Zhoutianjiao

1、Educational Experience

09/2011-06/2015Xinxiang Medical UniversityBachelor of Science in pharmaceutic preparation

09/2015-06/2018China Pharmaceutical UniversityMaster of pharmacy

09/2018-06/2021China Pharmaceutical UniversityPhD in pharmaceutics

2、Working Experience

07/2021-NowChina Pharmaceutical UniversityPostdoc in pharmaceutics

1. Yang MY^#, Lin YJ^#, Han MM, Bi YY, He XY, Xing L, Jeong JJ, Zhou TJ^*, Jiang HL^*. Pathological collagen targeting and penetrating liposomes for idiopathic pulmonary fibrosis therapy. Journal of Controlled Release. 2022, 351, 623-637. (IF: 11.467)

2. Zhou TJ^#, Xu Y^#, Gong YH^#, Yu MT, Xu EZ, Aimaiti W, Ma RJ, Xing Lei, Wen Hao^*, Wang JH^*, Jiang HL^*. Breaking-then-curing strategy for efficient cystic echinococcosis therapy. Chinese Chemical Letters. 2022, 33, 6, 2949-2953. (IF: 6.779)

3. Zhou TJ, Xu Y, Xing L, Wang Y, Jiang HL^*. A harmless-harmful switchable and uninterrupted laccase-instructed killer for activatable chemodynamic therapy. Advanced Materials. 2021, 33, 27, e00114. (IF: 30.849)

4. Xing L^#, Liu XY^#, Zhou TJ^#, Wan X, Wang Y, Jiang HL^*. Photothermal nanozyme-ignited Fenton reaction-independent ferroptosis for breast cancer therapy. Journal of Controlled Release. 2021;339:14-26. (IF: 9.776)

5. Wang Y^#, Hu LF^#, Zhou TJ^#, Qi LY, Xing L, Lee J, Wang FZ*, Oh YK^*, Jiang HL^*. Gene therapy strategies for rare monogenic disorders with nuclear or mitochondrial gene mutations. Biomaterials. 2021, 277,121108. (IF: 12.479)

6. Zhou TJ^#, Xing L^#, Fan YT, Cui PF, Jiang HL^*. Light triggered oxygen-affording engines for repeated hypoxia-resistant photodynamic therapy. Journal of Controlled Release. 2019, 307, 44-54. (IF: 7.727)

7. Zhou TJ^#, Xing L^#, Fan YT^#, Cui PF, Jiang HL^*. Inhibition of breast cancer proliferation and metastasis by strengthening host immunity with a prolonged oxygen-generating phototherapy hydrogel. Journal of Controlled Release. 2019, 309, 82-93. (IF: 7.727)

8. Shen LJ^#, Zhou TJ^#, Fan YT, Chang X, Wang Y, Sun J, Xing L^*, Jiang HL^*, Recent progress in tumor photodynamic immunotherapy, Chinese Chemical Letters. 2020, 31, 7, 1709-1716. (IF: 6.779)

9. Fan YT^#, Zhou TJ^#, Cui PF, He YJ, Chang X, Xing L^*, Jiang HL^*. Modulation of intracellular oxygen pressure by dual‐drug nanoparticles to enhance photodynamic therapy. Advanced Functional Materials. 2019, 29,10, 1806708. (IF: 16.836)

10. Luo CQ^#, Zhou YX^#, Zhou TJ^#, Xing L, Cui PF, Sun M, Jin L, Lu N*, Jiang HL^*. Reactive oxygen species-responsive nanoprodrug with quinone methides-mediated GSH depletion for improved chlorambucil breast cancers therapy. Journal of Controlled Release. 2018, 274, 56-68. (IF: 7.901)

Smart Drug Delivery System

1、Research Projects

2022.01-2023.12The 70^th batch of China Postdoctoral Science Foundation, 2021M703598, Application of nanoreactors that catalyze lactate metabolism to induce ferroptosis in the treatment of metastatic breast cancer, 80,000 RMB, Principle Investigator.

2022-JulyProjects dispatched by China Postdoctoral International Exchange Program, 300,000 RMB

2022-MayOutstanding Postdoctoral Program of Jiangsu Province, 300,000 RMB

2、Academic Awards

2021-JulyExcellent Doctoral Dissertation of China Pharmaceutical University

2019-OctoberNational Scholarship for Doctoral Students

2019-JulyThe best poster of 2019 Asian Association of Schools of Conference in Suwon, Korea

3、Representative Research Achievements

A harmless-harmful switchable and uninterrupted laccase-instructed killer for activatable chemodynamic therapy

Project brief introduction: To prepare a low-toxic and effective anticancer chemodynamic therapy (CDT) agent, a harmless-harmful switchable and uninterrupted laccase (LAC)-instructed killer (HULK) was designed, which is the first CDT agent accelerated by LAC-instructed O₂^{− •} generation and possesses harmless-harmful switchable effect because of the photodegradation of O₂^{− •} scavenger Fe(Cl)-chlorin e6 (FeCe6), showing great potential as a safe and effective CDT agent.

Light triggered oxygen-affording engines for repeated hypoxia-resistant photodynamic therapy

Project brief introduction: To alleviate tumor hypoxia for improved PDT treatment, we designed an innovative biological oxygen-evolving material, named autotrophic light-triggered green affording-oxygen engine (ALGAE), which could perform an on-off switchable and inexhaustible oxygen generation triggered by the same irradiation of PDT with good biocompatibility and degradability.