of Engineering, China Pharmaceutical University. Prof. Liu worked as a postdoctoral fellow in molecular imaging in Xiaoyuan Chen's group at the National Institutes of Health (NIH) and received his Ph. D. in Inorganic Chemistry from Fudan University. Prof. Liu specializes in the application of small molecule probes for in vitro diagnosis and in vivo monitoring of pathological target molecules, with a focus on the development of responsive organic functional materials for early diagnosis and precision treatment of diseases.

Research Interests:

1. Small molecule probes for in vitro diagnosis and in vivo monitoring of pathological target molecules.

2. Responsive organic functional materials for early diagnosis and precise treatment of diseases.

1. “Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy” – Published in Acta Pharmaceutica Sinica B, 2024.

2. “Near Infrared Light-Activatable Platelet-Mimicking NIR-II NO Nano-Prodrug for Precise Atherosclerosis Theranostics” – Published in Advanced Science, 2024.

3. “Near-infrared fluorescence probes for monitoring and diagnosing nephron-urological diseases” – Published in  Coordination Chemistry Reviews, 2023.

4. “Frequency upconversion luminescence: New frontiers in bioapplications” – Published in Coordination Chemistry Reviews, 2023.

5. “Rational Design of pH-Activated Upconversion Luminescent Nanoprobes for Bioimaging of Tumor Acidic Microenvironment and the Enhancement of Photothermal Therapy – Published in Acta Biomaterialia, 2023.

6. “Platelet-Mimicking Therapeutic System for Noninvasive Mitigation of the Progression of Atherosclerotic Plaques” – Published in Advanced Science, 2021.

7. “Nitroso-Caged Upconversion Luminescent Prodrug: Near Infrared Light-Activatable NO Nano-Donor for Gas Therapy” – Published in Chemical Engineering Journal, 2021.

8. “γ-Glutamyl transpeptidase-activatable near-infrared nanoassembly for tumor fluorescence imaging-guided photothermal therapy” – Published in Theranostics, 2021.

9. “Ratiometric Photoacoustic Molecular Imaging for Methylmercury Detection in Zebrafish” – Published in Advanced Materials, 2017.

10. “Near-Infrared Upconversion Chemodosimeter for in vivo Detection of Cu²⁺ in Wilson Disease” – Published in Advanced Materials, 2016.

11. “A Cyanine-Modified Nnaosystem for in vivo Upconversion Luminescence Bioimaging of Methylmercury” – Published in Journal of the American Chemical Society, 2013.

Responsive NO nanoprodrugs for optical imaging guiding gas therapy