Luyuting

Metallomics, Lipidomics, Assessment of drug quality and safety, Study on the material basis and mechanisms of TCMs

1、Educational Experience

2017    Ph.D., Pharmaceutical Analysis, China Pharmaceutical University

2012    B.S., Pharmaceutical Engineering, China Pharmaceutical University

2、Working Experience

2022-       Associate Research Fellow of Pharmaceutical Analysis, China Pharmaceutical University

2020-2021   Lecturer of Pharmaceutical Analysis, China Pharmaceutical University

2017-2019   Postdoctoral of Traditional Chinese Pharmacy, China Pharmaceutical University

1. Wu W.; Cheng R.; Boucetta H.; Xu L.; Pan J.R.; Song M.; Lu, Y.T.*; Hang, T.J.*. Differences in Multicomponent Pharmacokinetics, Tissue Distribution, and Excretion of Tripterygium Glycosides Tablets in Normal and Adriamycin-Induced Nephrotic Syndrome Rat Models and Correlations with Efficacy and Hepatotoxicity. Front. Pharmacol. 2022, 13, 910923. (IF: 5.988)

2. Jiang, J.; Hu, Z.L.; Boucetta, H.; Liu, J.M.; Song, M.; Hang, T.J.*; Lu, Y.T.* Identification of degradation products in flumazenil using LC-Q-TOF/MS and NMR: Degradation pathway elucidation.  J. Pharm. Biomed. Anal. 2022, 12;215:114764. (IF: 3.571)

3. Xu, L.; Wang, Y.; Wu, D.F.; Sun, F.M.; Di, B.; Xu, H.; Song, M.; Lu, Y.T.*; Hang, T.J.* Identification and monitoring of fentanyls-related substances in east China sewage water samples by LC-MS for drug enforcement. Sci Total Environ. 2021, 797:149109. (IF:7.963)

4. Han, X.; Cheng, F.J.; Di, B.; Xu, H.; Song, M.; Hang, T.J.*; Lu, Y.T.* Identification and characterization of new impurities in zopiclone tablets by LC-QTOF-MS. J. Pharm. Biomed. Anal. 2021, 199:114056. (IF: 3.935)

5. Lu, Y.T.; Hu, Z.L.; Shao, F.X.; Song, M. Hang, T.J.* Simultaneous determination of tazarotene, clindamycin phosphate and their active metabolites in Bama mini-pig skin by LC-MS/MS: Application to the development of a tazarotene/clindamycin phosphate cream techniques. J. Chromatogr. B 2021, 1162:122455. (IF: 3.205)

6. Lu, Y.T.; Guan, R.; Zheng, J.R.; Hang, T.J.*; Song, M.* Determination of clobetasol propionate, tazarotene and tazarotenic acid in Bama mini-pig skin by UPLC-MS/MS: Application to pharmacokinetic and drug-drug interaction studies. J. Pharm. Biomed. Anal. 2020, 186, 113322. (IF: 3.209)

7. Lu, Y.T.; Qi, W.Z.; Wang, S.; Song, X.N.; Yang, D.Y.; Song, M.; Hang, T.J.* Toxicity and risk assessment of mercury exposures from cinnabar and Baizi Yangxin Pills based on pharmacokinetic and tissue distribution studies. J Ethnopharmacol. 2020, 250, 112489. (IF: 4.360)

8. Lu, Y.T.; Chen, Y.F.; Qi, W.Z.; Song, M.*; Hang, T.J.* Separation and identification of process-related substances and degradation products in mycophenolate mofetil by LC-QTOF mass spectrometric method. J. Sep. Sci. 2019, 42(16):2650-2659. (IF: 2.878)

9. Lu, Y.T.; Sun, X.Y.; Song, F.; Wang, L.; Song, M.; Hang, T.J.* Impurity profiling of varenicline tartrate by LC-QTOF mass spectrometric techniques during drug development. J. Pharm. Biomed. Anal. 2018, 155: 306-313. (IF: 2.983)

Lu, Y.T.; Yang, D.Y.; Song, X.N.; Wang, S.; Song, M.; Hang, T.J.* Bioaccessibility and health risk assessment of mercury in cinnabar containing Traditional Chinese Medicines. J. Trace Elem. Med. Bio. 2017, 44: 17-25. (IF: 3.755) 

1. Study of the mechanisms of cinnabar-induced central neurotoxicity based on the Metallomics of mercury (Grant Number: 81903911), supported by National Natural Science Foundation of China, 2020-2022.

2. Study of the central neurotoxicity of Cinnabaris based on the Metallomics (Grant Number: BK20190556), supported by Natural Science Foundation of Jiangsu Province, 2019- .

3. Study on the toxicity and safety of Cinnabaris-containing TCM Baizi Yangxin Pill based on the mercury speciation analysis (Grant Number: 2017M621885), supported by China Postdoctoral Science Foundation, 2017-2020.