Yuanhaoliang

Dr. Yuan is a distinguished associated professor and doctoral supervisor of Medicinal Chemistry at China Pharmaceutical University. He specializes in drug discovery and design with computer-aided methods and artificial intelligence. Till now, three projects hosted by Dr. Yuan have obtained financial supports from National Natural Science Foundation, one project is supported by Chongqing Natural Science Foundation, and two projects are supported by the Fundamental Research Funds for the Central Universities. Besides, he has published more than 20 SCI papers in the professional journals of medicinal chemistry, such as J. Med. Chem.，Eur. J. Med. Chem.，J. Chem. Inf. Model, and obtained 5 authorized patents.

(1) Panpan Chen#, Cai Chen#, Yizheng Zheng, Fangjun Chen, Zhaojun Liu, Shenhong Ren, Hangyu Song, Tongdan Liu, Zhipeng Lu, Hongbin Sun*, Yi Kong*, and Haoliang Yuan*. Discovery of 2, 3-dihydro-[1,4]dioxino[2,3-g]benzofuran Derivatives as Protease Activated Receptor 4 (PAR4) Antagonists with Potent Antiplatelet Aggregation Activity And Low Bleeding Tendency, J Med Chem 2024, 67:5502-5537.

(2) Liu Liu#, Honghan Zhang#, Jie Hou#, Yuying Zhang#, Luosen Wang, Shijun Wang, Zhiying Yao, Tao Xie, Xiaoan Wen, Qinglong Xu, Liang Dai, Zhiqi Feng, Pu Zhang, Yaojun Wu, Hongbin Sun*, Jun Liu*, Haoliang Yuan*. Discovery of Novel PD-L1 Small-Molecular Inhibitors with Potent In Vivo Anti-tumor Immune Activity, J Med Chem 2024, 67:4977-4997.

(3) Liu Liu#, Zhiying Yao#, Shijun Wang#, Tao Xie, Guoqing Wu, Honghan Zhang, Pu Zhang, Yaojun Wu, Haoliang Yuan*. Hongbin Sun*. Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[C][1,2,5]Oxadiazole Derivatives as Potent Pd-L1 Inhibitors with in Vivo Antitumor Activity. J. Med. Chem. 2021, 64, 8391-8409.

(4) Shengjie Liu, Xinyu Zhou, Minglei Li, Wenfeng Zhao, Shuxi Zhou, Ke-guang Cheng, Qing-Long Xu, Caiping Chen, Xiaoan Wen, Hongbin Sun*, Haoliang Yuan*. Discovery of Ubiquitin Specific Protease 7 (USP7) Inhibitors with A Novel Scaffold Structure by Virtual Screening, Molecular Dynamics Simulation and Biological Evaluation. J. Chem. Inf. Model, 2020, 60: 3255–3264.

(5) Haoliang Yuan#, Qiufeng Liu#, Li Zhang#, Shihe Hu, Tiantian Chen, Huifang Li, Yadong Chen, Yechun Xu*, Tao Lu*. Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors. Eur. J. Med. Chem. 2018, 143, 491-502.

Drug discovery and development for metabolic and autoimmune diseases with computer-aided methods and artificial intelligence.

Book：《Basis of Computer-Aided Drug Design》, Chapter 8, 2018.