Zhangheng

Dr. ZHENG’s research focuses on the research and development of antimicrobial drugs, especially on the antimicrobial peptides. He is an expert in the field of computer aided drug design, discovered several novel metallo-β-lactamase inhibitors, which severed as potential drug candidates for multiple-drug-resistant bacteria. He is also specialize in protein structure prediction, molecular docking, and molecular dynamics. He published more than 50 papers, obtained 5 Chinese invention patents in recent years.

1. Shi G, Kang X, Dong F, Liu Y, Zhu N, Hu Y, Xu H, Lao X*, ZhengH*. DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides[J]. Nucleic Acids Research, 2022,50(D1): D488–D496

2. Zhu N, Dong F, Shi G, Lao X* , Zheng H*. Hordb a comprehensive database of peptide hormones[J]. Scientific Data, 2022, 9:187

3. Shi C，Dong F，Zhao G，Zhu N，Lao X *，Zheng H *. Applications of machine-learning methods for the discovery of NDM-1 inhibitors[J]. Chemical Biology & Drug Design, 2020. 96(5):1232-1243

4. Chen, JX;Shi, C;Kang, XY;Shen, XT;Lao, XZ*; Zheng, H*. Recent advances in fluorescence resonance energy transfer-based probes in nucleic acid diagnosis[J]. Analytical methods, 2020, 12(7)：884

5. Shi, C;Chen, JX;Kang, XY;Zhao, GL;Lao, XZ*;Zheng, H*. Cheng S , Jiaxing C , Xinyue K , et al. Deep Learning in the Study of Protein-Related Interactions[J]. Protein and Peptide Letters, 2020, 27(5):359-369  

6. Cheng Shi,Jiaxin Chen,Bing Xiao,Xinyue Kang,Xingzhen Lao*, Zheng Heng*. Discovery of NDM-1 inhibitors from natural products. J Glob Antimicrob Resist 2019, 18:80-87  

7. Cheng Shi,Jingxiao Bao,Ying Sun,Xinyue Kang,Xingzhen Lao*, Zheng Heng*. Discovery of Baicalin as NDM-1 inhibitor: Virtual screening, biological evaluation and molecular simulation. Bioorg Chem 2019, 88:102953

8. X Kang, F Dong, C Shi, S Liu, J Sun, J Chen, H Li, H Xu, X Lao* ,H Zheng*. DRAMP 2.0, an updated data repository of antimicrobial peptides. Scientific Data. 2019,6.148

1. Take charge of National Natural Science Foundation of China: Optimization and verification of antibacterial peptide druggable properties based on deep neural network learning, in progress

2. Take part in The Twelfth Five-Year National Major Scientific and Technological Special Project for Significant New Drugs Development: Research and development of significant polypeptide drugs such as Antiangiogenic Peptides, completed

1. First prize of the Ministry of Education's Technology Invention Award (ranked third)

2. The third prize of the Ministry of Education's Huo Yingdong Young Teacher Award

3. The Youth Biology Award of the Chinese Pharmaceutical Association

4. The Six Talent Peaks in Jiangsu Province

1. Associate Editor: ”Biopharmaceutical Process”, Fifth Edition, China Medical Science and Technology Press, 2019

2. Editor in Chief: Pharmaceutical Bioinformatics , Chemical Industry Press, 2004