Zhuyong

Graduated with a Ph.D. from China Pharmaceutical University in 2010, and thereafter worked in the Department of Organic Chemistry at the School of Science. From September 2014 to October 2015, conducted research as a visiting scholar in the Department of Chemistry and Chemical Biology at Harvard University. Currently, mainly engaged in teaching organic chemistry and conducting research in medicinal chemistry. The major research areas include the design, synthesis, biological activity, and mechanism of action of targeted small molecule drugs; research on small molecule probes; and the study of synthesis processes for drugs and intermediates.

1. Zhaozhao Wang; Shu Qu; Jiahao Yuan; Wen Tian ; Jinglei Xu ; Rui Tao ; Shilong Sun ; Tao Lu ; Weifang Tang ; Yong Zhu ; Review and prospects of targeted therapies for Spleen tyrosine kinase (SYK), Bioorganic Medicinal Chemistry, 2023, 96(12): 117514

2. Hao Cui ; Zan Hu ; Kang Yang ; Jingkun Huang ; Yichao Wu ; Quanwei Chen ; Ran Wei ; Penfeng Wang ; Hui Wang ; Hongmei Li ; Yadong Chen ; Tao Lu ; Yuqin Yao ; Yong Zhu ; Design and synthesis of highly TRAIL expression HDAC inhibitors based on ONC201 to promote apoptosis of colorectal cancer, European journal of medicinal chemistry, 2022, 238: 114484-114484

3. Hao Cui ; Qianqian Hong ; Ran Wei ; Hongmei Li ; Chunyang Wan ; Xin Chen ; Shuang Zhao ; Haizhi Bu ; Bingxu Zhang ; Dexiao Yang ; Tao Lu ; Yadong Chen ; Yong Zhu ; Design and synthesis of HDAC inhibitors to enhance the therapeutic effect of diffuse large B-cell lymphoma by improving metabolic stability and pharmacokinetic characteristics, European Journal of Medicinal Chemistry, 2022, 229(229)

4. Hao Cui; Jingkun Huang; Yan Lei; Quanwei Chen; Zan Hu; Jiaqi Niu; Ran Wei; Kang Yang; Hongmei Li; Tao Lu; Yong Zhu; Yatian Huang; Design and Synthesis of Dual Inhibitors Targeting Snail and Histone Deacetylase for the Treatment of Solid Tumour Cancer, European Journal of Medicinal Chemistry, 2022, 229(229)

Research on targeted small molecule inhibitors based on tumor immunotherapy;

Research on targeted small molecule degraders.