Zhangfangfang

Zhang Fangfang, a new drug researcher and master's supervisor. Focusing on the major needs of the national health cause, we carried out basic and application work around the clinical problem of diabetes, a difficult chronic disease, and applied multidisciplinary cross technology to deeply tap the key targets for regulating the functional and metabolic remodeling of pancreatic beta cells from the perspective of the steady state of the interaction between cells and organs, so as to provide a theoretical basis for the clinical treatment of diabetes. Obtained multiple original and pioneering research achievements, as the first author and co corresponding author at Nat Commun. (202020212023), Diabetes 2022, Diabetologia 2020 Published 5 academic papers. For the first time, the mechanism by which metabolic disorders drive the dynamic expression of pancreatic ncRNA and mediate the occurrence of T2DM has been analyzed, and key ncRNA regulatory rules have been elucidated in multiple dimensions. Obtained 4 authorized patents. Based on the above work, I have successively led six scientific research projects, including the National Natural Science Foundation of China (General, Youth Fund) and the Jiangsu Provincial Natural Science Foundation Youth Fund. One research achievement won the second prize of National Science and Technology Progress Award by the Ministry of Education (September 12, 2022).

① Fangfang Zhang, Dongshen Ma, Wanli zhao, Danwei Wang, Tingsheng Liu, Yue Liu, Yue Yang, Yuho ng Liu, Jinming Mu, Bingbing Li, Yanfeng Zhang, Yi Pan, Changying Guo, Hong Du, Ling Li, Xianghui Fu*, Zhengyu Cao*, Liang Jin*, Obesity-induced overexpression of miR-802 impairs insulin transcription and secretion. Nature Communications, 2020, 11(1): 1822.

② Fangfang Zhang^#, Yue Yang^#, Xi Chen, Yue Liu, Qianxing Hu, Bin Huang, Yuhong Liu, Yi Pan, Yanfeng Zhang, Dechen Liu, Rui Liang, Guoqing Li, Qiong Wei*, Ling Li*, Liang Jin*, The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice. Nature Communications, 2021;12(1):3997.

③ Fangfang Zhang, Yuhong Liu, Danwei Wang, Tingsheng Liu, Yue Yang, Jiamin Guo, Yi Pan, Yanfeng Zhang, Hong Du, Ling Li, Liang Jin*, Obesity-induced reduced expression of lncRNA ROIT impairs insulin transcription by downregulation of Nkx6.1 methylation. Diabetologia, 2020, 63(4): 811-824. 

④  Yue Liu; Yue Yang; Chenying Xu; Jianxing Liu; Jiale Chen; Guoqing Li; Bin Huang; Yi Pan; Yanfeng Zhang; Qiong Wei; Stephen J. Pandol; Fangfang Zhang*; Ling Li*; Liang Jin*; Circular RNA circGlis3 protects against islet β-cell dysfunction and apoptosis in obesity, Nature Communications, 2023, 14(1): 351.

⑤ Qianxing Hu^#, Jinming Mu^#, Yuhong Liu^#, Yue Yang, Yue Liu, Yi Pan, Yanfeng Zhang, Ling Li, Dechen Liu, Jianqiu Chen*, Fangfang Zhang*, Liang Jin*, Obesity-induced miR-455 upregulation promotes adaptive pancreatic β-cell proliferation through the CPEB1/CDKN1B pathway. Diabetes, 2022, 71(3): 394-411. 

① National Natural Science Foundation project，circPde5a mediates mitochondrial-endoplasmic reticulum communication to maintain calcium homeostasis and improve pancreatic islet function. 82370804，2024.01-2027.12，490000；

② National Natural Science Foundation project，Mechanisms of the miR-802/TRAF3 pathway in obesity-induced adipose inflammation and insulin resistance. 82070801， 2021.01-2024.12，570000；

③ Jiangsu Province Natural Science Foundation Youth Fund，Mechanistic study of the downregulation of lncRNA Traf3ip2 as a mediator of pancreatic β-cell dysfunction in obesity. BK20200569，2020.07-2023.06，200000；

④ National Postdoctoral Science Foundation 15th Special grant，The mechanism of lnc-βFaar/Rab18 in improving insulin resistance by maintaining lipid homeostasis in adipose tissue. 2022T1550726，2022.07-2023.07,180000.