Yujunjie

PhD, 2009-2014, Institute of Nutritional Science (INS), Chinese Academy of Sciences (CAS) on 2014, majored in biochemistry and molecular biology;

Research assistant, 2014-2015, INS, CAS;

Postdoc/Associate research scientist, 2015-2022, Columbia University;

Professor, 2022-present, China Pharmaceutical University.

1. J. Yu*, C. Zhu, X. Wang, K. Kim, A. B. Bartolome, P. Dongiovanni, K. P. Yates, L. Valenti, M. Carrer, T. Sadowski, L. Qiang, I. Tabas, J. E. Lavine and U. B. Pajvani, Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH- induced fibrosis. Sci Transl Med 13, eabe1692 (2021).

2. Q. Liu*, J. Yu*, L. Wang, Y*. Tang, Q. Zhou, S. Ji, Y. Wang, L. Santos, R. A. Haeusler, J. Que, P. Rajbhandari, X. Lei, L. Valenti, U. B. Pajvani, J. Qin, L. Qiang, Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis. J Hepatol 73, 361-370 (2020).

3. J. Yu*, F. Xiao, Y. Guo, J. Deng, B. Liu, Q. Zhang, K. Li, C. Wang, S. Chen, F. Guo, Hepatic Phosphoserine Aminotransferase 1 Regulates Insulin Sensitivity in Mice via Tribbles Homolog 3. Diabetes 64, 1591-1602 (2015).

4. F. Xiao*, J. Yu*, B. Liu, Y. Guo, K. Li, J. Deng, J. Zhang, C. Wang, S. Chen, Y. Du, Y. Lu, Y. Xiao, Z. Zhang, F. Guo, A novel function of microRNA 130a-3p in hepatic insulin sensitivity and liver steatosis. Diabetes 63, 2631-2642 (2014).

5. H. Liu*, J. Yu*, T. Xia, Y. Xiao, Q. Zhang, B. Liu, Y. Guo, J. Deng, Y. Deng, S. Chen, A. Naray-Fejes-Toth, G. Fejes-Toth, F. Guo, Hepatic serum- and glucocorticoid-regulated protein kinase 1 (SGK1) regulates insulin sensitivity in mice via extracellular-signal-regulated kinase 1/2 (ERK1/2). Biochem J 464, 281-289 (2014).

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease, ranging from steatosis, non-alcoholic steatohepatitis (NASH), fibrosis to the life-threatening cirrhosis and hepatocellular carcinoma (HCC). The molecular mechanism underlying the NAFLD progression still requires more investigation. Based on RNAseq data from different NASH and HCC mice models, our lab is studying how hepatocyte-non-parenchymal cell communication mediated the development of NASH, and how NASH progress to HCC.

2017, Berrie fellow in Diabetes research