Zhangxiangyu

Dr. Zhang received his Ph.D. degree in organic chemistry from University College London (UCL) in the UK, supervised by Prof. Jim Anderson (FRSC).  Then he joined China Pharmaceutical University as a Lecturer in 2020, and his research interest is focused on the total synthesis of complex bioactive molecules and related drug discovery for cancer therapy. 

Research Interests:

1. Synthetic methodology development and bio-active molecules’ Synthesis;

2. Small-molecule medicinal chemistry;

3. Process chemistry of active API manufacturing

1. X. Zhang, Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours. Nat. Prod. Rep. 2024, Advance Article (DOI:10.1039/d3np00048f)

2. K. Wang‡, X. Zhang‡, Y. Cheng, Z. Qi, K. Ye, K. Zhang, S. Jiang, Y. Liu, Y. Xiao, T. Wang, Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy. J. Med. Chem. 2023, 66, 16807.

3.T. Wang ‡, K. Wang ‡, Y. Zhang, K.Zhang, S. Cai, S. Jiang*, Y. Xiao*, X. Zhang*, Novel Benzimidazoles as Potent Small-Molecule Inhibitors and Degraders of V‐Domain Ig Suppressor of T‐Cell Activation (VISTA). J. Med. Chem. 2023, 66, 11881.

4.K.Zhang, T, Wang, M. Li, M. Liu, H. Tang, L. Wang, K. Ye, J. Yang, S. Jiang, Y. Xiao, Y. Xie*, M. Lu*, X.Zhang*, Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro). Eur. J. Med. Chem. 2023, 257, 115487.

5.X．Zhang, J. C. Anderson*, A Divergent Synthetic Route to the Vallesamidine and Schizozygine Alkaloids: Total Synthesis of (+)-Vallesamidine and (+)-14,15-Dehydrostrempeliopine. Angew. Chem. Int. Ed. 2019, 58, 18040. 

1, Nitro group chemistry and novel applications in natural products and drugs’ synthesis;

2, Process chemistry of highly active API’s manufacturing (e.g. prostaglandins);

3, Small-molecule inhibitors’ development targeting immune checkpoint and evaluations in cancer therapy.