Wangchen

Through integrating comprehensive technology of molecular cell biology, immunology and disease animal model, Dr. Wang’s research mainly focused on identification and characterization of diverse key regulators playing pivotal roles in regulating early innate immune response as well as delineating the underlying molecular regulatory mechanism of innate immune that is associated with acute inflammation. His research especially focused on exploring and characterizing the roles of ubiquitin and ubiquitin-like modification (Ub, SUMO, ISG15, NEED8) in regulating cGAS-STING signaling pathway. Based on the identified key components of innate immune system, Dr. Wang has been working on lead compounds discovery by using the combination of computational approach and comprehensive natural small molecule compound library screening.

1. Mingyu Pan#, Tongyu Hu#, Jiao Lyu#, Yue Yin, Jing Sun, Quanyi Wang*, Lingxiao Xu*, Haiyang Hu*, Chen Wang*(2023). CSNK1A1/CK1α suppresses autoimmunity by restraining the CGAS-STING1 signaling. Autophagy. DOI: 10.1080/15548627.2023.2256135

2. Ze Hong# Saihua Chen#, Jing Sun#, Dan Cheng, Hanli Guo, Jiahao Mei, Xiang Zhang, Munire Maimaiti, Haiping Hao, Peng Cao, Haiyang Hu*, Chen Wang*（2023）. STING signaling in islet macrophages impairs insulin secretion in obesity. SCIENCE CHINA Life Sciences. https://doi.org/10.1007/s11427-022-2371-9

3. Mingyu Pan*, Yue Yin*, Tongyu Hu*, Xinxia Wang, Tian Jia, Jing Sun, Quanyi Wang, Wei Meng, Juanjuan Zhu, Chunsun Dai#, Haiyang Hu#, and Chen Wang# (2022): UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation. Autophagy. DOI: 10.1080/15548627.2022.2076192

4. Ze Hong#, Jiahao Mei#, Chenhui Li#, Guohui Bai, Munire Maimaiti, Haiyang Hu, Wenying Yu, Li Sun, Lele Zhange, Dan Cheng, Yixian Liao, Senlin Li, Yanping You, Hongbin Sun, Jing Huang, Xing Liu, Judy Lieberman*, and Chen Wang*（2021）：STING inhibitors target the cyclic dinucleotide binding pocket. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2105465118.

5. Chenhui Li# , Lele Zhang# , Dong Qian# , Mingxing Cheng, Haiyang Hu , Ze Hong, Ye Cui, Huansha Yu, Quanyi Wang, Juanjuan Zhu, Wei Meng, Jin-Fu Xu, Yi Sun*, Peng Zhang*, Chen Wang*(2021): RNF111-facilitated neddylation potentiates cGAS-mediated antiviral innate immune response. PLOS Pathogens. doi: 10.1371/journal.ppat.1009401

6. Shufang Cui#, Qiuya Yu#, Lei Chu, Ye Cui, Ming Ding, Quanyi Wang, Hongyun Wang, Yu Chen, Xing Liu*, Chen Wang* (2020): Nuclear cGAS Functions Non-Canonically to Enhance Antiviral Immunity via recruiting Methyltransferase Prmt5. Cell Reports. doi.org/10.1016/j.celrep.2020.108490

7. Mingyu Pan, Yue Yin, Xinxia Wang, Quanyi Wang Lele Zhang, Haiyang Hu*, Chen Wang* (2020): Mice deficient in UXT exhibit retinitis pigmentosa-like features via aberrant autophagy activation. Autophagy. doi.org/10.1080/15548627.2020.1796015

8. Lele Zhang#, Ning Wei#, Ye Cui, Ze Hong, Xing Liu, Qiang Wang, Senlin Li, Heng Liu, Huansha Yu, Yanni Cai, Quanyi Wang, Juanjuan Zhu, Wei Meng, Zhengjun Chen* and Chen Wang* (2018): The de-ubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway. PLOS Pathogens. Vol 14(11): e1007435. doi: 10.1371/journal.ppat.1007435.

9. Senlin Li#, Ze Hong#, Zhe Wang#, Fei Li, Jiahao Mei, Lulu Huang, Xiwen Lou, Simeng Zhao, Lihua Song, Wei Chen, Qiang Wang, Huimin Xu, Guangzhi Zeng, Heng Liu, Yanni Cai, Huansha Yu, Quanyi Wang, Juanjuan Zhu, Xing Liu*, Ninghua Tan*, Chen Wang* (2018): The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Reports. doi: 10.1016/j.celrep.2018.11.097. 

A functional and mechanistic study on the negative regulation of cGAS-STING signaling by inducing autophagy (No.82171751)

Development of humanized animal models of major infectious diseases based on new targets (No.2021YFF0702003)