Wangzongqiang

Dr. Wang Zongqiang, is professor, doctoral supervisor of China Pharmaceutical University. He obtained his Ph.D degree in China Pharmaceutical University and complete postdoctoral training at the Rockefeller University. Dr Wang’s research mainly focuses on discovering and studying the mechanisms of novel antimicrobial drugs, with a particular emphasis on the biosynthesis and chemical synthesis of polyketides (PKS) and nonribosmal peptides (NRP). He has published numerous research papers as first author and corresponding author in prestigious journals such as Nature, Science, Nat. Comm., and Angew. Chem. Int. Ed., and has filed for six international and domestic invention patents. Dr. Wang has taken charged of several national-level projects, including the National Natural Science Youth Fund and the National Key R&D Program (as the project leader), and has led the preclinical research of an antibiotic lead compound developed by his team. He has been appointed as a distinguished Professor in Jiangsu Province and a young editorial board member of the Chinese Journal of Natural Medicines. 

[1] Wang Z, Kasper A, Hernandez Y, et al. Tapcin, an in vivo active dual topoisomerase I/II inhibitor discovered by syn-BNP coupled metagenomics. Angewandte Chemie, 2024, e202317187.

[2] Wang Z, Koirala B, Hernandez Y, et al. Bioinformatic prospecting and synthesis of a bifunctional lipopeptide antibiotic that evades resistance. Science, 2022, 376(6596): 991-996.

[3] Wang Z, Forelli N, Hernandez Y, et al. Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis. Nature Communications, 2022, 13(1): 842.

[4] Wang Z, Koirala B, Hernandez Y, et al. A naturally inspired antibiotic to target multidrug-resistant pathogens. Nature, 2022, 601(7894): 606-611.

[5] Wang Z, Kasper A, Mehmood R, et al. Metagenome‐Guided Analogue Synthesis Yields Improved Gram‐Negative‐Active Albicidin‐and Cystobactamid‐Type Antibiotics. Angewandte Chemie, 2021, 133(41): 22346-22351.

1. Evolution-guided discovery and biosynthesis of high-valuable polyketide natural products

2. Bioinformatic prediction and displayed of non-ribosomal peptides

3. Mass spectrometer and bioinformatic-guided novel natural product discovery

4. Mechanism study of antimicrobial peptide