Dr. Zhou has been working as a teacher and researcher in the Medicinal Chemistry Department since 1999 after graduation with Ph. D. In 2001, Zhou became deputy researcher, and professor in 2010. Dr. Zhou was rewarded Servier Award of Medicinal Chemistry in 2000. China pharmacy pharmaceutical chemistry (Servier). Dr. Zhou worked as a visiting scholar in Gifu Pharmaceutical University, Japan from 2005 to 2006 .
Research direction: new drug for cancer and cardiovascular diseases treatment. Research Topics: responsible for the completion of a 863 doctoral project funded by the Ministry of Science and Tchnology; Nanjing Municipal Foundation for Return Researcher. Participated in the National Natural Science Foundation, the national endowment for the new drug, "863" project, the medical bureau control project and so on . In these foundation research projects including Natural Science Fund, New Drugs Fundations, of, and Jiangsu Province Natural Science Fundations, based on the structure-activity relationship of the tumor, infection and inflammation disease, diabetes and other diseases complicated pathogenesis and drug, Dr. Zhou has benn studying on molecular design and synthesis of novel drugs, which has been endowed with independent intellectual property rights. Dr. Zhou has worked as experts and the reviewer of a number of funds for domestic and foreign funds, SCI Journal papers. Dr. Zhou has applied for 14 patents, published more than 50 articles.
Email: jpzhou668@163.com Tel 13951694488
1. Yifei Yang, Leilei Zhao, Bin Xu, LingYun Yang, Jian Zhang, Huibin Zhang, Jinpei Zhou*. Design, synthesis and biological evaluation of dihydroquinoxalinone derivatives as BRD4 inhibitors. Bioorganic Chemistry 68 (2016) 236–244.
2. Yifei Yang, Fangxia Zou, Leilei Zhao, Yulan Cheng, Xiaoming Zha, Huibin Zhang, Jinpei Zhou*. Combined pharmacophore models as virtual screening protocol against BRD4(1) inhibitor. Med Chem Res (2016) 25:585–595.
3. Bin Xu, Lei-Lei Zhao, Yi-Fei Yang, Jian Zhang, Ling-Yun Yang, Bing Zhang, Li Han, Hui-Bin Zhang*, and Jin-Pei Zhou*. Synthesis and Biological Activity of Quinoxalone Derivatives as BRD4 Bromodomain Inhibitors. Letters in Drug Design & Discovery, 2016, 13, 1-8
4. Lingyun Yang, Li Han, Bin Xu, Leilei Zhao, Jinpei Zhou, and Huibin Zhang*. Palladium-Catalyzed C−H Bond Ortho Acylation/Annulation with Toluene Derivatives Toluene Derivatives. Asian Journal of Organic Chemistry, 2016, 5 (1), 62-65
5. Qing Li, Li Han, Bin Zhang, Jinpei Zhou and Huibin Zhang*. Synthesis and biological evaluation of triazole based uracil derivatives as novel DPP-4 inhibitors. Organic & Biomolecular Chemistry, 2016, 14, 9598-9611
6. Lingyun Yang, Jian Zhang, Lianghui Si, Li Han, Bo Zhang, Hui Ma, Junhao Xing,Leilei Zhao, Jinpei Zhou, Huibin Zhang*. Synthesis and Biological Evaluation of GPR40/FFAR1 Agonists Containing 3,5-dimethylisoxazole. European Journal of Medicinal Chemistry, 2016, 116, 46-58 IF 3.902
7. Xueting Cai, Jie Yang , Jinpei Zhou, Wuguang Lu, Chunping Hua, Zhenhua Gu, Jiege Huo ,Xiaoning Wang, Peng Cao. Synthesis and biological evaluation of scopoletin derivatives. Bioorganic & Medicinal Chemistry, 21 (2013), 84-92.
8. Xiong Zhu, Jinpei Zhou*,, Yan Zhu, Xiaowen Hu, Yuemin Bian, Xinting Hu, Zhuo Tao, Cong Gao and Wenlong Huang. Synthesis and Biological Activities of Sulfinyl Acetamide Derivatives for Narcolepsy Treatment.Letters in Drug Design & Discovery, 2013, 10, 266-270
9. Wukun Liu, Jie Hua, Jinpei Zhou*, Huibin Zhang, Haiyang Zhu, Yanhua Cheng, Ronald Gust. Synthesis and in vitro antitumor activity of novel scopoletin derivatives. Bioorganic & Medicinal Chemistry Letters, 22 (2012), 5008-5012
10. Wukun Liu, Jinpei Zhou*, Tong Zhang, Huibin Zhang, Haiyang Zhu, Yanhua Cheng, Ronald Gust. Synthesis and biological evaluation of cyanoguanidine derivatives of loratadine. Bioorganic & Medicinal Chemistry Letters, 22 (2012), 6076-6080.
Jinpei Zhou, Lei Wang, Lijuan Wei, Yu Zheng, Huibin Zhang , Yubin Wang, Peng Cao, Ao Niu, Jing Wang and Yue Dai. Synthesis and Antitumor Activity of Scopoletin Derivatives. Letters in Drug Design & Discovery, 2012, 9(4), 397-401
Wukun Liu, Jinpei Zhou*, Tong Zhang, Haiyang Zhu, Hai Qian, Huibin Zhang, Wenlong Huang,Ronald Gust. Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters, 2012, 22: 2701-2704
Wukun Liu, Jinpei Zhou#, Yu Zheng, Fan Qi, Huibin Zhang, Hai Qian, Jing Wang1,Yanhua Cheng and Ronald Gust. Design, Synthesis and Antiproliferative Activity of 2-Acetamidothiazole-5-carboxamide Derivatives. Medicinal Chemistry, 2012, 8, 587-594
Wukun Liu, Jinpei Zhou*, Fan Qi, Kerstin Bensdorf, Zhiyu Li, Huibin Zhang, Hai Qian,Wenlong Huang, Xueting Cai, Peng Cao, Anja Wellner, and Ronald Gust. Synthesis and Biological Activities of 2-Amino-thiazole-5-carboxylic Acid Phenylamide Derivatives. Arch. Pharm. Chem. Life Sci. 2011, 344, 451–458 451
Wukun Liu, Jinpei Zhou*, Kerstin Bensdorf , Huibin Zhang, Haoran Liu, YubinWang , Hai Qian,Yanchun Zhang, Anja Wellner, Gerhard Rubner, Wenlong Huang, Cancheng Guo, Ronald Gust. Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives. European Journal of Medicinal Chemistry, 2011, 46, 907-913
Wukun Liu, Jinpei Zhou*, Huibin Zhang, Hai Qian, Jiahan Yin, Kerstin Bensdorf and Ronald Gust. Synthesis and Biological Evaluation of Licofelone Derivatives as Anticancer and Anti-inflammatory Agents. Letters in Drug Design & Discovery, 2011, 8, 911-917
Jinpei Zhou, Hai Qian, Huibin Zhang, Hui Gao, Wenlong Huang, Xiaoyun Zhu, Shuaijian Ni, and Chuntao Zhang. Design, Synthesis and Biological Evaluation of Benzopyran Derivatives as KATP Channel Openers. Letters in Drug Design & Discovery, 2010, 7(6), 415-420
Jinpei Zhou, Shuaijian Ni, Huibin Zhang, Hai Qian, Yushi Chi, Wenlong Huang, Lu Yu, Xiaowen Hu and Wei Chen. Synthesis and Bioactivity Evaluation of Dipeptidyl Peptidase IV Resistant Glucagon-like Peptide-1 Analogues. Protein and Peptide Letter, 2010, 17(10), 1290-1295
Hai Qian, Wei Chen, Xiaoyan Zhang, Huibin Zhang, Jinpei Zhou*, Wenlong Huang, Jing Jin and Dongyan Dai.Synthesis and Biological Evaluation of Dihydroisoquinoline-2(1H)-Carbothioamide Derivatives as TRPV1 Antagonists. Letters in Drug Design & Discovery, 2010, 7(4): 235-237
Yanchun Zhang, Jinpei Zhou*, Weihong Pan, Xiaoming Wu, and Shuai Wang. Synthesis and Biological Study of 3-Butyl-1-(2,6-dichlorophenyl)-1H-[1,2,4]triazol-5(4H)-one Derivatives as Anti-hypertension Drugs. Letters in Drug Design & Discovery, 2010, 7(1): 18-22
Hai Qian, Wei Chen, Jin Pei Zhou*, Wen Long Huang, Hui Bin Zhang, Jing Jin. Total Synthesis of endothelin 1 by microwave-assisted solid phase method. Chinese Chemical Letters, 2010, 21:388-390
Hai Qian, Zhixian Fu, Huibin Zhang, Jinpei Zhou*, Wenlong Huang, Jing Jin, Wei Chen and Dongyan Dai. Synthesis and Biological Evaluation of Capsaicin Derivatives as Analgesia Drugs. Letters in Drug Design & Discovery, 2010, 7(2), 122-127
Jinpei Zhou, Xiaowen Hu, Huibin Zhang, Hai Qian, Wenlong Huang, Fan Qi and Yanchun Zhang. Synthesis and Biological Evaluation of 5,6-Dihydro-benzo[c] acridin-7-ol Derivatives as Anti-Alzheimer’s Disease Drugs. Letters in Drug Design & Discovery, 2009，6(8): 623-628
Jinpei Zhou, Huibin Zhang, Hai Qian, Liang Lin, Wenlong Huang and Shuaijian Ni. Synthesis and Biological Evaluation of Aromatase Inhibitors. Letters in Drug Design & Discovery, 2009，6(3): 181-185
ZHANG Hui-bin, ZHANG Ya-an, WU Guan-zhong, ZHOU Jin-pei*. HUANG Wen-long, HU Xiao-wen. Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents. Bioorganic & Medicinal Chemistry Letters, 2009，19（6）：1740-1744
Xiangyang Sha, Huibin Zhang, Wenlong Huang, Jinpei Zhou*, Yinghong Zhou. Design and Synthesis of Thiazolidinedione Derivatives as Selective PPARγ Modulators. Letters in Drug Design & Discovery, 2009，6(3): 224-227
