Lizhen

Professor Zhen Li is a doctoral supervisor and a Xingyao Leading Scholar at China Pharmaceutical University. He obtained his Ph.D. in 2020 from Yangzhou University under the mentorship of Professor Weiliang Duan. Following this, he pursued postdoctoral research at Scripps Research in the United States under the guidance of Professor Jin-Quan Yu. In 2024, he joined China Pharmaceutical University, where he is currently a faculty member in the Department of Pharmaceutical and Environmental Engineering at the School of Engineering. His research primarily focuses on green catalytic reactions in C-H bond activation and asymmetric synthesis. Professor Li has published several papers as the first author in prestigious international journals such as Science, JACS, and Angew. Chem. Int. Ed.

1. Li, Z.^#; Wang, Z.^#; Chekshin, N.; Qian, S.; Qiao, J. X.; Cheng, P. T.; Yeung, K.-S.; Ewing, W. R.; Yu, J.-Q.* A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen. Science 2021, 372, 1452.

2. Li, Z.^#; Park, H. S.^#; Qiao, J. X.; Yeung, K.-S.; Ewing, W. R.; Yu, J.-Q.* Ligand-enabled C−H hydroxylation with aqueous H₂O₂ at room temperature. J. Am. Chem. Soc. 2022, 144, 18109.

3. Li, Z.; Yu, J.-Q.* Ligand-enabled-C(sp³)−H hydroxylation of free amines with aqueous hydrogen peroxide. J. Am. Chem. Soc. 2023, 145, 25948.

4. Li, Z.; Lin, Z.-Q.; Yan, C.-G.; Duan, W.-L.* Pd-catalyzed asymmetric C−H bond activation for the synthesis of Pstereogenic dibenzophospholes. Organometallics 2019, 38, 3916.

5. Li, Z.; Duan, W.-L.* Palladium-catalyzed C−H alkenylation of arenes with alkynes: stereoselective synthesis of vinyl chlorides via a 1,4-chlorine migration. Angew. Chem. Int. Ed. 2018, 57, 16041.

1. Late-Stage Modification of Drug Molecules

Innovate efficient chemical synthesis methods to precisely modify complex drug molecules, enhancing their biological activity.

2. Large-Scale Drug Manufacturing

Develop environmentally friendly and cost-efficient chemical processes for drug synthesis to significantly lower production costs.