Sheng Jiang

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Sheng Jiang
Sheng Jiang, Ph. D.
 PROFESSIONAL EXPERIENCE
 2017 ~ Present            China Pharmaceutical University
2008 ~ 2016                   Research Professor; Laboratoryof Medicinal Chemistry
Guangzhou Institute of Biomedicine and Health, CAS
2003 ~ 2008                   Postdoctoral Fellow, Laboratory of Medicinal Chemistry, National Cancer Institute, NIH
  EDUCATION
 2003      Ph. D.    Department of organic chemistry, Shanghai Institute of Organic Chemistry, Shanghai, China 
2000      M.S.      Department of medicinal chemistry, China Pharmaceutical University, China                           
1997      B.S.      Department of medicinal chemistry, China Pharmaceutical University, China
 HONORS
 2011    CPA-Servier Young Investigator Awards in Medicinal Chemistry
2010    Hundred Talent Award
2009    Eastern Scholarship Award
2006    NIH Fellows award for the Research Excellence        
1996      “Suzhou Capsule” Scholarship, awarded by China Pharmaceutical University
PROFESSIONAL SOCIETY
2004-present       Member of American Chemical Society
2005-present       Member of American Peptide Society
2008-present       Chinese Chemical Society
2009-present       Chinese Pharmaceutical Association
 Presentation:
1. Sheng Jiang (invited speaker), “Discovery of Novel Class I Histone Deacetylase Inhibitors through Total Synthesis of Natural Products”, National Cancer Institute 2015 (2015,10,20 Fredercik, US).
2. Sheng Jiang (invited speaker), “Discovery of Novel Class I Histone Deacetylase Inhibitors through Total Synthesis of Natural Products”, Chinese Pharmaceutical University 2015 (2015,7,10 Nanjing, China).
3. Sheng Jiang (invited speaker), “Discovery of Novel Class I Histone Deacetylase Inhibitors through Total Synthesis of Natural Products”, The 4th Natural Product Synthesis-Young Investigator Forum (2015,7, Chendu, China).
4. Sheng Jiang (invited speaker), “Discovery of Novel Class I Histone Deacetylase Inhibitors”, CCS 10th  National Symposium on Natural Organic Chemistry (2014,11 Guangzhou, China).
5. Sheng Jiang (invited speaker), “Design, Synthesis and Biological Evaluation of Novel Class I Histone Deacetylase Inhibitors through Total Synthesis of Natural Products”, 2012 (Shanghai, China).
6. Sheng Jiang (invited speaker), “From Total Synthesis of Natural Products to Discovery of New Histone Deacetylase Inhibitors”, The 4th China-Thailand Workshop on Natural Products and Drug Discovery, Trang Province, Thailand, November 26-30, 2012
7. Sheng Jiang (invited speaker), “Discovery of New Histone Deacetylase Inhibitors”, The 28th CCS National Congress (2012, Chendu, China)
8. Sheng Jiang (invited speaker), “Design and synthesis New Histone Deacetylase 1 (HDAC1) inhibitors as potential anticancer drugs”, National Cancer Institute, Frederick, MD, 2010
9. Sheng Jiang (invited speaker), “Total Synthesis of Largazole and its analogues potential anticaner drugs”, The 5th CCS National Congress on organic chemistry (2009, Xian, China).
10. Sheng Jiang (invited speaker), “Potent antagonists of the Grb2-SH2 domain: Not relying on phosphotyrosine mimics”, Chinese Pharmaceutical University 2006 (2006, Nanjing, China).
11. Sheng Jiang, et al. “Potent antagonists of the Grb2-SH2 domain: Not relying on phosphotyrosine mimics”, 232th American Chemical Society Meeting (9/10-9/14, 2006).
12. Sheng Jiang, et al. “Synthesis and Evaluation of Analogs of SFTI-1, Potent Inhibitors of the Type II Transmembrane serine protease, Matriptase”, 230th American Chemical Society Meeting (8/28-9/1, 2005).
13. Sheng Jiang, et al. “Synthesis of Symmetrical Dimeric Dicarboxylic Acid Linked Peptides on Solid support”, 19 th American Peptide Symposium (6/18-23, 2005).
14. Sheng Jiang, et al. “First Chemical Synthesis of Butenolide 2”, The 2nd CCS National Congress on organic chemistry and the 1st CCS National Congress on Chemical Biology (2002, China).
 
Patents:
1.  “Synthesis and application of ether bond modified chiral annonaceous acetogenins compound”
Licensed to Shanghai Institute of Organic Chemistry
Inventors: Z. J. Yao, Y. L. Wu and S. Jiang.
Patent No. CN1477103
2.  “Method for synthesis of largazole and its analogs as antitumor agents.”
Inventors: S. Jiang, G. Zhou, B. Yin, X. Zeng, and Z. Hu.
Patent No. CN 101781321
3.  “Annonaceous acetogenins analogs as antitumor agents and their preparation, pharmaceutical compositions and use in the treatment of cancer”
Inventors: S. Jiang, Z.J. Yao, G. Zhou, Q. Xiao, Y. Liu
Patent No. CN 101982464
4.  “Preparation of cyclopeptides as histone deacetylase inhibitors”
Inventors: S. Jiang, S. Li, Y. Yao, F. Zhang, Y. Chao, H. Ye, M. Chen 
CN Patent Serial No. CN102391359
5.  “Preparation of triazole compounds as histone deacetylase inhibitors.”
Inventors: S. Jiang, Z. Tu, Y. Yao, C. Liu, H. Yao, X. Xue,
Patent No. CN 102311398
6.  “Process for preparation of FK228”
Inventors: S. Jiang, J. Xu, S. Li, H. Yao, X. Zeng,  Y. Yao,
Patent No. CN 102276689
7. “Quinoxalinyl bis(N-oxide) derivatives and their application as ligands in Cu-catalyzed C-O coupling reaction”
Inventors: Z. Yao, S. Jiang, 
Patent No. CN 102060790
8. “Quinoline derivative-N-oxide ligands, their preparation method and application in N-C coupling”
Inventors: Z. Yao,  S. Jiang, 
Patent No. CN 101899003

  1. “Method for preparing epichlorohydrin tetramer and its reaction with   formaldehyde derivative”

        Inventors: D. Zhang, J. Su, S. Jiang, 
Patent No. CN 103864727

  1.   “Preparation of largazole analog compounds as antitumor agents”

         Inventors: S. Jiang, Z. Tu, X. Li, Y. Yao, Y. Qiu
Patent No. CN 103601742
11.  “13-membered cyclic peptide as histone deacetylase inhibitor and its preparation”
    Inventors: H. Xiang, G. Wang, S. Jiang, Z. Tu,
Patent No. CN 103232474
12.  “Preparation of N-containing heterocyclic derivatives as histone deacetylase I inhibitor”
Inventors: S. Jiang, Z. Tu, Q. Sun, C. Liu, Y. Yao, Y. Qiu,
Patent No. CN 103086971
13. “Preparation of 3-(pyridin-3-yl)acrylamide derivatives as nicotinamide phosphoribosyltransferase inhibitors useful for the treatment of cancer”
      Inventors: S. Jiang, Z. Tu, D. Zheng, D. Qin, J. Bai, X. Qin, Y. Yao, Y. Liu, Y. Qiu, J. Chen
      Patent No. CN 104557863/PCT 090572
 Manuscript reviewer:
Organic Letters,       Journal of Organic Chemistry,          Journal of Medicinal Chemistry,
Bioorganic Medicinal Chemistry Letters,          Europe Journal Medicinal Chemistry,
Organic & Biomolecular Chemistry,            Tetrahedron,    Bioorganic Medicinal Chemistry,
Tetrahedron Letters,       Chemical Communications,

 RESEARCH SUPPORT
Ongoing support

International Cooperation Special Grant from the Science and Technology Development Project of

Guangdong Province (Sheng Jiang)                                                         06/01/2016-06/31/2018
                                                                                                                                            ¥500,000
“Design of radiotracers for in Vivo PET Imaging of Class I Histone deacetylases”
Role: PI
 
National Natural Science Foundation (Sheng Jiang)                                    01/01/2015-12/31/2018
                                                                                                                                            ¥900,000
“Total synthesis of Flueggines A and B ”
Role: PI
 
Guangdong Scientific Program for Drug Discovery  (Sheng Jiang)                          01/01/2015-12/31/2017
                                                                                                                                            ¥1,500,000
“The Pre-clinical Evaluation of AA005 as potential anti-cancer drugs
Role: Co-PI
 
 

Completed Research Support

 
National Major Scientific and Technological Program for Drug Discovery  (Sheng Jiang)
01/01/2009 to 12/31/2010                                                                                                     ¥1,260,000  
 “The biological study of analog of Annonaceous Acetogenins (AA005) as potential anti-cancer drugs ”
Role: PI
 
NN-CAS Research Foundation  (Sheng Jiang)                                             01/01/2009 to 12/31/2010                                                                                                       ¥500,000
 “Design and Synthesis of Peptides  Inhibitors of Matriptase ”
Role: PI
 
The Key Project of Knowledge Innovation Program of the Chinese Academy of Sciences  (Sheng Jiang)
01/01/2010 to 12/31/2010                                                                                                     ¥200,000
“Design, Synthesis and Biological study of Novel  Inhibitors of Matriptase ”
Role: PI
 
Guangdong Provincial Natural Science Foundation (Sheng Jiang)                01/01/2009 to 12/31/202010                                                                                                ¥50,000
 “Design and Synthesis  of Small moleculs  Inhibitors of Matriptase ”
Role: PI
                                         
National Natural Science Foundation (Sheng Jiang)                                    01/01/2009-12/31/2011
                                                                                                                                            ¥180,000
“Design, Synthesis and Biological study of Cyclic peptides  Inhibitors of Matriptase”
Role: PI
973 Foundation (Sheng Jiang)                                      01/01/2009-12/31/2013
                                                                                                                                     ¥1,300,000
“Construction of library of small molecular to modulate the stem cell”
Role: PI
 
National Natural Science Foundation (Sheng Jiang)                                    01/01/2010-12/31/2012  
                                                                                                                                            ¥350,000
“Total synthesis of Argyrin A”
Role: PI

 

National Natural Science Foundation (Sheng Jiang)                                    01/01/2012-12/31/2015
                                                                                                                                            ¥600,000
“Design, Synthesis and Biological Evaluation of Novel Histone Deacetylase Inhibitors”
Role: PI
 
 
PUBLICATIONS
 

  1. J. Bai, , C. Liao, D. Qin, Y. Liu, X. Qing, J. Chen, Z. Li, Z. Tu, S. Jiang.* Structure-Based Design of Potent Nicotinamide Phosphoribosyltransferase Inhibitors with Promising In Vitro and in Vivo Antitumor Activities. J. Med. Chem. 2016, 59, 5766-5779.

  2. Y. Jin, Y. Yao, L. Chen, X. Zhu, B. Jin, Y. Shen, J. Li, X. Du, Y. Lu, S. Jiang*, J. Pan*. Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with imatinib. Theranostics. 2016, 6, 1947-1962.

  3. N. Ma, Y. Luo, Y. Wang, C. Liao, W.-C. Ye*, S. Jiang*. Selective histone deacetylase inhibitors with anticancer activity. Curr. Top. Med. Chem. 2016, 16, 415-426. 

  4. N. Ma, Y. Wang, B. Zhao, W.-C. Ye*, S. Jiang*. The application of click chemistry in the synthesis of agents with anticancer activity. Drug Design, Development and Therapy. 2015, 50, 1585-1599. 

  5. Y. Yao, Z. Tu, C. Liao, Z. Wang, S. Li, H. Yao, Z. Li, S. Jiang*. Discovery of Novel Class I Histone Deacetylase Inhibitors with Promising in Vitro Selectivity for Cancers Cells and in Vivo Antitumor Activities. J. Med. Chem. 201558, 7672-7680.

  6. Y. Yao, Z. Li, Y. Qiu, J. Su, S. Jiang*. Unprecedented reactions: from epichlorohydrin to epoxyglycidyl substituted divinyl ether and its conversion into epoxyglycidyl propargyl ether. ScientificReports. 2015,5, srep14231.

  7. J. Zhang, H. Zhou, S. Jiang, J. Jin, W. Li, W. Wang, S. Su. AA092, an annonaceous acetogenin mimetic, attenuates angiogenesis in a mouse model of inflammation-induced corneal neovascularization. International Immunopharmacology. 2015, 28, 997-1002.

  8. Y. Zhou, G. Hou, S. He, Z. Xiao, H. Xu, Y. Qiu, S. Jiang, H. Zheng, Z. Li. Psora-4, a Kv1.3 Blocker, Enhances Differentiation and Maturation in Neural Progenitor Cells. CNS Neuroscience & Therapeutics. 2015, 21, 558-567.

  9. N. Ma, Y. Yao, B.-X. Zhao, Y. Wang, W.-C. Ye*, S. Jiang*. Total synthesis of securinega alkaloids (-)-norsecurinine, (-)-niruroidine and (-)-flueggine A. Chem. Commun. 2014, 50, 9284-9287. 

  10. X. Zhu, L. Chen, S. Jiang, C. Chen, Y. Yao, D. Chen, H. Xue, J. Pan *. PQJS380: a novel lead compound to induce apoptosis in acute lymphoblastic leukemia cells. Cancer Biology & Therapy. 2014, 15, 119-127. 

  11. J. Su, Y. Qiu, S. Jiang*, D. Zhang*. New Ligands for Copper-Catalyzed C-N Coupling Reactions at Gentle Temperature. Chinese Journal of Chemistry. 2014, 32(8), 685-688.

  12. J. Su, Y. Qiu, K. Ma, Y. Yao, Z. Wang, X. Li, D. Zhang, Z. Tu, S. Jiang*. Design, synthesis, and biological evaluation of largazole derivatives: alteration of the zinc-binding domain. Tetrahedron.2014, 70, 7763-7769.

  13. H. Zhou, S. Jiang, J. Chen, X. Ren, J. Jin, S. B. Su*. Largazole, an inhibitor of class I histone deacetylases, attenuates inflammatory corneal neovascularization. European Journal of Pharmacology.2014, 740, 619-626.

  14. H. Zhou, S. Jiang, J. Chen, S. B. Su*. Suberoylanilide hydroxamic acid suppresses inflammation-induced neovascularization. Can. J. Physiol. Pharmacol.2014, 92, 879-885.

  15. Y. Liu, Y. Liu, Z. Liu, G. Zhou, Z.-J. Yao*, S. Jiang*. Identification of novel bivalent mimetics of annonaceous acetogenins via a scaffold-hopping strategy. Bioorg. Med. Chem. Lett. 2014, 24, 1650-1653.

  16. Y. Liu, Q. Xiao, Y. Liu, Z. Li, Y. Qiu, G.-B. Zhou, Z.-J. Yao, S. Jiang*. Biological evaluation of new mimetics of annonaceous acetogenins: alteration of right scaffold by click linkage with aromatic functionalities. Eur. J. Med. Chem. 2014, 78, 248-258.

  17. Y. Yao, C. Liao, Z. Li, Z. Wang, Q. Sun, C. Liu, Z. Tu*, S. Jiang*. Design, Synthesis, and Biological Evaluation of 1, 3-Disubstituted-Pyrazole Derivatives as New Class I and IIb Histone Deacetylase Inhibitors. Eur. J. Med. Chem.  2014, 86, 639-652.

  18. Y. Zhao, X. Fang, Y. Wang, J. Zhang, S. Jiang, Z. Liu, Z. Ma, L. Xu, E. Li, K. Zhang. Comprehensive Analysis for Histone Acetylation of Human Colon Cancer Cells Treated with a novel HDAC Inhibitor. Current Pharmaceutical Design. 2014, 20, 1866-1873.

  19. D. Zou, Y. Qiu, Z. Tu, C. Liao, J. Luo, Q. Meng, R. Yao, Z. Li, S. Jiang*.. Biological evaluation of 2-methylpyrimidine derivatives as active pan Bcr-Abl inhibitors. Science China: Chemistry. 2014, 57, 823-832.

  20. Q. Meng, F. Li, S. Jiang, Z. Li*. Novel 64Cu-labeled CUDC-101 for in vivo PET Imaging of histone deacetylases. ACS Medicinal Chemistry Letters. 2013, 4, 858-862.

  21. L. Wu, Z. Wen, Y. Qiu, X. Chen, H. Chen, M. Wei, Z. Liu, S. Jiang*, G. Zhou*. Largazole arrests cell cycle at G1 phase and triggers proteasomal degradation of E2F1 in lung cancer cells; ACS Medicinal Chemistry Letters. 2013, 4, 921-926.

  22. Y. Yao, H. Yao, S. Jiang*, X. Xue*. Progress in clinical study of histone deacetylase inhibitors as anticancer agents; Chinese J New Drugs. 2013, 22 (3), 1-7.

  23. Q. Sun , Y. Yao,  C. Liu, H. Li, H. Yao, X. Xue, J. Liu, Z. Tu*, S. Jiang*. Design, Synthesis, and Biological Evaluation of Novel Histone Deacetylase 1 Inhibitors through click chemistry. Bioorg. Med. Chem. Lett. 2013, 23, 3295-3299.

  24. X. Li, Z. Tu, H. Li, C. Liu, Z. Li, Q. Sun, Y. Yao, J. Liu, S. Jiang*. Biological evaluation of new largazole analogues: Alteration of macrocyclic scaffold with Click chemistry; ACS Medicinal Chemistry Letters. 2013, 4, 132-136.

  25. Y. Qiu, W. Jia, Z. Yao, F. Wu, S. Jiang*. 2-Carbomethoxy-3-hydroxyquinoxaline-di-N-oxide as a novel ligand for the copper-catalyzed coupling reaction of phenols and aryl halides. Organic & Biomolecular Chemistry. 2013, 11, 1502-1510.

  26. Yang, Mei; He, Jiangbo; Cheng, Yongxian; S. Jiang*. Synthesis of 3-[(Z)-pentadec-8-enyl]catechol and its anti-angiogenesis activity. Chinese Journal of Organic Chemistry. 2013, 33(6), 1319-1325.

  27. D. Che, K. Yang, H. Xiang, S. Jiang*. New ligands for copper-catalyzed C-N coupling reactions with aryl halides; Tetrahedron Letters. 2012, 53, 7121-7124.

  28. Y. Liu, X. Cheng, L. Guo, C. Mao, Y. Chen, H. Liu, Q. Xiao, S. Jiang, Z. Yao, G. Zhou. Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells; PLoS One. 2012, 7, e47049.

  29. K. Su, Y. Qiu,; Y. Yao,; D. Zhang, S. Jiang*. 8-hydroxyquinolin-N-oxide-promoted copper-catalyzed C-S cross-coupling of thiols with aryl iodides; Synlett. 2012, 23, 2853-2857.

  30. Q. Xiao, Y. Liu, Y. Qiu, G. Zhou, C. Mao, Z. Li, Z.-J. Yao*, S. Jiang*. Potent Antitumor Mimetics of Annonaceous Acetogenins Embedded with an Aromatic Moiety in the Left Hydrocarbon Chain Part; J. Med. Chem.2011, 54, 525-533.

  31. K. Yang, Y. Qiu, Z. Li, Z. Wang, S. Jiang*, Ligands for Copper-Catalyzed C- N Bond Forming Reactions with 1 Mol% CuBr as Catalyst. J. Org. Chem, 2011, 76, 3151-3159.

  32. Y. Qiu, Y. Liu, K. Yang, W. Hong, Z. Li, Z. Wang, S. Jiang*. New Ligands That Promote Cross-Coupling Reactions between Aryl Halides and Unactivated Arenes. Org. Letters, 2011, 13, 3556-3559.

  33. K. Yang, Z. Li, Z. Wang, S. Jiang*. Highly Efficient Synthesis of Phenols by Copper-Catalyzed Hydroxylation of Aryl Iodides, Bromides, and Chlorides. Org. Letters, 2011, 13, 4340-4343.

  34. W. Wu, Z. Li, G. Zhou, S. Jiang*. Total synthesis of argyrins A and E. Tetrahedron. Lett. 2011, 52, 2488-2491.

  35. Z. Yao, X. Zeng, W. Yi, S. Jiang*. Stereoselective Synthesis of (S,E)-2-(trimethylsilyl)ethyl 3-hydroxy-7-(tritylthio) hept-4-enoate. Letters in Organic Chemistry, 2011, 8, 66-69.

  36. Q. Xiao, Y. Liu, Y. Qiu, Z. Yao, G. Zhou, Z.-J. Yao*, S. Jiang*. Design, synthesis of symmetrical bivalent mimetics of annonaceous acetogenins and their cytotoxicities. Bioorg. Med. Chem. Lett. 2011, 21, 3613-3615.

  37. S. Li, H. Yao, J. Xu*, S. Jiang*. Synthetic Routes and Biological Evaluation of Largazole and Its Analogues as Potent Histone Deacetylase Inhibitors. Molecules, 2011, 16, 4681-4694.

  38. L. Johannessen, J. Remsberg, V. Gaponenko, K. M. Adams, J. J. Barchi, S. G. Tarasov, S. Jiang,  N. I. Tarasova. Peptide Structure Stabilization by Membrane Anchoring and its General Applicability to the Development of Potent Cell-Permeable Inhibitors. ChemBioChem.2011, 12, 914-921.

  39. Z. Yao, Y. Xu, M. Zhang, S. Jiang, M. C. Nicklaus, C. Liao. Discovery of a novel hybrid from finasteride and epristeride as 5a-reductase inhibitor. Bioorg. Med. Chem. Lett,2011, 21, 475-478.

  40. W. Hong, Y. Qiu, Z. Yao, Z. Wang, S. Jiang*. Palladium-Catalyzed Direct C–H Arylation of Unactivated Arenes with Aryl Halides. Tetrahedron. Lett. 2011, 52, 4916-4919.

  41. X. Zeng, W. Huang, Y. Qiu, S. Jiang*. Efficient Copper-Catalyzed Synthesis of Anilines by Employing Aqueous Ammonia. Organic & Biomolecular Chemistry. 2011, 9, 8224-8227.

  42. Y. Xu, F. Wu, Z. Yao, S. Jiang. Synthesis of quinoxaline 1,4-di-N-oxide analogues and crystal structure of 2-carbomethoxy-3-hydroxyquinoxaline-di-N-oxide. Molecules, 2011, 6894-6901.

  43. X. Zeng, B. Yin, Z. Hu, C. Liao, Z. Li, G. Zhou*, S. Jiang*.Total Synthesis and Biological Evaluation of Largazole and Derivatives with Promising Selectivity for Cancers Cells. Orgainc. Lett. 2010, 12, 1368-1371.

  44. J. Zheng, B. Yin, W. Huang, X. Li, H. Yao, Z. Liu, S. Jiang*. Efficient and selective cleavage of the t-butoxycarbonyl group from di-t-butylimidodicarbonate using catalytic bismuth (III) bromide in acetonitrile. Tetrahedron. Lett. 2009, 50, 5094-5097.

  45. S. Jiang*, C. Liao, L. Bindu, B. Yin, K. W. Worthy, R. J. Fisher, T. R. Burke, Jr., M. C. Nicklaus, P. P. Roller. Discovery of thioether-bridged cyclic pentapeptides binding to Grb2-SH2 domain with high affinity. Bioorg. Med. Chem. Lett.2009, 19, 2693-2698.

  46. Z. Nikolovska-Coleska, J. Meagher, S. Jiang, C. Yang, S. Qiu, P. P. Roller, J. Stuckey, S. Wang. Interaction of a Cyclic, Bivalent Smac Mimetic with the X-Linked Inhibitor of Apoptosis Protein. Biochemistry. 2008, 47, 9811-9824.

  47. S. Jiang*, Z. Li, K. Ding, P. P. Roller. Recent Progress of Synthetic Studies to Peptide and Peptidomimetic Cyclization. Current Organic Chemistry.2008, 12, 1502-1542.

  48. Z. Nikolovska-Coleska, J. Meagher, S. Jiang, S. A. Kawamoto, W. Gao, H. Yi, D. Qin, P. P. Roller, J. Stuckey, S. Wang. Design and characterization of bivalent Smac-based peptides as antagonists of XIAP and development and validation of a fluorescence polarization assay for XIAP containing both BIR2 and BIR3 domains. Anal Biochem. 2008, 374, 87-98.

  49. O. A. Timofeeva, V. Gaponenko, S. J. Lockett, S. G. Tarasov, S. Jiang, C. J. Michejda, A. O. Perantoni, N. I. Tarasova. Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. ACS Chem Biol.2007, 2, 799-809.

  50. S. Jiang, P. Li, S. L. Lee, C. Y. Lin, Y.Q Long, M. D. Johnson, R. B. Dickson, P. P. Roller. Design and Synthesis of redox stable analogues of Sunflower Trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of Matriptase. Orgainc.Lett. 2007, 9, 9-12.

  51. H-X. Liu, G-R. Huang, H-M Zhang, S. Jiang, J.-R. Wu, Z. -J. Yao. A Structure-Activity Guided Strategy for Fluorescent Labeling of Annonaceous Acetogenin Mimetics and their Application in Cell Biology. ChemBioChem.2007, 8, 172-177.

  52. P. Li, S. Jiang, S. L. Lee, C. Y. Lin, M. D. Johnson, C. J. Michejda, R. B. Dickson, P. P. Roller. Synthesis and evaluation of analogs of SFTI-1, potent inhibitors of the Type II transmembrane serine protease, Matriptase. J. Med. Chem. 2007, 50, 5976-5983.

  53. P. Li, S. Jiang, P. C. Stephanie, O. Lyn, D. N. Krag, P. P. Roller. Design and Synthesis of Water-Soluble Conjugates of Paclitaxel to Extracellular Doma in of ErbB2-Recognizing Peptide. Biopolymers. 2007, 87, 225-230.

  54. H. Sun, Z. Nikolovska-Coleska, J. Lu, J. Meagher, C. Yang, S. Qiu, Y. Tomita, Y. Ueda, S. Jiang, Krajewski, P. P. Roller, J. A. Stuckey, S. Wang. Design, Synthesis and Characterization of A Potent, Non-Peptide, Cell-Permeable, Bivalent Smac Mimetic that Concurrently Targets both the BIR2 and BIR3 Domains in XIAP. J. Am. Chem. Soc.  2007, 129, 15279-15294.

  55. G. Z. Tang, C. Y. Yang, Z. Nikolovska-Coleska, J. Guo, S. Qiu, R. X. Wang, W. Gao, G. P. Wang, J. Stuckey, K. Krajewski, S. Jiang, P. P. Roller, S. Wang. Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins. J. Med. Chem.2007, 50, 1723-1726.

  56. G. Z. Tang, K. Ding, Z. Nikolovska-Coleska, C. Y. Yang, S. Qiu, S. Shangary, R. X. Wang, J. Guo, W. Gao, J. Meaghe, J. Stuckey, K. Krajewski, S. Jiang, P. P. Roller, S. Wang. Structure-Based Design of Flavonoid Compounds As a New Class of Small-Molecule Inhibitors of the Anti-apoptotic Bcl-2 Proteins. J. Med. Chem.2007, 50, 3163-3166.

  57. J. Chen, Z. Nikolovska-Coleska, C. Y. Yang, C. Gomez, W. Gao, K. Krajewski, S. Jiang, P.  P. Roller, S. Wang. Design and synthesis of a new, conformationally constrained, macrocyclic small-molecule inhibitor of STAT3 via ‘click chemistry’. Bioorg. Med. Chem. Lett.2007, 17, 3939-3942.

  58. S. Jiang, P. Li, C. C. Lai, J.A. Kelley, P. Roller. Design and Practical Synthesis of Fully Protected analogs of L-γ-Carboxyglutamic Acid. J. Org. Chem.2006, 71, 7307-7314.

  59. S. Jiang, P. Li, M. Peach, R. J. Fisher, T. R. Burke, M. Nicklaus, P. P. Roller. Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics. Biochem. Biophys. Res. Commun.2006, 349, 497-503.

  60. S. Jiang, C. C. Lai, J. A. Kelley, P. P. Roller. A  Practical Synthesis of Fully Protected L-γ-Carboxyglutamic Acid (L-Gla). Tetrahedron. Lett. 2006, 47, 23-25.

  61. G. P. Wang, Z. Nikolovska-Coleska, C. Y. Yang, R. X. Wang, G. Z. Tang, J. Guo, S.   Shanggary, S. Qiu, W. Gao, D. J. Yang, J. Meagher, J. Stuckey, K. Krajewski, S. Jiang, P. P. Roller, H.O. Abbaan, Y. Tomita, S. Wang. Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J. Med. Chem.2006, 49, 6139-6142.

  62. Y. Zhao, S. Jiang, Y. W. Guo, Z.-J. Yao. Synthesis of two naturally occurring 4-hydroxylated butenolides with PTP1B inhibitory activity. Chinese. J. Chem. 2005, 23, 173-175.

  63. S. Jiang, Y. Li, X. G. Chen, T. S. Hu, Y. L. Wu, Z.-J. Yao. Parallel fragment assembly strategy towards multiple-ether mimicry of anticancer annonaceous acetogenins. Angew. Chem. Int. Ed.  2004, 43, 329-334.

  64. G. R. Huang, S. Jiang, Y. L. Wu, Z. J. Yao, J.R. Wu. Induction of cell death of gastric cancer cells by a modified compound of the annonaceous acetogenin family. Chem BioChem2003, 4, 1216-1221.

  65. B.B. Zeng, Y.K. Wu, S. Jiang, Q. Yu, Z.J. Yao, Z. Liu, H. Li, Y. Li, X. Chen, Y.L. Wu. Studies on Mimicry of Naturally occuring Annonaceous Acetogenins: Non-THF Analogues Leading to Remarkable Selective Cytotoxicity Against Human Tumor cells. Chem. Eur. J.2003, 9, 282-290.

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