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Yehui

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E-mail：cpuyehui@cpu.edu.cn

Professional title：Professor

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  • Dr. Hui Ye, a professor and doctoral supervisor at China Pharmaceutical University, is recognized with the National Excellent Young Scientists Fund and the Jiangsu Provincial Distinguished Young Scientists Fund. Her research focuses on discovering active molecular targets via metabolism and proteomics technologies to identify new drug targets, with findings published in top journals like Nature Methods and Nature Chemical Biology. Her interdisciplinary work involves advanced metabolomics and proteomics techniques to uncover disease-related metabolic dysregulation, elucidate drug mechanisms, and design novel compounds for targeted therapy for cancer and neurodegenerative diseases.


    1. Tian Y‡ ,Wan N‡, Zhang HQ‡, Shao C‡, Ding M, Bao QY, Hu HY , Sun HY , Liu CG, Zhou K, Chen S, Wang G, Ye H*, Hao H*.Chemoproteomic mapping of the glycolytic targetome in cancer cells. Nat Chem Biol. 2023,19：1480-1491.

    2. Wan N‡, Wang N‡, Yu S, Zhang H, Tang S, Wang D, Lu W, Li H, Delafield DG, Kong Y, Wang X, Shao C, Lv L, Wang G, Tan R, Wang N*, Hao H*, Ye H*. Cyclic immonium ion of lactyllysine reveals widespread lactylation in the human proteome. Nat Methods. 2022, 19(7):854-864.

    3. Zhu Y‡, Wan N‡, Shan X, Deng G, Xu Q, Ye H*, Sun Y*. Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice. Acta Pharm Sin B (Cover Article). 2021, 11(5):1200-1212.

    4. Sang H‡ , Liu Jl‡ , Zhou F, Zhang XF, Zhang JW, Liu YZ, Wang GJ*, Ye H*. Target-responsive subcellular catabolism analysis for early-stage antibody‒drug conjugates screening and assessment. Acta Pharm Sin B. 2021, 11(12):4020-4031.

    5. Shao C, Lu W, Du Y, Yan W, Bao Q, Tian Y, Wang G, Ye H*, Hao H*. Cytosolic ME1 integrated with mitochondrial IDH2 supports tumor growth and metastasis. Redox Biol. 2020, 36:101685.

    6. Tian Y‡, Wan N‡, Ding M, Shao C, Wang N, Bao Q, Lu W, Hu H, Sun H, Yang C, Zhou K, Chen S, Wang G, Ye H*, Hao H*. Chemoproteomics Maps Glycolytic Targetome in Cancer Cells. bioRxiv. 2020, doi:10.1101/2020.11.18.387670.

    7. Lu G, Xu X, Li G, Sun H, Wang N, Zhu Y, Wan N, Shi Y, Wang G, Li L, Hao H*, Ye H*. Subresidue-resolution footprinting of ligand-protein interactions by carbene chemistry and ion mobility-mass spectrometry. Anal Chem. 2020, 92(1):947-956.

    8. Li Q‡, Cao L‡, Tian Y, Zhang P, Ding C, Lu W, Jia C, Shao C, Liu W, Wang D, Ye H*, Hao H*. Butyrate suppresses the proliferation of colorectal cancer cells via targeting pyruvate kinase M2 and metabolic reprogramming. Mol Cell Proteomics. 2018, 17(8):1531-1545.

    9. Ye H‡, Wang J‡, Tian Z, Ma F, Dowell J, Bremer Q, Lu G, Baldo B*, Li L*. Quantitative mass spectrometry reveals food intake-induced neuropeptide level changes in rat brain: functional assessment of selected neuropeptides as feeding regulators. Mol Cell Proteomics (Cover Article). 2017, 16(11):1922-1937.

    10. Wang L‡, Ye H‡, Sun D, Meng T, Cao L, Wu M, Zhao M, Wang Y, Chen B, Xu X, Wang G*, Hao H*. Metabolic pathway extension approach for metabolomic biomarker identification. Anal Chem. 2017, 89(2):1229-1237.


  • Prof. Hui Ye's research focuses on developing and implementing an array of novel analytical tools in the area of chemical proteomics and metabolomics to elucidate the direct binding targets of small molecules including natural medicines and endogenous metabolites, and gain new insights into how these functional molecules regulate protein function and signaling. The gained knowledge is translated to the design of compounds that potently modulate the activities of target proteins that are intimately associated with diseases such as cancer and immune diseases.


  • • CASMS Young Investigator Award (2022)

    • Science Foundation for the Distinguished Youth Scholars in Jiangsu Province (2022)

    • Young Scientific and Technological Talents Support Project of Jiangsu Provincial Association for Science and Technology (2019)

    • Six Talent Peaks Project of Jiangsu Province (2018)

    • Science Foundation for the Excellent Youth Scholars in Jiangsu Province (2018)

    • University of Wisconsin-Madison Vilas Travel Award (2012)


  • Analytical Pharmacology : chapter 4

    Cancer Metabolomics- -Chapter : Functional Metabolomics and Chemoproteomics Approaches Reveal Novel Metabolic Targets for Anticancer Therapy


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