Wanghang

Specializing in biochemistry and molecular biology, the research primarily focuses on elucidating the structure and function of biosynthetic enzymes and their catalytic mechanisms. Notable achievements include detailed structural analyses of various key biosynthetic enzymes, aimed at understanding their catalytic processes. A significant contribution involves the recombinant expression and characterization of triple-helical collagen, which advances its potential applications in regenerative medicine and tissue engineering. Furthermore, efforts in enzyme engineering are directed towards optimizing enzyme structures and functions to enhance their catalytic efficiency, stability, and specificity. These studies not only deepen the understanding of enzyme catalysis but also provide a strong foundation for developing innovative biocatalysts and therapeutic agents.

(1) Structural and Computational Insights into the Noncanonical Aromatization in Fungal Polyketide Biosynthesis; ACS Catal. 2024

(2) Structural insights into the substrate specificity and activity of a novel mannose 2-epimerase from Runella slithyformis, Acta Crystallographica Section D Structural Biology, 2023

(3) Extraction and characterization of polysaccharide from fermented mycelia of Coriolus versicolor and its efficacy for treating nonalcoholic fatty liver disease; Int J Biol Macromol, 2023

(4) Molecular Basis for the Biosynthesis of an Unusual Chain-Fused Polyketide Gregatin A, Journal of the American Chemical Society, 2020

Crystal structures clarify cofactor binding of plant tyrosine decarboxylase, Biochemical and Biophysical Research Communications，2020

Discovery and Structural Catalytic Mechanism Studies of Novel Biosynthetic Enzymes

2023: Deputy Director-General of Science and Technology of Jiangsu Province

2022: Entrepreneurship and Innovation Doctorate of Jiangsu Province