Sunhaopeng

Sun Haopeng is a professor and doctoral supervisor. His research mainly focuses on the discovery and optimization of bioactive molecules related to neurodegenerative diseases, central tumors, and metabolic disorder-related diseases. He has published over 180 SCI papers in journals such asJ. Am. Chem. Soc., J. Med. Chem., Acta Pharm. Sin. B, Angew. Chem. Int. Edit., and Med. Res. Rev., with a total of 5,900 citations and an H-index of 42. He has obtained 25 authorized national invention patents and achieved the enterprise transformation of 3 patented technologies. He has been selected as a national high-level young talent, a member of the 333 High-level Talent Training Project in Jiangsu Province, an excellent young backbone teacher in the Qinglan Project, and a recipient of the Chinese Pharmaceutical Association-Servier Youth Medicinal Chemistry Award. He has presided over or participated in more than ten projects, including those funded by the National Natural Science Foundation, Jiangsu Provincial Natural Science Foundation, Ministry of Education, and Jiangsu Provincial Engineering Center Construction. Students in his research group have received numerous graduate national scholarships, president's scholarships, key cultivation for excellent thesis, and scholarships at various levels.

1. Wang, L.; Sun, T. Y.; Zhen, T. F.; Li, W.; Yang, H. J.; Wang, S. Y.; Feng, F. ^*; Chen, Y. ^*; Sun, H. P. ^* Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer's Disease. J. Med. Chem. 2024, 67(8), 6793-6809. 

2. He, S. Y.; Chu, X. L.; Wu, Y. J.; Jiang, J. H.; Fang, P. F.; Chen, Y. T.; Liu, Y.; Qiu, Z.X.; Xiao, Y. B.; Li, Z. Y.; Pan, D.; Zhang, Q.; Xie, H. F.; Xing, S. S.; Feng, F.; Liu, W. Y.; Guo, Q. L.; Zhao, L.; Yang, P.; Sun, H. P. ^* Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment. J. Med. Chem. 2023, 66(14), 9537-9560. 

3. Du, C. X.¹; Wang, L.¹; Guan, Q. W.; Yang, H. Y.; Chen, T. K.; Liu, Y. J.; Li, Q. H.; Lyu, W. P.; Lu, X.; Chen, Y.; Liu, Y.; Liu, H.; Feng, F.; Liu, W. Y.; Liu, Z. L.; Li, W. ^*; Chen, Y. ^*; Sun, H. P. ^* N-benzyl Benzamide Derivatives as Selective Sub-nanomolar Butyrylcholinesterase Inhibitors for Alzheimer’s Disease. J. Med. Chem. 2022, 65(16), 11365-11387.

4. Li, Q.; Chen, Y.; Xing, S. S.; Liao, Q. H.; Xiong, B. C.; Wang, Y. Y.; Lu, W. X.; He, S. Y.; Feng, F.; Liu, W. Y. ^*; Chen, Y. ^*; Sun, H. P. ^* Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection. J. Med. Chem. 2021, 64(10), 6856-6876.

5. Li, Q.; Xing, S. S.; Chen, Y.; Liao, Q. H.; Xiong, B. C.; He, S. Y.; Lu, W. X.; Liu, Y.; Yang, H. Y.; Li, Q. H.; Feng, F.; Liu, W. Y.; Chen, Y. ^*; Sun, H. P. ^* Discovery and biological evaluation of a novel highly potent selective butyrylcholinsterase inhibitor. J. Med. Chem. 2020, 63(17) 10030-10044. 

6. Tang, X. T.¹; Zhou, Y. E.¹; Wang, Y. J.; Lin, Y. T.; Pan, S. H.; Che, Q. W.; Sang, J. P.; Gao, Z. M.; Zhang, W. T.; Wang, Y. Y.;  Li, G. L.; Gao, L. W.; Wang, Z. M.; Yang, X. D.; Liu, A.; Wang, S. Y.; Yu, B.; Xu, P.; Wang, Z.; Yang, P.; Xie, W. J.; Sun, H. P. ^*; Li, W. ^* Direct Synthesis of α- and β-2’-Deoxynucleosides with Stereodirecting Phosphine Oxide via Remote Participation. J. Am. Chem. Soc. 2024, 146(12), 8768–8779.

7. Xing, S. S.; Li, Q.; Xiong, B. C.; Chen, Y.; Feng. F.; Liu, W. Y.; Sun, H. P. ^* Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer’s disease and fat metabolism. Med. Res. Rev. 2021, 41, 858-901.

8. Zhu, J.; Mo, J.; Lin, H. Z.; Chen, Y.; Sun, H. P. ^* The recent progress of isoxazole in medicinal chemistry. Bioorg. Med. Chem. 2018, 26(12), 3065-3075. DOI: 10.1016/j.bmc.2018.05.013. (WOS highly cited paper, 257 citations)

9. Wang, Y.; Jiang, X. Y.; Feng, F.; Liu, W. Y. ^*; Sun, H. P. ^* Degradation of proteins by PROTACs and other strategies, Acta Pharm. Sin. B 2020, 10, 207-238. (WOS highly cited paper, 205 citations)

10. Li, Q.; Yang, H. Y.; Chen, Y.; Sun, H. P. ^* Recent Progress in the Identification of Selective Butyrylcholinesterase Inhibitors for Alzheimer's Disease. Eur. J. Med. Chem. 2017, 132, 294-309. (WOS highly cited paper, 247 citations)

(1) Develop efficient and highly selective inhibitors around BChE and explore new strategies for treating AD. This series of work has published multiple papers in the top medicinal chemistry journals J. Med. Chem. and Eur. J. Med. Chem. Many types of highly selective BChE inhibitors have been discovered, and they are among the most active and selective BChE inhibitors that have been publicly reported. In addition, based on this, a new molecular probe was successfully designed to explore the biological function of BChE. The relevant work was published as a cover paper in the journal Chin. J. Chem.

(2) Design active small molecules targeting aldo-ketoreductase 1C (AKR1C) in order to treat primary liver cancer (HCC) and castration-resistant prostate cancer (CRPC), and to explore a new way to solve the problem of multidrug resistance. Relevant research has been funded by key projects of the National Natural Science Foundation and general projects of the Jiangsu Provincial Natural Science Foundation. Three types of new compounds with inhibitory activity reaching nanomolar levels and good AKR1C3 selectivity have been discovered. Relevant work has been published in journals such as J. Med. Chem., ACS Med. Chem. Lett., etc., and has applied for PCT patents and obtained national invention patents.

(3) Carry out research work around single-molecule multi-target ligands in order to solve the shortcomings of single-target drugs in the treatment of systemic diseases, and propose and explore a variety of multi-target strategies for the treatment of AD. In the past five years, more than 20 papers about the related work have been published in ACS Med. Chem. Lett. (cover article), Eur. J. Med. Chem., Bioorg. Chem., J. Enzym. Inhib. Med. Ch., etc., and six national invention patents have been applied.

(1) In 2016, second prize of National Science and Technology Progress Award, ranking sixth

(2) In 2015, first prize of Jiangsu Provincial Natural Science Award, ranking fifth

(3) In 2015, first prize of the National Ministry of Education, ranking fifth

(4) In 2015, 18th Chinese Pharmaceutical Association-Servier Youth Medicinal Chemistry Award, ranking first

Pharmaceutical Research Paper Writing