Zhangqiuyue

Dr. Zhang is a distinguished associate professor of Medicinal Chemistry at China Pharmaceutical University, with a profound commitment to advancing our understanding of drug discovery. Holding a Ph D. in Medicinal Chemistry from China Pharmaceutical University, Dr. Zhang specializes in developing first-in-class small-molecule regulators targeting the phosphorylation modulation of proteins. 

1. Zhang, Q. Y.^#; Yan, L.^#; Zhang, L. X.^#; Yu, J.; Han, Z. Y.; Liu, H.; Gu, J. Y.; Wang, K. R.; Wang, J. Y.; Chen, F. S.; Zhao, R. D.; Yan, Y.; Jiang, C.*; You, Q. D.*; Wang, L.*. Allosteric Activation of Protein Phosphatase 5 with Small Molecules. J. Med. Chem. 2024. (IF: 6.8) 

2. Han, Z. Y.; Shen, Z. K.; Pei, J. Y.; You, You, Q. D.*; Zhang, Q. Y.*; Wang, L.*. Transformation of peptides to small molecules in medicinal chemistry: Challenges and opportunities. Acta Pharm. Sin. B 2024. (IF: 14.7)

3. Zhang, Q. Y. ^#; Yan, L.^#; Zhang, Y. X.; Zhang, L. X.; Yu, J.; You, Q. D.*; Wang, L.* Rational design of peptide inhibitors targeting HSP90-CDC37 protein-protein interaction. Future Med. Chem. 2024, 16 (2), 125-138. 9. (IF:3.2)

4. Zhang, Q. Y.; Wu, X. X.; Zhang, H. H.; Wu, Q. Y.; Fu, M.; Hua, L. W.; Zhu, X. Y.; Guo, Y. Q.; Zhang, L. S.*, You, Q. D.*, Wang, L.*. Protein phosphatase 5-recruiting chimeras for accelerating apoptosis signal-regulated kinase 1 dephosphorylation with antiproliferative activity. J. Am. Chem. Soc. 2023, 145(2), 1118-1128. (IF: 14.5)

5. Hua, L.W.; Wang, D. N.; Wang, K. R.; Wang, Y. X.; Gu, J. Y.; Zhang, Q. Y.*; You, Q. D.*; Wang, L.* Design of tracers in fluorescence polarization assay for extensive application in small molecule drug discovery. J. Med. Chem. 2023, 66(16):10934-10958. (IF:6.8)

6. Hua, L. W. ^#; Zhang, Q. Y. ^#; Zhu, X. Y.; Wang, R. N.; You, Q. D.*; Wang, L.*, Beyond Proteolysis-Targeting Chimeric Molecules: Designing Heterobifunctional Molecules Based on Functional Effectors. J. Med. Chem. 2022, 65(12), 8091-8112. (IF: 6.8)

7. Wu, X. X.^#; Zhang, Q. Y.^#; Guo, Y. Q.; Zhang, H. H.; Guo, X. K.*; You, Q. D.*; Wang, L.*, Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein-Protein Interactions: An Update. Antioxidants. 2022, 11 (4). (IF: 7.7)

8. Zhang, Q. Y.; Fan, Z. J.; Zhang, L. S.; You, Q. D.*; Wang, L.*, Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer. J. Med. Chem. 2021, 64(13), 8916-8938. (IF: 6.8) 

9. Zhang, Q. Y.^#; Wu, X. X.^#; Zhou, J. R.; Zhang, L. X.; Xu, X. L.; Zhang, L. S.*; You, Q. D.*; Wang, L.* Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core. Eur. J. Med. Chem. 2021, 210, 112959. (IF:6.0)

10. Wang, L.; Zhang, Q. Y.; You, Q. D.*, Targeting the HSP90-CDC37-kinase chaperone cycle: A promising therapeutic strategy for cancer. Med. Res. Rev. 2021. 42 (1), 156-182. (IF: 12.9)

Wang, L.; Jiang, J. S.; Zhang, L. X.; Zhang, Q. Y.; Zhou, J. R.; Li, L.; Xu, X. L.*; You, Q. D.*, Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. J. Med. Chem. 2020, 63 (3), 1281-1297. (IF: 6.8)

Discovery and development of first-in-class small-molecule regulators targeting phosphorylation modulation of proteins.

2023, the Excellent Doctoral Dissertation of Jiangsu Province